A5101668352- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Head and Neck Surgical Oncology
- Craniofacial Disorders and Treatments
- Bone and Joint Diseases
- Respiratory and Cough-Related Research
- Protein Kinase Regulation and GTPase Signaling
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Cleft Lip and Palate Research
- Gastric Cancer Management and Outcomes
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Cardiac tumors and thrombi
- Bone health and treatments
- Pediatric health and respiratory diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Curcumin's Biomedical Applications
- Bone Metabolism and Diseases
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Allergic Rhinitis and Sensitization
- Quinazolinone synthesis and applications
- Liver physiology and pathology
- Receptor Mechanisms and Signaling
Hallym University Sacred Heart Hospital
2019-2022
Hallym University
2019-2020
Catholic University of Korea
2006-2015
Seoul National University
2011
Center for Biologics Evaluation and Research
1990
Gastric cancer is more open related to genetic predisposition. In our RNA sequencing study on gastric patients, Runt-related transcription factor-3 (RUNX3) expression was significantly down-regulated in cancer. We showed that decreased levels of RUNX3 are associated with c-MET (r = − 0.4216, P 0.0130). addition, a candidate for targeted therapy Therefore, the present study, anti-cancer effects inhibitor cells from positive or negative amplification were evaluated. INC280 treatment inhibits...
Sinus pericranii is a rare venous anomaly, which shows abnormal communication between the intracranial and extracranial systems. Sonograms of sinus in 4 children were retrospectively reviewed to evaluate following imaging findings: overall sonographic appearance, change size shape, Doppler flow pattern, associated anomalies. All patients had irregularly shaped anechoic lesions with lobulating bulging contours. They all showed through calvarial defect. Two changes sizes shapes lesions, 2...
RING finger protein 43 (RNF43) encodes the transmembrane E3 ubiquitin ligase, which targets Wnt receptor Frizzled (FZD). RNF43 mutations have been discovered in various human cancers including colon, pancreatic, stomach, ovarian, and liver cancers. Functional studies on missense shown that they negatively regulate signaling; however, there are few functional frameshift mutations. In this study, we showed R117fs P441fs mutants enhanced Wnt/β-catenin signaling, whereas Q409fs G659fs retained...
ABSTRACT Anaplastic lymphoma kinase (ALK) fusion events lead to constitutive activation of the ALK domain, thereby functioning as oncogenic drivers. These proteins have been identified in numerous cancers. Crizotinib, a small molecule inhibitor c-Met and ALK, is Food Drug Administration-approved drug with reported efficacy treatment cancer. Tropomyosins (TPMs) are family actin filament-binding proteins. Altered TPM expression has found variety human tumors. Inhibitors cancer-associated TPMs...
Purpose: Acute asthma exacerbations in children have seasonal variations and occur frequently fall. Respiratory viral infections environmental allergens are associated with exacerbation. This study aimed to identify trends of exac-erbation the effects respiratory infection allergen sensitization on seasonality exacerbation children. Methods: Children under age 18 years who visited Emergency Department or hospitalized for acute exacerba-tions from 2011 2019 were included. We reviewed medical...
Purpose Although CD30 is known to be expressed more on eosinophils undergoing apoptosis, it still not how activation leads eosinophil apoptosis. In this study, we evaluated whether ligation of incites apoptosis and investigated the mechanisms induced are dependent caspase activation. Methods We drew 90 mL peripheral blood from healthy donors then purified using a MACS system. Expression was measured, were cultured in wells pretreated with anti-CD30 mAb, isotype control immunoglobulin G1,...