A5050046654- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Spondyloarthritis Studies and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Pharmaceutical studies and practices
- Immune Response and Inflammation
- Viral Infections and Immunology Research
- Intramuscular injections and effects
- Healthcare and Venom Research
- Allergic Rhinitis and Sensitization
- HER2/EGFR in Cancer Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Biosimilars and Bioanalytical Methods
- Antibiotics Pharmacokinetics and Efficacy
- Immunotherapy and Immune Responses
- Biomedical Research and Pathophysiology
- Multiple Myeloma Research and Treatments
- Peripheral Neuropathies and Disorders
- Protein Degradation and Inhibitors
- Sphingolipid Metabolism and Signaling
Centre for Human Drug Research
2019-2024
Leiden University Medical Center
2009-2023
Loyola University Medical Center
2013
Reinier de Graaf Hospital
2012
Haga Hospital
2012
Reade
2012
Leiden University
2010
GTx (United States)
2009
Erasmus University Rotterdam
2005
Erasmus MC
2005
Objective To compare clinical and radiological outcomes of four dynamic treatment strategies in recent-onset rheumatoid arthritis (RA) after 5 years follow-up. Methods 508 patients with RA were randomly assigned into strategies: sequential monotherapy; step-up combination therapy; initial prednisone; infliximab. Treatment adjustments made based on 3-monthly disease activity score (DAS) measurements (if DAS >2.4 next step; if ≤2.4 during ≥6 months taper to maintenance dose; <1.6 stop...
<h3>Objectives</h3> To determine the relapse rate after discontinuing treatment in patients with rheumatoid arthritis (RA) sustained clinical remission, to identify predictors of a and evaluate response restarting treatment. <h3>Methods</h3> Five-year data from BeSt study were used, which 508 recent-onset RA randomised into four dynamic strategies, aiming at disease activity score (DAS) ≤2.4. When DAS was <1.6 for ≥6 months, last disease-modifying antirheumatic drug (DMARD) tapered...
<h3>Objective</h3> To describe the disease course after cessation of infliximab in early rheumatoid arthritis patients with activity score (DAS)-steered treatment and to identify predictors persistent low activity. <h3>Methods</h3> In a post-hoc analysis BeSt study, joint damage progression were observed treated methotrexate plus infliximab, who discontinued achieving (DAS ≤2.4) for 6 months. Predictors identified using Cox regression analysis. <h3>Results</h3> 104 whom 77 had received as...
Objective To compare nine disease activity indices and the new American College of Rheumatology (ACR)/European League against Rheumatism (EULAR) remission criteria in rheumatoid arthritis (RA) to relate these physical function joint damage progression. Methods Five-year data from BeSt study were used, a randomised clinical trial comparing four treatment strategies 508 patients with recent-onset RA. Every three months was assessed (Disease Activity Score (DAS), DAS-C reactive proteine...
<h3>Objective</h3> To evaluate the effect of disease activity and antirheumatic treatment on blood pressure (BP) in patients with recent-onset rheumatoid arthritis (RA). <h3>Methods</h3> 508 RA were randomised to receive (1) sequential monotherapy, (2) step-up combination therapy, (3) initial prednisone or (4) infliximab. Systolic diastolic BP (SBP, DBP), score (DAS) body mass index (BMI) evaluated every 3 months. A linear mixed model was used SBP DBP each group during year 1, adjusting for...
Objectives. To compare the prevalence of and predictors for sustained drug-free remission in two cohorts patients with recent-onset RA treated DAS-driven therapy or non-DAS-driven therapy. Methods. Sustained was assessed after 5 years follow-up 508 (DAS ≤ 2.4) a randomized treatment cohort, 424 who received prospective inception cohort. The design cohort required systematic joint assessments restart Predictors were identified by univariable multivariable logistic regression each separately...
Abstract This study evaluated and characterized the pharmacological activity of orally administered interleukin‐1 receptor‐associated kinase 4 (IRAK4) inhibitors BAY1834845 (zabedosertib) BAY1830839 in healthy male volunteers. Participants received one either IRAK4 or a control treatment (prednisolone 20 mg placebo) twice daily for 7 days. Localized skin inflammation was induced by topical application imiquimod (IMQ) cream 3 days, starting at Day treatment. The inflammatory response laser...
Objectives To assess the relationship between joint tenderness, swelling and damage progression in individual joints to evaluate influence of treatment on these relationships. Methods First-year data Behandel Strategieën (BeSt) study were used, which patients recently diagnosed as having rheumatoid arthritis (RA) randomly assigned into four different strategies. Baseline 1-year x-rays hands feet assessed using Sharp–van der Heijde score (SHS). With generalised estimating equations, 3-monthly...
Joint destruction in rheumatoid arthritis (RA) was until recently seen as an irreversible state. Lately, it found that repair of bone erosions occurs; however, little is known about its prevalence.To investigate the frequency and patients' characteristics associated with inception cohort.250 patients RA, included Leiden Early Arthritis Clinic between 1993 2000 treated conventional disease-modifying antirheumatic drugs, were studied (mean follow-up 10.1 years). Radiographs obtained annually...
To investigate whether accelerated hand bone mineral density (BMD) loss is associated with progressive joint damage in hands and feet the first year of rheumatoid arthritis (RA) it an independent predictor subsequent total after 4 years. In 256 recent-onset RA patients, baseline 1-year BMD was measured metacarpals 2-4 by digital X-ray radiogrammetry. Joint were scored random order according to Sharp-van der Heijde method at yearly up 68% patients had (>-0.003 g/cm2) RA. Hand 1 both odds...
Objective To evaluate the contribution of joint space narrowing (JSN) and erosions in general four different groups relation to physical disability rheumatoid arthritis (RA). Methods 5-year follow-up data from Behandel Strategieën (BeSt) trial were used, where 508 patients with recent onset RA treated aiming at a disease activity score ≤2.4. Joint damage was assessed annually scored according Sharp-van der Heijde method. Physical measured 3-monthly Health Assessment Questionnaire (HAQ)....
To assess the relationship between a decrease in disease activity score (DAS) and functional ability during 5 years of DAS-steered treatment recent-onset rheumatoid arthritis (RA) patients, taking into account absolute DAS levels follow-up duration.Data from BeSt study were used, which was aimed at achieving ≤2.4. The longitudinal 3-monthly measured health assessment questionnaire (HAQ) assessed using linear mixed modelling treatment, with HAQ 3 months earlier, change last (delta DAS), time...
Concentrations of drugs acting in the lungs are difficult to measure, resulting relatively unknown local pharmacokinetics. The aim this study is assess potential exhaled breath condensate (EBC) as a matrix for pharmacokinetic analysis inhaled and intravenous medication. A 4‐way crossover was conducted 12 volunteers with tobramycin salbutamol intravenously via inhalation. EBC plasma samples were collected postdose analysed drug concentrations. Sample dilution, calculated using urea...
ABSTRACT Psoriasis is an inflammatory skin disease associated with impaired barrier. The barrier function dependent on the extracellular lipid matrix which surrounds corneocytes in stratum corneum. Ceramides comprise essential components of this matrix. Alterations corneum ceramide profile have been directly linked to dysfunction and might be underlying factor impairment psoriasis. In study, we investigated Lesional non‐lesional 26 patients 10 healthy controls were analysed using in‐depth...
Abstract Based on its wide range of immunosuppressive properties, hydroxychloroquine (HCQ) is used for the treatment several autoimmune diseases. Limited literature available relationship between HCQ concentration and effect. To gain insight in this relationship, we performed vitro experiments human PBMCs explored effect T B cell proliferation Toll-like receptor (TLR)3/TLR7/TLR9/RIG-I-induced cytokine production. In a placebo-controlled clinical study, these same endpoints were evaluated...
Imiquimod (IMQ) is a topical agent that induces local inflammation via the Toll-like receptor 7 pathway. Recently, an IMQ-driven skin model was developed in healthy volunteers for proof-of-pharmacology trials. The aim of this study to profile cellular, biochemical, and clinical effects marketed anti-inflammatory compound prednisolone IMQ model. This randomized, double-blind, placebo-controlled conducted 24 volunteers. Oral (0.25 mg/kg/dose) or placebo (1:1) administered twice daily 6...