A5034085122- Hemoglobinopathies and Related Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Iron Metabolism and Disorders
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Venous Thromboembolism Diagnosis and Management
- Intramuscular injections and effects
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Multiple Myeloma Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- COVID-19 Clinical Research Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Transplantation: Methods and Outcomes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Antifungal resistance and susceptibility
- Neonatal Health and Biochemistry
- Adenosine and Purinergic Signaling
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Disorders and Syndromes
Chulalongkorn University
2016-2025
King Chulalongkorn Memorial Hospital
2016-2025
Thai Red Cross Society
2010-2024
Naresuan University
2022
Beth Israel Deaconess Medical Center
2017
University College London
2016
University of North Carolina at Chapel Hill
2010
Abstract Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare subtype of peripheral affecting younger patients and associated with hemophagocytic lymphohistiocytosis. To clarify the molecular pathogenesis SPTCL, we analyzed paired tumor germline DNAs from 13 by whole-exome sequencing. All cases were Asians phenotypically sporadic no family history SPTCL. Consistent recent report, mutations in HAVCR2, encoding immunoglobulin mucin 3 (TIM3), identified 11 (85%) cases. mutated...
Background: Hemoglobin (Hb) Hekinan is a prevalent α-globin variant frequently missed in thalassemia screening centers using high-performance liquid chromatography (HPLC) or capillary electrophoresis. This study aims to investigate the hematological and molecular characteristics of Hb large cohort.
Due to rebalanced haemostasis in cirrhosis, viscoelastometric testing (VET) is more accurate than standard coagulation tests (SCTs) preprocedural haemostatic evaluation, resulting decreased unnecessary transfusion. We aimed determine the impact of VET-guided strategy on postprocedural bleeding, periprocedural transfusion rates and quantities, transfusion-related adverse events (TRAEs), lengths stay (LOS) mortality from randomized controlled trials (RCTs) cirrhotic patients.PubMed EMBASE were...
Heparin-induced thrombocytopenia (HIT) is a serious immunological complication of heparin administration. Diagnosis HIT challenging, especially in critically ill patients. The clinical scoring model for predicting helpful guiding decision. We analysed data patients who underwent the heparin-induced platelet aggregation (HPA) test from 2006 to 2010 and compared diagnostic performance novel expert probability ('HEP'), which has been validated population mainly comprising surgical first, by...
We reported three cases of immune thrombocytopenia (ITP) that developed within 6 weeks after ChAdOx1 nCoV-19 vaccination. Antiplatelet factor 4 antibodies were undetectable in all cases. Therefore, vaccine-induced thrombotic was very unlikely. Other potential causes excluded. Their clinical presentations, severity and outcomes varied. Only one ITP case, an 80-year-old man, received treatments achieved complete response 2 eltrombopag. An 84-year-old man had spontaneous remission, a...
Thromboprophylaxis for venous thromboembolism (VTE) failed to reduce overall mortality in hospitalised medical patients. As a VTE prediction model Asians is still lacking, this study aimed identify very high risk patients who would be the main target prevention. In 2009, admitted King Chulalongkorn Memorial hospital, tertiary care centre, were prospectively evaluated factors. The high-risk cohort was monitored symptomatic until six weeks after discharge. No heparin prophylaxis given. Of...
Hemoglobin Constant Spring (HbCS) is an unstable α-globin variant causing α-thalassemia phenotypes. The prevalence of compound heterozygosity for HbCS and deletional α+-thalassemia (HbCS/α+-thal) its characteristics compared with have not been reported. We performed molecular analysis to detect α+-thal alleles in 75 heterozygotes correlated hematological characteristics. There were 34 (45.3%) carrying α+-thal. Hematological parameters HbCS/α+-thal demonstrated lower Hb, MCV, MCH, MCHC than...
Objectives: The outcomes of primary central nervous system lymphoma (PCNSL) are much improved with multi-modality regimens. Unfortunately, in limited-resource countries, chemo-radiotherapy is the only option curative-intent treatment. This study aimed to evaluate effects low-dose whole brain radiotherapy (WBRT) as a consolidation on disease control and long-term neurocognitive functions.Methods: We conducted retrospective single-center enrolling PCNSL patients from 2011 May 2016 real-life...
Chrysosporium species, saprobic soil fungi, comprise more than 60 species. There is some confusion regarding the taxonomy and nomenclature between Emmonsia since causative agents of adiaspiromycosis, development big thick-walled spores (adiaspores) in humans or animals, were previously thought to be Chrysosporium. articulatum has never been reported cause invasive infection humans. We report herein first case pulmonary caused by a 16-year-old man with acute T-cell lymphoblastic leukaemia. He...
Summary. Although natural anticoagulant deficiencies are the established causes of thrombosis, their roles in bleeding not fully studied. The objective is to correlate haemostatic factors with haemorrhagic symptoms quantified by a standardized questionnaire. Adult subjects were recruited from Bangkok and nearby provinces as part routine health surveys/checkups. validated MCMDM‐1VWD form was used assess symptoms. At same time, von Willebrand factor (VWF) activity, free protein S levels C...