A5075402055- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Viral Infections and Outbreaks Research
- Vaccine Coverage and Hesitancy
- Autism Spectrum Disorder Research
- Computational Drug Discovery Methods
- Mosquito-borne diseases and control
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- CAR-T cell therapy research
- Musculoskeletal pain and rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Influenza Virus Research Studies
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Neonatal Respiratory Health Research
- Drug-Induced Hepatotoxicity and Protection
- Biochemical and Structural Characterization
- Tracheal and airway disorders
- Bacterial Infections and Vaccines
Centre for Human Drug Research
2019-2024
Leiden University Medical Center
2020-2024
Leiden University
2019
Abstract Background α‐Synuclein (αSyn) is believed to play a central role in Parkinson's disease (PD) neuropathology and considered target for modification. UB‐312 synthetic αSyn peptide conjugated T helper expected induce antibodies specifically against oligomeric fibrillar αSyn, making potential immunotherapeutic synucleopathies. Objective To investigate the safety, tolerability, immunogenicity of vaccination healthy participants determine safe immunologically optimal dose first‐in‐patient...
Human respiratory syncytial virus (RSV) is a major cause of lower tract infections in early infancy and elderly. A pediatric vaccine against RSV would not only prevent morbidity mortality amongst infants young children but could also reduce transmission to The RSVΔG consists live-attenuated that lacks the G attachment protein. severely impaired binding host cells exhibits reduced infectivity preclinical studies. Intranasal immunization cotton rats with protected replication wildtype RSV,...
Abstract Based on its wide range of immunosuppressive properties, hydroxychloroquine (HCQ) is used for the treatment several autoimmune diseases. Limited literature available relationship between HCQ concentration and effect. To gain insight in this relationship, we performed vitro experiments human PBMCs explored effect T B cell proliferation Toll-like receptor (TLR)3/TLR7/TLR9/RIG-I-induced cytokine production. In a placebo-controlled clinical study, these same endpoints were evaluated...
Aim To assess viral clearance, pharmacokinetics, tolerability and symptom evolution following ensovibep administration in symptomatic COVID‐19 outpatients. Methods In this open‐label, first‐in‐patient study a single dose of either 225 mg (n = 6) or 600 was administered intravenously outpatients with mild‐to‐moderate symptoms. Pharmacokinetic profiles were determined (90‐day period). Pharmacodynamic assessments consisted load (qPCR cultures) questionnaires. Immunogenicity against...
Clinical development of vaccines in a pandemic situation should be rigorous but expedited to tackle the threat as fast possible. We explored effects novel vaccine trial strategy that actively identifies and enrolls subjects local areas with high infection rates. In addition, we assessed practical requirements needed for such strategy. simulations were used assess utilizing these so-called "hot spot strategy" compared traditional field trial. preset parameters outbreak incorporated realistic...
One of the main challenges in early clinical research with respiratory syncytial virus (RSV) live-attenuated vaccines (LAVs) is to assess immunogenicity healthy adults. Healthy adults will have preexisting levels serum neutralizing antibodies that could prematurely neutralize LAV and underestimate potential effect vaccine on immune system. Data prevalence distribution titers (VNTs) limited there no absolute threshold for protection against RSV-infection can serve as an eligibility criterion...
To evaluate self-reported and assessor-reported joint counts for pain their value in measuring activity hand OA patients.
Intranasal administration of respiratory vaccines offers many advantages such as eliciting both systemic and mucosal immunity at the point viral entry. Immunogenicity intranasal vaccination can be improved through use adjuvants. Bacteria-like particles derived fromLactococcus lactishave potential to serve a vaccine adjuvant.This clinical study investigated safety, reactogenicity immunogenicity seasonal influenza adjuvanted with gram-positive matrix (FluGEM®).
Background: M5717 is a novel antimalarial that inhibits Plasmodium falciparum translation elongation factor 2. We investigated the chemoprophylactic activity and dose–exposure–response relationship of single oral doses following direct venous inoculation (DVI) sporozoites in healthy volunteers.Methods: This was phase 1b, randomised, double-blind, placebo-controlled, adaptive, dose-finding, single-centre study (NCT04250363). Eligible, malaria-naïve adults aged 18–45 years were divided into...