A5065006148- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Renal Transplantation Outcomes and Treatments
- Pneumonia and Respiratory Infections
- Blood groups and transfusion
- Hepatitis C virus research
- Genital Health and Disease
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis Viruses Studies and Epidemiology
- Platelet Disorders and Treatments
- Tuberculosis Research and Epidemiology
- Hepatitis B Virus Studies
- Cytomegalovirus and herpesvirus research
- Eating Disorders and Behaviors
- Long-Term Effects of COVID-19
- Dermatological and COVID-19 studies
- Infectious Diseases and Tuberculosis
- COVID-19 epidemiological studies
- Antifungal resistance and susceptibility
- Animal Virus Infections Studies
- Erythrocyte Function and Pathophysiology
- COVID-19 and healthcare impacts
Chulalongkorn University
2007-2024
King Chulalongkorn Memorial Hospital
2006-2024
Thai Red Cross Society
2015-2022
Rajavithi Hospital
2008
Abstract In the age of a pandemic, such as ongoing one caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), world faces limited supply tests, personal protective equipment, and factories chains are struggling to meet growing demands. This study aimed evaluate efficacy specimen pooling for testing SARS‐CoV‐2 virus, determine whether costs resource savings could be achieved without impacting sensitivity testing. Ten previously tested nasopharyngeal throat swab specimens...
The COVID-19 vaccines provide renewed hope in the fight against recent pandemic. To ensure widespread vaccination, it is crucial to analyze vaccine willingness and its determinants among physicians, key health care influencers. This study aimed assess acceptance rate identify factors associated with hesitancy Thai physicians.A cross-sectional online-based questionnaire was distributed all physicians at King Chulalongkorn Memorial Hospital during March 31, 2021 April 30, order their attitudes...
Abstract Objectives Human pythiosis is a life-threatening disease for which no standard treatment protocols with proven efficacy exist. We present the results of our institutional protocol, composed surgery, antifungal agents, iron chelator (only vascular cases) and immunotherapy. Methods retrospectively analysed patients ocular in King Chulalongkorn Memorial Hospital from April 2003 to May 2013. Fisher's exact test Wilcoxon's rank-sum were used. The MICs seven agents combination drugs...
We report a case of COVID-19 in kidney transplant patient Thailand. A 58-year-old 2 years post-kidney recipient, with maintenance immunosuppression tacrolimus, mycophenolate mofetil (MMF), and prednisolone, presented acute diarrhea which followed by fever on day 12. Symptoms pneumonia together lymphopenia from complete blood count were developed 7 after onset the x-ray finding bilateral multifocal patchy infiltration. infection has been confirmed reverse real-time polymerase chain reaction...
SARS-CoV-2 infection results in a broad spectrum of clinical outcomes, ranging from asymptomatic to severe symptoms and death. Most COVID-19 pathogenesis is associated with hyperinflammatory conditions driven primarily by myeloid cell lineages. The long-term effects post recovery include various symptoms. We performed longitudinal study the innate immune profiles 1 3 months after Thai cohort comparing patients mild, moderate, using peripheral blood mononuclear cells (n = 62). Significant...
Wastewater-based epidemiology is a valuable tool for population-level pathogen surveillance, complementing clinical methods. While most sampling focuses on municipal wastewater treatment plants, emerging evidence suggests collected from hospital settings can lead to targeted interventions. To investigate surveillance in further, we tracked the presence and concentration of SARS-CoV-2 RNA across multi-scale sample sites within large, public tertiary care Bangkok, Thailand. From July 2022 May...
Inactivated SARS-CoV-2 (CoronaVac®, Sinovac, or SV) and ChAdOx1 nCoV-19 (Vaxzevria®, Oxford-Astra Zeneca, AZ) vaccines have been administered to the health care workers (HCWs).To determine short-term immune response after SV AZ vaccinations in HCWs.In this prospective cohort study, HCWs who completed a 2-dose regimen of were included. Immune was evaluated by surrogate viral neutralization test (sVNT) anti-SARS-CoV-2 total antibody. Blood samples analyzed at 4 12 weeks complete vaccination....
Several studies confirm multiple complications after COVID-19 infection, including men's sexual health, which is caused by both physical and psychological factors. However, focusing on long-term effects among recovered patients are still lacking. Therefore, we aimed to investigate the erectile function at three months recovery along with its predicting factors.We enrolled all male patients, who were hospitalized from May July 2021, declared be sexually active within previous two weeks....
Background The presence of neutralizing antibodies (NAbs) is an indicator protective immunity for most viral infections. A newly developed surrogate neutralization assay (sVNT) offers the ability to detect total receptor binding domain-targeting NAbs in isotype-independent manner, increasing test sensitivity. Thus, specimens with low IgM/ IgG antibody levels showed strong activity sVNT. Methods This study aimed measure %inhibition measured by sVNT PCR-confirmed COVID-19 patients. sensitivity...
Although pertussis has been considered a disease of childhood, it is also recognized as an important respiratory tract infection in adolescents and adults. However, countries with routine vaccination against high coverage, not usually taken into consideration for the etiology prolonged cough Previous studies variety populations developed have documented that quite common, ranging from 2.9 to 32 % adults cough. The anticipation early recognition this change epidemiology because affected act...
Previous studies showed that an immunological response to hepatitis B virus (HBV) vaccination in patients with AIDS was lower than the normal population. However, those virological highly active antiretroviral therapy (HAART) may have a HBV vaccination. In our study, who had HAART and no immunity received 3 doses of vaccine (20 µg Engerix-B®) on d 0, 30, 180. Anti-HBs level measured 1 month after complete Of 28 patients, overall rate 71.4%. The responder group significantly higher CD4 count...
Background: Erectile dysfunction (ED) is suspected to be the symptom manifestation of COVID-19. However, scarce data was presented this day. Our study conducted determine prevalence ED and its associated factors among Thai patients with Methods: Sexually active males COVID-19, hospitalized between May July 2021 at one university hospital in Bangkok, were screened for erectile by International Index Function 5 (IIEF-5). Demographic COVID-19 treatment history collected. Mental health status,...
Wastewater surveillance is considered a promising approach for COVID-19 in communities. In this study, we collected wastewater samples between November 2020 and February 2022 from twenty-three sites the Bangkok Metropolitan Region to detect presence of SARS-CoV-2 its variants comparison standard clinical sampling. A total 215 were tested RNA by real-time PCR with three targeted genes (N, E, ORF1ab); 102 positive (42.5%). The determined multiplex MassARRAY assay distinguish four variants,...
Healthcare workers are considered to be at a higher risk of acquiring tuberculosis (TB) infection than the general population. Clinical medical students part healthcare team and clinical practice done during their rotation. They could exposed similar occupational risks as workers. Most who become infected have latent (LTBI) may not exhibit any symptoms. Some with LTBI can progress TB disease rotations in hospitals. Therefore, screening for this population represents hospital aspect public...
Emerging coronaviruses (CoVs) are understood to cause critical human and domestic animal diseases; the spillover from wildlife reservoirs can result in mild severe respiratory illness humans animals spread more readily these naïve hosts. A low-cost CoV molecular method that detect a variety of CoVs humans, animals, environmental specimens is an initial step ensure early identification known new viruses. We examine collection 50 human, 46 wastewater, 28 bat, 17 avian archived using 3...
Abstract Background Inactivated SARS-CoV-2 (CoronaVac®,Sinovac, or SV) and ChAdOx1 nCoV-19 (Vaxzevria®,Oxford-Astra Zeneca, AZ) vaccines have been administered to the health care workers (HCWs) in Thailand. Objective To determine short-term immune response after SV AZ vaccinations HCWs. Methods In this prospective cohort study, HCWs who completed a 2-dose regimen of were included. Immune was evaluated by surrogate viral neutralization test (sVNT) anti-SARS-CoV-2 total antibody. Blood samples...
SARS-CoV-2 and other respiratory co-infections may occur. As Mycoplasma pneumoniae various viruses can cause cold agglutinin disease (CAD), the presence of CAD in COVID-19 patients should indicate need investigations for those pathogens.
Immunity against SARS-CoV-2 infection in vaccinated individuals varies based on the vaccine type, duration after vaccination or infection, and variant type. We conducted a prospective observational study to evaluate immunogenicity of booster with AZD1222 two doses CoronaVac (booster group) compared who had receiving (infection group). used surrogate virus neutralization test (sVNT) immunity wild-type Omicron (BA.1) at 3 6 months dose. Of 89 participants, 41 were group, 48 group. At...
The emergence of Omicron as the fifth variant concern within SARS-CoV-2 pandemic in late 2021, characterized by its rapid transmission and distinct spike gene mutations, underscored pressing need for cost-effective efficient methods to detect viral variants, especially given their evolving nature. This study sought address this assessing effectiveness two classification platforms based on RT-PCR mass spectrometry. primary aim was differentiate between Delta, BA.1, BA.2 variants using 618...
During the Coronavirus Disease 2019 pandemic, esophagogastroduodenoscopy (EGD) has been recognized as an aerosol-generating procedure. This study aimed to systematically compare degree of face shield contamination between endoscopists who performed EGD on patients lying in left lateral decubitus (LL) and prone positions.This is a randomized trial scheduled for April June 2020. Eligible 212 were with 1:1 allocation. Rapid adenosine triphosphate test was used determine level using relative...
In early January 2020, Thailand became the first country where a coronavirus disease 2019 (COVID-19) patient was identified outside China. this study, 23 whole genomes of severe acute respiratory syndrome 2 (SARS-CoV-2) from patients who were hospitalized to March 2020 analyzed, along with their travel histories. Six lineages including A, A.6, B, B.1, B.1.8, and B.58, among which lineage A.6 dominant. Seven China traveled in February. Five them infected B virus, other two cases different A...