A5023734802- Hemoglobinopathies and Related Disorders
- Retinal Imaging and Analysis
- Digital Imaging for Blood Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Thermoregulation and physiological responses
- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Pharmaceutical studies and practices
- Antibiotic Resistance in Bacteria
- Blood groups and transfusion
- Acute Ischemic Stroke Management
- MRI in cancer diagnosis
- Alzheimer's disease research and treatments
- Optical Coherence Tomography Applications
- Peripheral Artery Disease Management
- Neurogenetic and Muscular Disorders Research
- Hematological disorders and diagnostics
- Cerebral Venous Sinus Thrombosis
- Healthcare and Venom Research
- Cell death mechanisms and regulation
- Receptor Mechanisms and Signaling
- ECG Monitoring and Analysis
- Epilepsy research and treatment
- Asthma and respiratory diseases
- Bone and Joint Diseases
Centre for Human Drug Research
2014-2021
Leiden University Medical Center
2018
Receptor‐interacting serine/threonine‐protein kinase 1 ( RIPK1 ) regulates inflammation, cytokine release, and necroptotic cell death is implicated in pathogenic cellular pathways amyotrophic lateral sclerosis ALS ), Alzheimer's disease AD multiple sclerosis. Inhibition of RIPK activity protects against inflammation animal models. DNL 104 a selective, brain‐penetrant inhibitor phosphorylation clinical development for . was tested 68 healthy volunteers to investigate safety tolerability,...
Concentrations of drugs acting in the lungs are difficult to measure, resulting relatively unknown local pharmacokinetics. The aim this study is assess potential exhaled breath condensate (EBC) as a matrix for pharmacokinetic analysis inhaled and intravenous medication. A 4‐way crossover was conducted 12 volunteers with tobramycin salbutamol intravenously via inhalation. EBC plasma samples were collected postdose analysed drug concentrations. Sample dilution, calculated using urea...
Understanding the factors influencing a drug's potential to prolong QTc interval on an electrocardiogram is essential for correct evaluation of its safety profile. To explore effect dosing time drug-induced prolongation, randomized, crossover, clinical trial was conducted in which 12 healthy male subjects received levofloxacin at 02:00, 06:00, 10:00, 14:00, 18:00, and 22:00. Using pharmacokinetic-pharmacodynamic (PK-PD) modeling approach account variations PKs, heart rate, daily variation...
Aim The objective of this study was to investigate whether the pharmacokinetics orally administered levofloxacin show 24 h variation. Levofloxacin used as a model compound for solubility and permeability independent absorption passive renal elimination. Methods In single centre, crossover, open label study, 12 healthy subjects received an oral dose 1000 mg at six different time points equally divided over period. Population pharmacokinetic modelling identify potential variation in parameters...
Tissue necrosis, a consequence of inadequate tissue oxygenation, is common post-operative complication. As current surgical assessments are often limited to visual and tactile feedback, additional techniques that can aid in the interrogation viability needed improve patient outcomes. In this bi-institutional pilot study, performance novel snapshot hyperspectral imaging camera detect superficial cutaneous oxygen saturation (StO2) was evaluated.Healthy human volunteers were recruited at two...
Recombinant human erythropoietin (rHuEPO) has been used as a performance-enhancing agent by athletes in variety of sports. The resulting increase hematocrit levels leads to increased blood viscosity and can affect flow, potentially increasing the athlete's risk developing health complications. However, actual effects using rHuEPO on microvascular flow post-occlusive reactive hyperemia are currently unknown. We therefore evaluated effect cutaneous microcirculation well-trained cyclists laser...
Restoring normal functioning and tissue healing after surgical intervention is, among others, critically dependent on oxygenation perfusion. Tissue necrosis, caused by inadequate perfusion and/or oxygenation, is a common complication reconstruction of e.g. bowel anastomoses or skin defects. Currently, several optical techniques, which do not require administration contrast agents, have been used to evaluate oxygenation. An emerging technique hyperspectral imaging, capable detect the...
Abstract Purpose Fractal analysis can be used to quantitatively analyze the retinal microvasculature and might a suitable method quantify capillary changes in sickle cell disease (SCD) patients. Retinal oximetry measurements function as proxy for pathophysiology of cerebrovascular diseases. Moreover, hypoxia has an important role diabetic other retinopathies. However, little is known about around macula SCD With this study, we explored feasibility perform these quantified Methods...
In the last decade new and more advanced microvascular imaging techniques have become available for use in clinical research. As it became evident that dysfunction might prelude (cardio) vascular events, measurements gained increasing interest their applicability clinic this narrative review we aim to provide an updated oversight of measurement techniques. We made outline most common latest cutaneous retinal included frequently used challenges together with these measurements. Furthermore...