A5010775481- Pancreatic and Hepatic Oncology Research
- Optical Imaging and Spectroscopy Techniques
- Cancer Research and Treatments
- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Hemoglobinopathies and Related Disorders
- Retinal Imaging and Analysis
- Optical Coherence Tomography Applications
- Digital Imaging for Blood Diseases
- Angiogenesis and VEGF in Cancer
- Coronary Interventions and Diagnostics
- Ureteral procedures and complications
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Traumatic Brain Injury and Neurovascular Disturbances
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Thermoregulation and physiological responses
- Colorectal Cancer Surgical Treatments
- Biliary and Gastrointestinal Fistulas
- Legionella and Acanthamoeba research
- Pediatric Hepatobiliary Diseases and Treatments
- Peripheral Artery Disease Management
- Abdominal Surgery and Complications
- Enhanced Recovery After Surgery
Leiden University Medical Center
2017-2023
Leiden University
2018-2021
University Medical Center Utrecht
2013
Purpose: It is suggested that tumour markers carcinoembryonic antigen (CEA) and carbohydrate 19-9 (CA19-9) could be used to predict the stage of pancreatic cancer. However, optimal cut-off values for CEA CA19-9 are disputable. This study aimed assess value serum levels at diagnosis ductal adenocarcinoma (PDAC) as predictors advanced PDAC in patients discussed multidisciplinary team (MDT) meetings.Methods: Patients with suspected MDT meetings from 2013 2017 were reviewed, order determine both...
Molecular fluorescence-guided surgery using near-infrared light has the potential to improve rate of complete resection cancer. Typically, monoclonal antibodies are being used as targeting moieties, however smaller fragments, such single-domain (i.e., Nanobodies®) tumor specificity and enable tracer injection on same day surgery. In this study, feasibility a carcinoembryonic antigen-targeting Nanobody (NbCEA5) conjugated two zwitterionic dyes (ZW800-1 Forte [ZW800F] ZW800-1) for...
This study aimed to determine the stage-specific prognostic value of carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic (CEA) serum levels at diagnosis on overall survival (OS) time local recurrence or distant metastases in patients with pancreatic ductal adenocarcinoma (PDAC). Consecutive PDAC patients, discussed multidisciplinary team meetings from 2013 through 2017, were reviewed. Prognostic factors (resection vs. advanced PDAC) evaluated Cox proportional hazard models. Additionally,...
Background Pancreatic cancer is the fourth leading cause of cancer-related mortality in United States. The minority patients can undergo curative-intended surgical therapy due to progressive disease stage at time diagnosis. Nonetheless, tumor involvement margins seen up 70% resections, being a strong negative prognostic factor. Real-time intraoperative imaging modalities may aid surgeons obtain tumor-free resection margins. Full-field optical coherence tomography (FF-OCT) promising...
A positive urinary antigen test for Legionella spp. (Legionella test; LUAT) allows an early switch from empiric to targeted treatment (TT) in hospitalised, community-acquired pneumonia (CAP) patients. We aimed evaluate the diagnostic, therapeutic and economic consequences of this frequently used 7 years after its implementation.We retrospectively evaluated LUATs performed between 2005 2011 two teaching hospitals. All tests hospitalised CAP patients were evaluation included evaluation. Data...
Abstract Purpose Radical resection is paramount for curative oncological surgery. Fluorescence-guided surgery (FGS) aids in intraoperative identification of tumor-positive margins. This study aims to assess the feasibility urokinase plasminogen activator receptor (uPAR) targeting antibody fragments FGS a direct comparison with their parent IgG various relevant vivo models. Procedures Humanized anti-uPAR monoclonal MNPR-101 (uIgG) was proteolytically digested into F(ab’)2 and Fab named uFab2...
Post cholecystectomy syndrome is characterized as recurrence of symptoms experienced before cholecystectomy. In rare cases, a remnant cystic duct causing these and occasionally surgical resection performed. During surgery, visualization the biliary ducts could be difficult due to inflammation dense adhesions. this article, we presented 36-year old woman with post-cholecystectomy in which evaluated feasibility near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) for common...
Significance: Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has proven to be a feasible application for real-time intraoperative assessment of tissue perfusion, although quantification NIR signals is pivotal standardized perfusion. Aim: Four patients are described with possible compromised bowel perfusion after mesenteric resection. Based on these we want emphasize the difficulties in analysis. Approach: During image-guided assessment, 5 mg ICG (2.5 / ml) was...
Tissue necrosis, a consequence of inadequate tissue oxygenation, is common post-operative complication. As current surgical assessments are often limited to visual and tactile feedback, additional techniques that can aid in the interrogation viability needed improve patient outcomes. In this bi-institutional pilot study, performance novel snapshot hyperspectral imaging camera detect superficial cutaneous oxygen saturation (StO2) was evaluated.Healthy human volunteers were recruited at two...
This study aimed to determine the ability of single fiber reflectance (SFR) spectroscopy incorporated in endoscopic ultrasound fine needle biopsy (EUS-FNB) procedures pancreas distinguish benign and malignant pancreatic tissue patient with masses suspected for malignancy.Methods: was designed as a prospective observational center included consecutive adult patients, who were scheduled EUS-FNB solid mass ductal adenocarcinoma (PDAC).In total, seven optical parameters, derived from absorption...
For solid tumors, such as breast cancer, surgery is usually the treatment of choice. these operations, it utmost importance to remove whole tumor, since tumor-positive resection margins may result in recurrent disease and impaired overall survival. Current optical imaging techniques using endogenous contrast - e.g. diffuse reflectance spectroscopy or coherence tomography – for detection cancers are limited point measurements long acquisition times. Broadband hyperspectral cameras, which...
Restoring normal functioning and tissue healing after surgical intervention is, among others, critically dependent on oxygenation perfusion. Tissue necrosis, caused by inadequate perfusion and/or oxygenation, is a common complication reconstruction of e.g. bowel anastomoses or skin defects. Currently, several optical techniques, which do not require administration contrast agents, have been used to evaluate oxygenation. An emerging technique hyperspectral imaging, capable detect the...
The introduction of optical imaging by using near-infrared (NIR) light shines new in the field (oncologic) surgery. use non-specific fluorophores, such as Indocyanine Green (ICG) and Methylene Blue (MB) have already shown its value for different applications during image-guided Both ICG MB are currently only fluorophores approved regulatory agencies off-label use. improves visibility several solid tumors, sentinel lymph nodes, biliary ducts can be used to evaluate tissue perfusion. could...
Abstract Purpose Fractal analysis can be used to quantitatively analyze the retinal microvasculature and might a suitable method quantify capillary changes in sickle cell disease (SCD) patients. Retinal oximetry measurements function as proxy for pathophysiology of cerebrovascular diseases. Moreover, hypoxia has an important role diabetic other retinopathies. However, little is known about around macula SCD With this study, we explored feasibility perform these quantified Methods...