A5100649695- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Nutrition and Health in Aging
- Bladder and Urothelial Cancer Treatments
- Frailty in Older Adults
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Treatments and Mutations
- Urinary and Genital Oncology Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Esophageal Cancer Research and Treatment
- Diet, Metabolism, and Disease
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Diet and metabolism studies
- Renal and related cancers
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Exercise and Physiological Responses
- Cancer, Hypoxia, and Metabolism
- Body Contouring and Surgery
- Neuroendocrine Tumor Research Advances
Catholic University of Korea
2016-2025
Seoul St. Mary's Hospital
2016-2025
Seoul National University Hospital
2023
Samsung Medical Center
2022
Sungkyunkwan University
2022
Korea Food Research Institute
2004
Abstract Genomic profiling can provide prognostic and predictive information to guide clinical care. Biomarkers that reliably predict patient response chemotherapy immune checkpoint inhibition in gastric cancer are lacking. In this retrospective analysis, we use our machine learning algorithm NTriPath identify a gastric-cancer specific 32-gene signature. Using unsupervised clustering on expression levels of these 32 genes tumors from 567 patients, four molecular subtypes for survival. We...
This study aimed to assess the effect of antibiotics on clinical outcomes patients with solid cancers undergoing treatment immune checkpoint inhibitors (ICIs).The medical records 234 treated ICIs for any type cancer between February 2012 and May 2018 at Seoul St. Mary's Hospital were retrospectively reviewed. The data who received within 60 days before initiation ICI analyzed. patients' responses their survival evaluated.Non-small-cell lung carcinoma was most common cancer. About half...
Abstract Background To investigate the clinical impact of sarcopenia and skeletal muscle density (SMD) among patients with metastatic pancreatic adenocarcinoma who underwent palliative first line gemcitabine-based chemotherapy. Methods A total 330 treated chemotherapy between January 2010 March 2017 were included. CT scans before after 8±2 weeks evaluated. The L3 index (SMI) was used to detect calculated as area divided by height-squared (cm2/m2). SMD quantified mean radiation attenuation...
4010 Background: Bema is a first-in-class humanized IgG1 monoclonal antibody selective for fibroblast growth factor receptor 2b (FGFR2b). Results from the FIGHT study showed an improvement in progression-free survival (PFS), overall (OS), and response rate with addition of bema to mFOLFOX6 FGFR2b+, non HER2+ GC. This report provides updated analyses patient (pt) subgroups, additional data on ocular adverse events (AEs), median OS result bema+mFOLFOX6 combination. Methods: Pts were treated...
Abstract Background In the FIGHT study (NCT03694522) bemarituzumab, a humanized monoclonal antibody selective for fibroblast growth factor receptor 2b (FGFR2b), plus mFOLFOX6 showed clinically meaningful efficacy in patients with FGFR2b-positive (2+/3+ membranous staining by immunohistochemistry) locally advanced unresectable/metastatic gastric/gastroesophageal cancer (G/GEJC). A proportion of were enrolled East Asia, reflecting global epidemiology G/GEJC. Methods This subgroup analysis...
Claudin-18.2 (CLDN18.2) is specifically expressed in pancreatic precancerous lesions and ductal adenocarcinoma (PDAC). We assessed the clinical characteristics of patients with CLDN18.2-overexpressing cancer to identify who might benefit from CLDN18-targeted treatment. A total 130 surgically resected PDAC were investigated for immunohistochemical expression claudin-18 (CLDN18). The CLDN18 staining intensities (0–3+) relative proportion positive tumor cells analyzed by two independent raters....
Muscle atrophy, a physiological decline in muscle mass and strength due ageing, occurs through an imbalance between protein breakdown synthesis. The purpose of this study was to verify whether amino acid complex supplementation (ACS) can prevent treat loss dexamethasone (Dexa, 800 μg/kg)-induced rat model sarcopenia. Sprague Dawley rats (6 weeks old) were assigned seven groups: (i) normal control, (ii) positive control (high-dose ACS, 500 mg), (iii) Dexa only, (iv) + high-dose ACS (500 (v)...
Objective Hyperthermia has been safely employed in conjunction with low to moderate doses of radiotherapy (RT) achieve notable tumor responses cases previously treated and recurrent malignancies. However, the radiologic monitoring combined hyperthermia RT (HTRT) is not extensively documented. This study aimed assess radiological changes, including alterations Hounsfield units (HU), patients undergoing treatment either HTRT or alone for metastatic abdominal lymph nodes. Methods CT images were...
Introduction: The Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) is widely used to assess patient status but relies on subjective judgment and may not fully reflect their physical reserve. While studies have shown that skeletal muscle quality quantity are associated with prognosis, role in cancers of unknown primary (CUP) remains unclear. Therefore, this study aimed investigate whether computed tomography (CT)-based indicators reserve prognostic value patients CUP....
4067 Background: The phase 3 PRODIGY study compared neoadjuvant docetaxel, oxaliplatin and S-1 (DOS) chemotherapy followed by surgery adjuvant with for Korean patients resectable locally advanced gastric cancer (LAGC) (Kang et al. J Clin Oncol. 2021). planned analysis of the primary endpoint showed that addition DOS to improved progression-free survival (PFS). We herein report long-term follow-up outcomes, including overall (OS), from this trial. Methods: Patients histologically confirmed or...
Abstract Background The clinical significance of pre-sarcopenia in colorectal cancer obstruction has not yet been described. present study aimed to determine the short- and long-term oncologic impacts obstructive cancer. Methods We retrospectively analyzed 214 patients with colon between January 2004 December 2013. Initial staging computed tomography (CT) scans identified visceral obesity by measuring muscle fat areas at third lumbar vertebra level. Both short-term postoperative outcomes...
Gastric cancer is the fourth most common worldwide and more frequently detected in Asian countries including Korea Japan. The incidence of young-age gastric (GC) increasing worldwide, but clinical behavior GC patients not well established. We retrospectively analyzed features outcomes diagnosed at population.Between Jan. 2009 to 2015, 163 as early, advanced, recurrent, or metastatic ages between 22 ~ 39 years were analyzed. Based on medical records, authors clinicopathologic characteristics...
Next-generation sequencing (NGS) is becoming essential in the fields of precision oncology. With implementation NGS daily clinic, needs for continued education, facilitated interpretation results and optimal treatment delivery based on have been addressed. Molecular tumor board (MTB) multidisciplinary approach to keep pace with growing knowledge complex molecular alterations patients advanced solid cancer. Although guidelines use MTB developed western countries, there limitation reflection...
292 Background: Despite recent approval of anti-PD-1 antibodies as 1L therapy in HER2(-) advanced GEA, benefit remains modest and limited largely to PD-L1(+) patients (pts), primarily those with combined positive scores (CPS) ≥5. Thus novel therapeutic approaches are needed for this pt population. DKN-01 is a targeted anti-DKK1 mAb which has demonstrated improved clinical outcomes pts elevated tumoral DKK1 expression, subset more aggressive disease shorter overall survival. Methods:...
The incidence of colorectal cancer (CRC) is increasing in young-age patients, but the clinical history not established. Authors analyzed characteristics onset CRC to support basic information for setting treatment policies. Between January 2006 2014, 100 patients diagnosed at age 10 39 were analyzed. clinicopathologic reviewed based on medical records. Survival outcomes including overall survival (OS), disease-free (DFS), and progression-free (PFS) This study was conducted as a...
Markers of inflammation have been associated with outcomes in various cancers. The purpose this study was to evaluate whether systemic inf lammatory markers and their f luctuations can predict survival chemotherapy response patients metastatic gastric cancer (mGC).We retrospectively reviewed the records 502 who received first-line palliative for mGC between 2007 2013. neutrophil-to-lymphocyte ratio (NLR) modified Glasgow prognostic score (mGPS) were assessed before after association...
TPS484 Background: Advanced G/GEJ cancer is a major cause of cancer-related mortality requiring novel therapies. DKN-01 humanized mAb that binds and neutralizes DKK1. DKK1 plays role in WNT-pathway regulation overexpressed multiple cancers. expression associated with poor prognosis, an immunosuppressive tumor microenvironment, resistance to chemotherapy cancer. The non-randomized Part A DisTinGuish demonstrated durable clinical benefit patients adenocarcinoma. Higher response rates were...
Because the unanticipated arousal or hemodynamic instability during anesthesia may adversely affect physical and emotional welfare of children, adequate management depth is required. We aimed to compare Bispectral Index (BIS) Patient State (PSI) in children sevoflurane evaluate PSI as monitor aged 6 months-12 years.In this prospective observational study, years old scheduled for elective surgery under were enrolled from November 2018 June 2019. monitored BIS at different concentrations. The...