A5024051594- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Cardiac Fibrosis and Remodeling
- Gallbladder and Bile Duct Disorders
- Advanced Chemical Sensor Technologies
- Liver Diseases and Immunity
- Cancer Cells and Metastasis
- Heavy Metal Exposure and Toxicity
- Pancreatitis Pathology and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Diagnosis and Treatment
- Trace Elements in Health
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Gastrointestinal disorders and treatments
- Amoebic Infections and Treatments
- Drug Transport and Resistance Mechanisms
- Neuroendocrine Tumor Research Advances
King Chulalongkorn Memorial Hospital
2016-2025
Thai Red Cross Society
2015-2025
Chulalongkorn University
2016-2025
WinnMed
2011-2022
Mayo Clinic
2011-2022
Mahidol University
2017
Bangkok Hospital
2017
Creative Research Enterprises (United States)
2017
Mahidol Oxford Tropical Medicine Research Unit
2017
Mayo Clinic in Arizona
2011-2015
Elevated serum immunoglobulin G4 (sIgG4) is a feature of autoimmune pancreatitis (AIP) and IgG4-associated cholangitis (IAC); >2-fold increase in sIgG4 considered highly specific for these disorders. Many patients with IAC present biliary strictures obstructive jaundice, making cholangiocarcinoma (CCA) an important differential diagnosis. We determined the value distinguishing from CCA. levels were measured test cohort 126 CCA 50 patients. The results confirmed validation 161 47 Of cohort,...
The COVID-19 vaccines provide renewed hope in the fight against recent pandemic. To ensure widespread vaccination, it is crucial to analyze vaccine willingness and its determinants among physicians, key health care influencers. This study aimed assess acceptance rate identify factors associated with hesitancy Thai physicians.A cross-sectional online-based questionnaire was distributed all physicians at King Chulalongkorn Memorial Hospital during March 31, 2021 April 30, order their attitudes...
Abstract Volatile organic compounds (VOCs) profile for diagnosis and monitoring therapeutic response of hepatocellular carcinoma (HCC) has not been well studied. We determined VOCs in exhaled breath 97 HCC patients 111 controls using gas chromatography–mass spectrometry Support Vector Machine algorithm. The combination acetone, 1,4-pentadiene, methylene chloride, benzene, phenol allyl methyl sulfide provided the highest accuracy 79.6%, with 76.5% sensitivity 82.7% specificity training set;...
Acute liver failure (ALF) is uncommon but progresses rapidly with high mortality. We investigated the incidence, etiologies, outcomes, and predictive factors for 30-day mortality in patients ALF. conducted a population-based study of ALF hospitalized between 2009 2013 from Thai Nationwide Hospital Admission database, which comprises 76% all admissions 858 hospitals across 77 provinces Thailand. was diagnosed using ICD-10 codes K72.0 K71.11. Patients cirrhosis were excluded. There 20,589...
BACKGROUND Liver injury in patients with dengue infection is common. Most have mild and transient hepatitis. Acute liver failure (ALF) rare but results an extremely poor prognosis. AIM To identify prognostic predictors of ALF death dengue-induced severe hepatitis (DISH). METHODS We retrospectively reviewed 2311 serologically confirmed adolescent adult who were hospitalized during a 12-year study period (between 2007 2019) at the university hospital King Chulalongkorn Memorial Hospital,...
Volatile organic compound (VOC) profiles as biomarkers for hepatocellular carcinoma (HCC) are understudied. We aimed to identify VOCs from the exhaled breath HCC diagnosis and compare performance of alpha-fetoprotein (AFP). The predicting treatment response association between level survival patients were also determined.VOCs 124 219 controls identified using XGBoost algorithm. ROC analysis was used determine in differentiating discriminating responders non-responders. analyzed Cox...
Background & Aims: Non-invasive tests (NITs), e.g. Fibrosis-4 Index (FIB-4) and vibration-controlled elastography (VCTE), have been used to identify metabolic dysfunction-associated steatotic liver disease (MASLD) patients at high risks for hepatocellular carcinoma (HCC). This study investigates the cost-effectiveness of NITs MASLD with advanced fibrosis initiate HCC surveillance. Methods: A cost-utility analysis using a Markov model compared no use three NIT strategies: 1) FIB-4 VCTE...
Background: Portal venous circulating tumor cells (CTCs) detection may better reflect vascular metastasis and predict micro-metastasis risk in PDAC than peripheral blood. We hypothesize that portal CTCs could represent survival patients. Methods: A single-center, prospective cohort study of patients with stage I-III was conducted. blood obtained via EUS-guided sampling, collected on the same day. were detected using EpCAM mucin1 antibodies reported as cells/8mL Results: Among 35 patients,...
Artificial intelligence (AI) using a convolutional neural network (CNN) has demonstrated promising performance in radiological analysis. We aimed to develop and validate CNN for the detection diagnosis of focal liver lesions (FLLs) from ultrasonography (USG) still images. The was developed with supervised training method 40,397 retrospectively collected images 3,487 patients, including 20,432 FLLs (hepatocellular carcinomas (HCCs), cysts, hemangiomas, fatty sparing, infiltration). AI...
Short-chain fatty acids (SCFAs) are involved in important physiological processes such as gut health and immune response, changes SCFA levels can be indicative of disease. Despite the importance SCFAs human disease, reference values for fecal plasma concentrations healthy individuals scarce. To address this gap current knowledge, we developed a simple reliable derivatization-free GC-TOFMS method quantifying individuals. We targeted six linear- seven branched-SCFAs, obtaining recoveries...
AIMTo identify the potential risk factors of cholangiocarcinoma, we determined characteristics cholangiocarcinoma patients among 5 different regions Thailand. METHODSAll diagnosed with between 2008 and 2013 were identified using Nationwide Hospital Admission Data registry (n = 39421).Baseline characteristics, comorbidities survival abstracted. RESULTSThe annual incidence during study period was stable in all regions.Most lived Northeast (62.8%), followed by North (16.9%),Central...
Tyrosinemia type I (TYRSN1, TYR I) is caused by fumarylacetoacetate hydrolase (FAH) deficiency and affects approximately one in 100,000 individuals worldwide. Pathogenic variants FAH cause TYRSN1, which induces cirrhosis can progress to hepatocellular carcinoma (HCC). TYRSN1 characterized the production of a pathognomonic metabolite, succinylacetone (SUAC) included Recommended Uniform Screening Panel for newborns. Treatment intervention effective if initiated within first month life. Here,...
The albumin-bilirubin (ALBI) score is an index of liver function recently developed to assess prognosis in patients with hepatocellular carcinoma (HCC). It can detect small changes dysfunction and has been successfully applied the prediction survival non-malignant diseases various etiologies.To investigate ALBI for identifying decompensation risk at 3-year follow-up compensated cirrhosis.One-hundred twenty-three cirrhosis without HCC King Chulalongkorn Memorial Hospital diagnosed by imaging...