A5039568103- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Alcohol Consumption and Health Effects
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Eosinophilic Esophagitis
- Inflammatory Bowel Disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Mycobacterium research and diagnosis
- Gastrointestinal motility and disorders
- Colorectal Cancer Screening and Detection
- Diagnosis and treatment of tuberculosis
- Gastrointestinal Tumor Research and Treatment
Siriraj Hospital
2016-2025
Mahidol University
2016-2025
GTx (United States)
2023-2024
Weatherford College
2020-2021
Thai Health Promotion Foundation
2020
WinnMed
2010-2012
Mayo Clinic
2005-2011
Ege University
2010
Hôpital Jean-Verdier
2010
Université Sorbonne Paris Nord
2010
<h3>Objectives:</h3> The long-term prognosis of non-alcoholic fatty liver disease (NAFLD) in children remains uncertain. We aimed at determining the outcomes and survival with NAFLD. <h3>Design:</h3> Retrospective longitudinal hospital-based cohort study. <h3>Patients:</h3> Sixty-six NAFLD (mean age 13.9 (SD 3.9) years) were followed up for to 20 years a total 409.6 person-years follow-up. <h3>Results:</h3> metabolic syndrome was present 19 (29%) time diagnosis 55 (83%) presenting least one...
Information on the long-term prognosis of nonalcoholic fatty liver disease (NAFLD) is limited. We sought to describe morbidity and mortality patients with NAFLD advanced fibrosis or cirrhosis by prospectively studying 247 such from four international centers (in Australia, USA, UK Italy). Their natural history was then compared 264 HCV infection who were either naïve non-responders treatment. Both cohorts Child-Pugh class A had (stage 3) 4) confirmed biopsy at enrollment. In cohort, followed...
There is limited information on test performance for detecting cholangiocarcinoma in primary sclerosing cholangitis (PSC), particularly when used sequentially. This study aimed to characterize diagnostic of serum carbohydrate antigen 19-9 (CA 19-9), ultrasonography, computed tomography, magnetic resonance imaging, cholangiography, and biliary cytologic techniques PSC. All consecutive patients with PSC were screened followed development from 2000 through 2006. Of 230 patients, 23 developed...
The significance of nonalcoholic fatty liver disease (NAFLD) among patients with diabetes is unknown. We sought to determine whether a diagnosis NAFLD influenced mortality community-based cohort type II mellitus.A total 337 residents Olmsted County, Minnesota mellitus diagnosed between 1980 and 2000 were identified using the Rochester Epidemiology Project Mayo Laboratory Information System, followed for 10.9 + or - 5.2 years (range 0.1-25). Survival was analyzed Cox proportional hazards...
Nonalcoholic fatty liver disease (NAFLD) may have distinct histological features in children and adults, but to date limited data are available on the spectrum significance of lesions pediatric patients. We conducted a multicenter study with well-characterized, biopsy-proven NAFLD (1) assess presence constellation (2) identify clinical laboratory predictors severity. One hundred thirty seen from 1995 2007 five centers United States Canada were studied. Clinical collected. Slides stained...
The recurrence of primary biliary cirrhosis (PBC) in the hepatic allograft may impact patient and graft survival with long-term follow-up. efficacy ursodeoxycholic acid (UDCA) for treatment recurrent PBC after liver transplantation (LT) remains less well known. aims this study were as follows: 1) to determine significance on overall among patients who underwent LT, 2) UDCA LT PBC. A retrospective cohort was conducted 154 at least 1 yr follow-up from 1985 through 2005. total 52 identified....
Cohort studies reported controversial results regarding the long-term prognosis of patients with lean non-alcoholic fatty liver disease (NAFLD) compared to non-lean NAFLD patients. This updated meta-analysis aimed estimate magnitude association between body mass index and all-cause mortality risk in
The biological basis of variability in histological progression nonalcoholic fatty liver disease (NAFLD) is unknown. Dehydroepiandrosterone (DHEA) the most abundant steroid hormone and has been shown to influence sensitivity oxidative stress, insulin sensitivity, expression peroxisome proliferator-activated receptor alpha procollagen messenger RNA. Our aim was determine whether more histologically advanced NAFLD associated with low circulating levels DHEA. Serum samples were obtained...
The clinical significance of steatohepatitis in chronic hepatitis B remains unclear. This study aimed to determine the prevalence and risk factors for B, its correlation with liver fibrosis response antiviral therapy.Liver histopathology 256 consecutive patients serum virus DNA >2000 IU/mL were analysed laboratory characteristics. Virological biochemical responses prospectively assessed 112 treated monotherapy.Hepatic steatosis was observed 38% entire cohort, diagnosed 18% hepatic according...
Objectives: Tricyclic antidepressants could be effective in the treatment of symptoms related to hypersensitive esophagus through their pain-modulating effect. We therefore assessed benefit imipramine patients with esophageal hypersensitivity and functional heartburn. Methods: Patients normal endoscopy findings typical reflux despite standard-dose proton-pump inhibitor therapy underwent 24-h pH-impedance monitoring. established or heartburn were randomly assigned receive 8 weeks either...
A significant proportion of the non-alcoholic fatty liver disease (NAFLD) population is non-obese. Prior studies reporting severity NAFLD amongst non-obese patients were heterogenous. Our study, using data from largest biopsy-proven international registry within Asia, aims to characterize demographic, metabolic and histological differences between obese patients.1812 across nine countries in Asia assessed 2006 2019 pooled into a curated clinical registry. Demographic, evaluated. The...
This randomized trial aimed to compare the effects of moderate-intensity aerobic vs resistance exercise with dietary modification in patients nonalcoholic fatty liver disease (NAFLD).Patients NAFLD were randomly assigned (1:1) a 12-week supervised training program or intervention consisting monthly individual nutritional counseling by dietician. Transient elastography, anthropometry, body composition, cardiorespiratory fitness, biochemistries, and glucose tolerance measured at baseline 12...
Summary Background The precise estimation of cases with significant fibrosis (SF) is an unmet goal in non‐alcoholic fatty liver disease (NAFLD/MASLD). Aims We evaluated the performance machine learning (ML) and non‐patented scores for ruling out SF among NAFLD/MASLD patients. Methods Twenty‐one ML models were trained ( N = 1153), tested 283), validated 220) on clinical biochemical parameters histologically‐proven patients 1656) collected across 14 centres 8 Asian countries. Their detecting...
Background & Aims: Non-invasive tests (NITs), e.g. Fibrosis-4 Index (FIB-4) and vibration-controlled elastography (VCTE), have been used to identify metabolic dysfunction-associated steatotic liver disease (MASLD) patients at high risks for hepatocellular carcinoma (HCC). This study investigates the cost-effectiveness of NITs MASLD with advanced fibrosis initiate HCC surveillance. Methods: A cost-utility analysis using a Markov model compared no use three NIT strategies: 1) FIB-4 VCTE...
Sarcopenia, characterized by loss of muscle mass and function, has gained importance in the evaluation cirrhotic patients. Evidence suggests its role adverse clinical outcomes, including minimal hepatic encephalopathy (MHE). This study aimed to investigate association between sarcopenia MHE patients with cirrhosis. We prospectively enrolled outpatients cirrhosis assess using 2019 criteria from Asian Working Group for Sarcopenia. was diagnosed through Psychometric Hepatic Encephalopathy...