A5000598094- Alzheimer's disease research and treatments
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mitochondrial Function and Pathology
- Cholinesterase and Neurodegenerative Diseases
- Cardiac Fibrosis and Remodeling
- Mast cells and histamine
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Dermatology and Skin Diseases
- 14-3-3 protein interactions
- NF-κB Signaling Pathways
- Cancer Cells and Metastasis
- Biochemical effects in animals
- Asthma and respiratory diseases
- Cancer Genomics and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Cytokine Signaling Pathways and Interactions
- Genetics, Aging, and Longevity in Model Organisms
- Genetic factors in colorectal cancer
- Vitamin C and Antioxidants Research
- GABA and Rice Research
- Cancer Mechanisms and Therapy
- Cardiovascular Effects of Exercise
- Genomics, phytochemicals, and oxidative stress
Ajou University
2021-2024
Hallym University Sacred Heart Hospital
2020-2022
Sungkyunkwan University
2016-2019
Kangdong Sacred Heart Hospital
2012
Hallym University
2012
Gwangju Institute of Science and Technology
2007-2010
Excessive mitochondrial fission is a prominent early event and contributes to dysfunction, synaptic failure, neuronal cell death in the progression of Alzheimer's disease (AD). However, it remains be determined whether inhibition excessive beneficial mammal models AD. To determine dynamin-related protein 1 (Drp1), key regulator fragmentation, can disease-modifying therapeutic target for AD, we examined effects Drp1 inhibitor on dysfunctions induced by oligomeric amyloid-β (Aβ) neurons...
Significance Considering that Alzheimer’s disease (AD) is a chronic progressing over long period of time, even slight increase BACE1 expression may have profound effect on Aβ accumulation. We describe previously unknown mechanism negatively regulates and BACE1-AS demonstrate its pivotal role in the progression Tau pathologies cognitive impairment two mouse models AD. Given recent failures clinical trials using enzymatic inhibitors BACE1, it critical to explore alternative approaches such as...
Abstract Notch signaling pathways modulate various cellular processes, including cell proliferation, differentiation, adhesion and communication. Recent studies have demonstrated that Notch1 also regulates hepatic glucose production lipid synthesis. However, the effect of on oxidation has not yet been directly investigated. To define function in metabolism, wild type mice deficient antisense transgenic (NAS) were fed a high-fat diet. High-fat diet -fed NAS exhibited marked reduction...
CD44 isoforms are highly expressed in cancer stem cells, initiating tumor growth and sustaining self-renewal. Among these isoforms, variant 9 (CD44v9) is overexpressed chronic inflammation-induced cancer. the mesenchymal-to-epithelial transition (MET) receptor tyrosine kinase coactivated some gastric cancers (GCs). In this study, we characterized MET expression signaling human GC cell lines analyzed differences susceptibility of to foretinib.We viability rate apoptotic cells using MTS assays...
Right ventricular dysfunction (RVD) is associated with poor prognosis in patients acute pulmonary embolism (APE). Echocardiography and computed tomography (CT)-angiography may be difficult to perform a serial follow up, unlike electrocardiography (ECG). Many ECG findings specific for APE have been reported, many studies found that negative T-waves (NTW) precordial leads are most frequently observed APE. We analyzed changes NTW detect RVD predict the recovery of APE.We examined 81 consecutive...
Inhibition of Notch signalling has shown anti-inflammatory properties in vivo and vitro models rheumatoid arthritis (RA). The objective this study was to determine whether Notch1 might play a role regulating T-regulatory cells (Tregs) animal RA. Methods: Collagen-induced (CIA) collagen antibody-induced (CAIA) were induced C57BL/6, antisense transgenic (NAS) or DBA1/J mice. We examined pharmacological inhibitors γ-secretase (an enzyme required for activation) antisense-mediated knockdown...
Regression of cardiac hypertrophy and improvement the functional capacity failing hearts have reportedly been achieved by mechanical unloading in work. In this study, was first induced rats transverse aortic constriction then mechanically unloaded relieving after significant had developed. Hypertrophy significantly regressed at cellular molecular levels day 1, 3, 7 relief. Gene profiling analysis revealed that 52 genes out 9,911 probed on a gene array were specifically upregulated during...
Abstract Background Anti‐heat shock protein (HSP) autoantibodies are detected in autoimmune diseases. We sought to ascertain whether anti‐HSP10 IgG is present patients with CSU and elucidate the role of HSP10 pathogenesis. Method Using a human proteome microarray, six potential had higher expression 10 samples compared normal controls (NCs). Among them, autoantibody was quantified by immune dot‐blot assay sera from 86 44 NCs. The serum levels microRNA‐101‐5p were measured effects miR‐101‐5p...
Reactive oxygen species (ROS) are chemically reactive containing molecules. ROS consist of radical including superoxide anion (O2•-) and hydroxyl (•OH) non-radical such as hydrogen peroxide (H2O2), singlet (O2). generated by mitochondrial oxidative phosphorylation, environmental stresses UV or heat exposure, cellular responses to xenobiotics ( Ray et al., 2012 ). Excessive production over antioxidant capacity induces stress which results in harmful effects cell tissue damage. Sufficient...
Chronic spontaneous urticaria (CSU) is a common cutaneous disease caused by mast-cell degranulation. Human β-defensin 2 (HBD2) well-known antimicrobial peptide that also pruritogen inducing vascular permeability via non-IgE-mediated degranulation.We investigated the associations between serum HBD2 levels and clinical characteristics of CSU patients.Serum samples from 124 patients 56 healthy controls were screened for translationally controlled tumor protein (TCTP)_ using ELISA. The activity...
In chronic spontaneous urticaria (CSU), autoimmune thyroid disease is the most common comorbidity, and many CSU patients have immunoglobulin (Ig)E or IgG autoantibodies to peroxidase (TPO). It remains unclear how anti-TPO IgE are linked each other associated with features, activity, therapeutic responses.
Alzheimer’s disease (AD) has characterized neuropathological hallmark. Soluble amyloid beta generated from precursor protein by beta- and gamma-secretase induces neuronal dysfunction cell death. A key event in AD is the cerebral accumulation of senile plaques formed aggregates amyloid-β(Aβ). Aβ results two sequential endoproteolytic cleavages operated on (APP). First, β-secretase (BACE1) cleaves APP at N-terminal end sequence to produce a secreted form APP, named sAPPβ, C-terminal...
γ-secretase mediated Notch-1 signaling induces ischemic neuronal cell death. Hypoxia inducible factor-1α (HIF-1α), a transcription factor of cellular adaption to hypoxia, can interact with Notch and modulate its during hypoxic stress. Overexpression or knockdown NICD HIF-1α in focal cerebral ischemia/reperfusion model using three-month-old C57BL/6J male mice. We found that inhibitor protect primary cortical neurons under ischemia-like conditions, combined inhibition further reduced...
Amyloid hypothesis postulated that exceed extracellular amyloid beta deposits are the fundamental cause of Alzheimer's disease. is produced by sequential proteolysis to precursor protein (APP) beta-secretase (BACE1) and gamma-secretase. Another important phenomenon in AD patient increased BACE1 expression. Our strategy find specific drugs reducing expression rather than direct inhibition BACE1. Using USA FDA approved drug library (Prestwick Chemical Library), we could discover putative...
Since Janoff introduced novel strategy in 1964, preconditioning has been an attractive for protecting neurons by enhancing cellular tolerance. Abundant studies have shown possible links between low levels of brain-derived neurotrophic factor (BDNF) and neurodegenerative diseases such as Parkinson’s disease, Huntington’s Alzheimer’s disease (AD). Recombinant BDNF protective functions on vitro vivo AD models. We cultured primary rat neuron cell with 100nM Aβ preconditioning. MTT(2.5mg/ml)...
The peptidyl-prolyl cis/trans isomerase Pin1 regulates factors involved in control of cell growth and apoptosis. Notch1 is a transmembrane receptor that plays crucial role neurogenesis neuronal death. Overexpression knockdown vitro mice stroke model. increased γ-secretase activity NICD levels, potentiated death ischemia-like condition. By contrast, using siRNA or knockout reduced the level ischemic Also, we found affected by focal ischemia-reperfusion. stimulates activation its pro-apoptotic...
Alzheimer’s disease (AD) is an age-related disorder characterized by deposition of neurotoxic form beta-amyloid (Aβ) and degeneration neurons. In the brain, accumulation Aβ in mitochondrial compartment has a responsible role impairing physiological functions. Impaired regulation dynamics, which shifts balance towards fission, associated with neuronal death neurodegenerative diseases, such as AD. We investigated effect inhibition mitochondial fission protein Drp1 (dynamin-related prtein 1)...
Recent findings have provided insights into a newly discovered inflammatory mechanism that contributes to the pathogenesis of Alzheimer's disease mediated by multi-protein complexes called NLRP inflammasomes. Oral treatment natural compound isolated from Antartic lichen Ramalina terebrata transgenic APP/PS1 mice and 3xTg-AD mice. injection this reversed transgene-associated behavioral deficits, but did not alter wild-type mouse behaviors. Aβ depositions as well abundance various Ab species...
Extensive epidemiological studies have shown that unexplained loss of weight is associated with the Alzheimer’s disease (AD) but underlying mechanism remains obscure. Currently, several suggest possibilities hormones secreted from adipocytes may roles in pathogenesis AD. Adiponectin,adipocyte-derived bioactive protein, which specifically expressed adipose tissue has attracted attention recent years as therapeutic target for metabolic syndrome. Measuring adiponectin expression level brains 12...