A5029672982- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Advanced X-ray and CT Imaging
- Renal cell carcinoma treatment
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Gallbladder and Bile Duct Disorders
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Prostate Cancer Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Bladder and Urothelial Cancer Treatments
- Lymphoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Vehicle Dynamics and Control Systems
- Color perception and design
Mayo Clinic
2016-2025
Japanese Foundation For Cancer Research
2024-2025
Saitama Cancer Center
2019-2025
Mayo Clinic in Arizona
2015-2024
Saitama Medical University
2004-2024
Niigata University
2001-2024
Osaka Red Cross Hospital
2014-2024
The Cancer Institute Hospital
2024
Chuo University
2003-2023
Tokyo City University
2012-2023
To determine the sensitivity and specificity of elevated serum IgG4 level for diagnosis autoimmune pancreatitis (AIP) its ability to distinguish AIP from pancreatic cancer, main differential diagnosis.We measured levels (normal 8-140 mg/dL) in 510 patients including 45 with AIP, 135 62 no disease, 268 other diseases.Sensitivity, specificity, positive predictive values (>140 were 76%, 93%, 36%, respectively, 53%, 99%, 75%, >280 mg/dL. Among subjects IgG4, non-AIP (N = 32) differed 34) that...
Drug-induced autoimmune hepatitis (DIAIH) has been reported to be caused by several drugs. There is a lack of data comparing these patients with other (AIH). A search was performed using the Mayo Clinic diagnostic medical index for AIH and DIAIH identified over 10 years. Individuals overlap syndromes decompensated liver disease were excluded. Overall, 261 (204 females, median age 52) identified, 24 (9.2%) cases 53 (interquartile range, 24-61). Two drugs, nitrofurantoin (n = 11) minocycline...
IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serologic, radiologic, and pathologic data is required for diagnosis. This work was undertaken to develop validate an international set of classification criteria IgG4-RD.An multispecialty group 86 physicians assembled by the American College Rheumatology (ACR) European League Against Rheumatism (EULAR). Investigators used consensus exercises, existing literature, derivation...
There is a paucity of data on long-term management type 1 autoimmune pancreatitis (AIP), relapsing steroid-responsive disorder.We describe our experience with treatment relapses and maintenance remission using steroid-sparing immunomodulators (IMs) induction rituximab (RTX).We obtained details disease relapse in 116 AIP patients from clinic visits, medical records telephone interviews. We compared free survival those treated IMs versus steroids alone, assessed patients' response to RTX,...
IgG4-related systemic disease is an autoimmune that was first recognized in the pancreas but also affects other organs. This may manifest as tubulointerstitial nephritis (IgG4-TIN), its clinicopathologic features kidney are not well described. Of 35 patients with IgG4-TIN whose renal tissue specimens we examined, 27 (77%) had acute or progressive chronic failure, 29 (83%) involvement of organ systems, and 18 23 (78%) radiographic abnormalities. Elevated total IgG IgG4 serum levels were...
MR Elastography of Liver Tumors: Preliminary ResultsSudhakar K. Venkatesh1 2, Meng Yin1, James F. Glockner1, Naoki Takahashi1, Philip A. Araoz1, Jayant Talwalkar3 and Richard L. Ehman1Audio Available | Share
Purpose To develop and evaluate a fully automated algorithm for segmenting the abdomen from CT to quantify body composition. Materials Methods For this retrospective study, convolutional neural network based on U-Net architecture was trained perform abdominal segmentation data set of 2430 two-dimensional examinations tested 270 examinations. It further separate 2369 patients with hepatocellular carcinoma (HCC). were performed between 1997 2015. The mean age 67 years; male patients, it years...
The aim of this study was to compare <sup>11</sup>C-choline PET/CT with pelvic multiparametric MR imaging for detection recurrent prostate carcinoma in patients suspected recurrence after radical prostatectomy and identify an optimal method restage these patients. <b>Methods:</b> This a retrospective, single-institution 115 tumor who underwent both endorectal coil. reference standard included histopathology, treatment change, follow-up determination locally tumor, lymph node (LN) metastases,...
Experience with minimal access, transoral/transmural endoscopic drainage/debridement of walled-off pancreatic necrosis (WOPN) after necrotizing pancreatitis is limited. We sought to determine outcome using this technique.Retrospective analysis.From 1998 2006, 53 patients underwent sterile (27, 51%) and infected (26, 49%) WOPN. Intervention was performed a median 49 days (range, 20-300 days) onset acute pancreatitis. A 3 procedures/patient 1-12) were performed. Twenty-one (40%) required...
To retrospectively evaluate computed tomographic (CT) and magnetic resonance (MR) imaging renal findings at clinical presentation, during treatment, follow-up in patients with autoimmune pancreatitis (AIP).This HIPAA-compliant study received institutional review board approval. All included had previously consented to the use of their medical records for purpose research. Forty-five (38 male seven female patients; mean age, 64 years) diagnosis AIP were included. Forty underwent CT or MR...
BACKGROUND AND AIMS Recent consensus guidelines suggest that presence of ≥1 the following is an indication for resection (IR) branch duct intraductal papillary mucinous neoplasm (IPMN-Br): cyst-related symptoms, main pancreatic diameter ≥10 mm, cyst size ≥30 intramural nodules, or fluid cytology suspicious/positive malignancy. Among a cohort patients with IPMN-Br we determined if IR (CIR), multifocal IPMN-Br, growth on follow-up predict METHODS We identified 147 whom 66 underwent surgical at...
Cloning and nucleotide sequence determination suggest that the rearranged gamma 1-chain gene in a 1-chain-producing myeloma a-pears to be formed by recombination between 5' flanking regions of 1- mu-chain genes undifferentiated cells. The site is distinct from putative J region novel we call S region. We have extended our previous model explains heavy-chain class switching two or more successive events.
To determine whether a combination of magnetic resonance (MR) parameters can help differentiate small angiomyolipomas (AMLs) without visible fat from renal cell carcinomas (RCCs).This HIPAA-compliant retrospective study received institutional review board approval; 69 men and 42 women (mean age, 59.7 years) with 15 AMLs 104 RCCs underwent MR. The development set consisted 10 71 RCCs; the validation five 33 RCCs. T1-weighted fast spin-echo (SE), fat-suppressed T2-weighted SE, in-...
Elevated serum immunoglobulin G4 (sIgG4) is a feature of autoimmune pancreatitis (AIP) and IgG4-associated cholangitis (IAC); >2-fold increase in sIgG4 considered highly specific for these disorders. Many patients with IAC present biliary strictures obstructive jaundice, making cholangiocarcinoma (CCA) an important differential diagnosis. We determined the value distinguishing from CCA. levels were measured test cohort 126 CCA 50 patients. The results confirmed validation 161 47 Of cohort,...