Pranav Narayanan
A5069186531- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Plant Pathogenic Bacteria Studies
- Acute Myeloid Leukemia Research
- Cancer Research and Treatments
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
The University of Texas MD Anderson Cancer Center
2025
Rice University
2025
University of Michigan
2023
The mutational landscape of phylogenetically ultraconserved elements (UCEs), especially those in noncoding DNAs (ncUCEs), and their functional relevance cancers remain poorly characterized. Here, we perform a systematic analysis whole-genome in-house targeted UCE sequencing datasets from more than 3000 patients with cancer 13,736 UCEs demonstrate that ncUCE somatic alterations are common. Using multiplexed CRISPR knockout screen colorectal cells, show the loss several altered ncUCEs...
Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by cytopenia and extramedullary hematopoiesis, resulting in splenomegaly. Multiple pathological mechanisms (e.g., circulating cytokines genetic alterations, such as JAKV617F mutation) have been implicated the etiology of MF, but molecular mechanism causing resistance to JAK2V617F inhibitor therapy remains unknown. Among MF patients who were treated with JAK ruxolitinib, we compared noncoding RNA profiles ruxolitinib responders...
Abstract Ependymomas are fatal brain malignancies with very few treatment options. More than 70% of supratentorial (ST) ependymomas harbor fusions the zinc-finger containing, chromatin modifier ZFTA and transcriptional activator NF-κB signaling, RELA. Oncogene-driven metabolic reprogramming is a fundamental hallmark cancer that enables sustained tumor proliferation. ZFTA-RELA fusion protein essential for tumorigenesis our goal to determine how it drives metabolism in ST-ependymomas. To...