A5100781068- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Renal and related cancers
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Genetic and Kidney Cyst Diseases
- Cancer Mechanisms and Therapy
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Urological Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Ferroptosis and cancer prognosis
- Neuroblastoma Research and Treatments
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Monoclonal and Polyclonal Antibodies Research
- DNA Repair Mechanisms
- Glycosylation and Glycoproteins Research
- Lung Cancer Research Studies
- MRI in cancer diagnosis
- Sirtuins and Resveratrol in Medicine
Catholic University of Korea
2023-2025
Seoul St. Mary's Hospital
2023-2025
Konkuk University Medical Center
2022-2024
Dongwha Pharm (South Korea)
2024
Samsung Medical Center
1998-2023
The Ohio State University
2023
Keimyung University
2023
Indiana University School of Medicine
2022
Sungkyunkwan University
1998-2022
Seoul National University Hospital
2022
There are no proven, effective therapies for polycystic kidney disease (PKD) or liver (PLD). We enrolled 42 patients with severe PLD resulting from autosomal dominant PKD (ADPKD) (ADPLD) in a randomized, double-blind, placebo-controlled trial of octreotide, long-acting somatostatin analogue. randomly assigned 2:1 ratio to octreotide LAR depot (up 40 mg every 28+/-5 days) placebo 1 year. The primary end point was percent change volume baseline year, measured by MRI. Secondary points were...
High-b-Value Diffusion-Weighted Imaging at 3 T to Detect Prostate Cancer: Comparisons Between b Values of 1,000 and 2,000 s/mm2Chan Kyo Kim1, Byung Kwan Park1 Bohyun Kim2Audio Available | Share
We showed in a randomized double-blinded placebo-controlled clinical trial that octreotide long-acting repeatable depot.® (OctLAR®) for 12 months reduces kidney and liver growth autosomal dominant polycystic patients with severe disease (PLD) isolated PLD. have now completed an open-label extension one additional year to assess safety benefits of continued use OctLAR 2 years (O→O) examined drug effect the placebo group who crossed over Year (P→O). The primary end point was change total...
Abstract The prognostic role of soluble PD-L1 (sPD-L1) and exosomal (exoPD-L1) in patients with gastric cancer (GC) receiving systemic chemotherapy remains unelucidated. Thus, we examined their significance advanced GC. Blood samples were obtained from 99 GC first-line chemotherapy. Serum-derived exosomes isolated by centrifugation polymer precipitation. correlation between serum-derived exoPD-L1, plasma sPD-L1, immune-related markers, circulating immune cells was evaluated. Patients divided...
Metabolic dysregulation is an important hallmark of cancer. Nicotinamide (NAM), a water‐soluble amide form niacin (vitamin B3), currently available as supplement for maintaining general physiologic functions. NAM crucial regulator mitochondrial metabolism and redox reactions. In this study, we aimed to identify the mechanistic link between NAM‐induced metabolic regulation therapeutic efficacy in triple‐negative breast cancer (TNBC). The combined analysis using multiomics systems biology...
Objective Hyperthermia has been safely employed in conjunction with low to moderate doses of radiotherapy (RT) achieve notable tumor responses cases previously treated and recurrent malignancies. However, the radiologic monitoring combined hyperthermia RT (HTRT) is not extensively documented. This study aimed assess radiological changes, including alterations Hounsfield units (HU), patients undergoing treatment either HTRT or alone for metastatic abdominal lymph nodes. Methods CT images were...
Muscle-invasive urothelial carcinoma (MIUC) of the bladder shows highly aggressive tumor behavior, which has prompted quest for robust biomarkers predicting invasion. To discover such biomarkers, we first employed high-throughput proteomic method and analyzed tissue biopsy cohorts from patients with (BUC), stratifying them according to their pT stage. Candidate were selected through bioinformatic analysis, followed by validation. The latter comprised 2D 3D invasion migration assays, also a...
Aims Immunohistochemical ( IHC ) staining for cytokeratin CK 5/6, CD 44 and 20 has been significantly associated with the prognosis of urinary bladder urothelial carcinoma, probably reflects its molecular characteristics. We aimed to investigate ‐based subgroups their prognostic effects on non‐muscle‐invasive papillary upper tract carcinoma UTUC ). Methods results was analysed in 211 patients . Staining classified as showing a negative, positive or normal pattern. found that 5/6‐negative,...
CD44 isoforms are highly expressed in cancer stem cells, initiating tumor growth and sustaining self-renewal. Among these isoforms, variant 9 (CD44v9) is overexpressed chronic inflammation-induced cancer. the mesenchymal-to-epithelial transition (MET) receptor tyrosine kinase coactivated some gastric cancers (GCs). In this study, we characterized MET expression signaling human GC cell lines analyzed differences susceptibility of to foretinib.We viability rate apoptotic cells using MTS assays...
Although urothelial papilloma (UP) is an indolent papillary neoplasm that can mimic the morphology of low-grade carcinoma (PUC), there no immunomarker to differentiate reliably these two entities. In addition, molecular characteristics UP are not fully understood.
Aim . HER2 overexpression has been reported in a minority of urothelial carcinomas, but little is known about protein expression and gene alterations plasmacytoid carcinoma, rare aggressive variant. The aim this study was to clarify the status carcinomas. Methods Six cases carcinoma were included, which we evaluated by immunohistochemistry (IHC) amplification fluorescence situ hybridization (FISH). Results patients’ ages ranged from 57 83 years (mean age, 71 years). Five patients male one...
Gastric cancer is more open related to genetic predisposition. In our RNA sequencing study on gastric patients, Runt-related transcription factor-3 (RUNX3) expression was significantly down-regulated in cancer. We showed that decreased levels of RUNX3 are associated with c-MET (r = − 0.4216, P 0.0130). addition, a candidate for targeted therapy Therefore, the present study, anti-cancer effects inhibitor cells from positive or negative amplification were evaluated. INC280 treatment inhibits...
Background Multidetector computed tomography (MDCT) is widely accepted as an effective imaging modality in monitoring for bladder cancer recurrence after radical cystectomy. Elucidating the pattern of on CT can increase diagnostic accuracy. Purpose To evaluate patterns transitional cell carcinoma and factors associated with recurrence. Material Methods One hundred forty-nine consecutive patients (mean age, 66.55 years; range, 32–86 years) who underwent preoperative contrast-enhanced...
Primary renal well-differentiated neuroendocrine tumors (WDNETs) also called carcinoid and atypical are extremely rare, little is known about parameters that may predict prognosis at diagnosis. Six cases of primary WDNET were collected. After reviewing slides stained with hematoxylin eosin, proportions each growth pattern determined. Synaptophysin, chromogranin, CD56, Ki-67 immunostaining morphometric analysis performed. Patients included three female males, mean age was 53.3 years. The...
Urothelial carcinoma (UC) is the most common histologic type of urinary bladder cancer, and muscle-invasive UC shows aggressive behaviors. Programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockades have been approved as standard treatments for patients with advanced stage UC. A total 166 cancer (MIBC) patients, who underwent transurethral resection or cystectomy from 2004 to 2010 were included. We evaluated PD-L1 expression by SP142 SP263 assays classified cases “positive”...
Abstract Objectives Urine cytology is the most widely used noninvasive screening tool for urothelial carcinoma diagnosis and surveillance. Although highly specific, urine exhibits suboptimal sensitivity. This study aimed to determine whether hTERT immunocytochemistry (ICC) could be applicable as an ancillary test in routine practice. Methods A total of 561 urinary tract samples were initially screened this study. All them prepared using SurePath liquid‐based (LBC), while additional LBC...
Immunohistochemical (IHC) staining for CK5/6 and CK20 was reported to be correlated with the prognosis of early urothelial carcinoma in a way contrary that advanced tumors unknown reasons. We aimed characterize gene expression profiles subgroups non-muscle-invasive papillary high-grade upper tract (UTUC) classified by levels: group 1 (CK5/6-high/CK20-low), 2 (CK5/6-high/CK20-high), 3 (CK5/6-low/CK20-high). Expression predictive worse UTUC. Transcriptional analysis revealed 308 differentially...
The replication independent (RI) histone H2A.Z is one of the more extensively studied variant members core H2A family, which consists many dependent (RD) members. protein has been shown to be indispensable for survival, and involved in multiple roles from DNA damage chromosome segregation, replication, transcription. However, its functional involvement gene expression controversial. Moreover, several groups metazoan organisms two main isoforms (H2A.Z-1 H2A.Z-2) that differ a few (3–6) amino...
A number of urinary bladder urothelial carcinoma (UB UC) mRNA-based classification systems have been reported. It also has observed that treatment response and prognosis are different for each molecular subtype. In this study, cytokeratin (CK)5/6 CK20 immunohistochemistry (IHC) were performed, IHC-based subgroup was applied. UB UC classified into CK5/6 single-positive (SP), SP, double-positive (DP) double-negative (DN) subgroups, transcriptional analysis performed. The results gene ontology...