A5027656290- Pregnancy and preeclampsia studies
- Single-cell and spatial transcriptomics
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Maternal and fetal healthcare
- Aortic aneurysm repair treatments
- Radiomics and Machine Learning in Medical Imaging
- Genomics and Rare Diseases
- AI in cancer detection
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Esophageal Cancer Research and Treatment
- Cell Image Analysis Techniques
- Prenatal Screening and Diagnostics
- Aortic Disease and Treatment Approaches
- Pregnancy and Medication Impact
- Epilepsy research and treatment
- Voice and Speech Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Endometrial and Cervical Cancer Treatments
- Breast Lesions and Carcinomas
- Polyomavirus and related diseases
- Renal and related cancers
- Cardiac Arrest and Resuscitation
Seoul National University Hospital
2023-2024
Seoul National University
2010-2024
Oregon Health & Science University
2022-2023
University of Ulsan
2013-2021
Asan Medical Center
2013-2021
Ulsan College
2013-2021
Soonchunhyang University Hospital
2014-2016
Mayo Clinic in Florida
2014-2016
Soonchunhyang University
2015
Korean Red Cross
2009
A Western diet comprising high fat, carbohydrate, and low fiber content has been suggested to contribute an increased prevalence of colitis. To clarify the effect dietary cellulose (an insoluble fiber) on gut homeostasis, for 3 months mice were fed a high-cellulose (HCD) or low-cellulose (LCD) based AIN-93G formulation. Histologic evaluation showed crypt atrophy goblet cell depletion in colons LCD-fed mice. RNA-sequencing analysis higher expression genes associated with immune system...
Triple-negative breast cancer (TNBC) patients have a poor prognosis and few treatment options. Mouse models of TNBC are important for development new therapies, however, mouse represent the complexity TNBC. Here, we develop female murine model by mimicking two common mutations with high co-occurrence: amplification oncogene MYC deletion tumor suppressor PTEN. This Myc;Ptenfl develops heterogeneous triple-negative mammary tumors that display histological molecular features commonly found in...
Abstract The regulatory properties of pyruvate kinase M2 isoform (PKM2), the key glycolytic enzyme, influence altered energy metabolism including glycolysis in cancer. In this study, we found that PKM2 was highly expressed patients with ulcerative colitis or colorectal cancer (CRC). We then investigated effectiveness conditionally ablating Lgr5 + intestinal stem cells (ISC) using a mouse model colitis-associated CRC (AOM plus DSS). Tamoxifen-inducible Lgr5-driven deletion ISC (PKM2 ΔLgr5...
Objective Prognosis of myocardial infarction tends to be worse when serum C-reactive protein (CRP) level is high. miRNAs are also known involved in different pathogeneses heart diseases such as infarction. However, how CRP has not been fully elucidated. We hypothesized that changes the miRNA profile during ischemia-reperfusion injury (IRI) myocardium. To confirm this hypothesis, we performed global expression profiling myocardium using IRI and infusion rat model. Methods After ligation...
Although urothelial papilloma (UP) is an indolent papillary neoplasm that can mimic the morphology of low-grade carcinoma (PUC), there no immunomarker to differentiate reliably these two entities. In addition, molecular characteristics UP are not fully understood.
Imaging mass cytometry (IMC) is a powerful technique capable of detecting over 30 markers on single slide. It has been increasingly used for single-cell-based spatial phenotyping in wide range samples. However, it only acquires rectangle field view (FOV) with relatively small size and low image resolution, which hinders downstream analysis. Here, we reported highly practical dual-modality imaging method that combines high-resolution immunofluorescence (IF) high-dimensional IMC the same...
Chronic placental inflammation (CPI) has been implicated in the pathogenesis of diseases premature infants, whereas retinopathy prematurity (ROP) is a major complication primarily affecting preterm and very low-birth-weight (VLBW) infants. This study aims to investigate association between CPI ROP VLBW infants.We performed retrospective review clinical records infants born 2013 2016. Placental pathology findings including cases were analyzed using logistic regression infants' morbidities...
Vocal fold paralysis results from various etiologies and can induce voice changes, swallowing complications, issues with aspiration. is typically managed using injection laryngoplasty fat or synthetic polymers. Injection autologous has shown excellent biocompatibility. However, it several disadvantages such as unpredictable resorption rate, morbidities associated liposuction procedure which to be done in operating room under general anesthesia. Human adipose-derived extracellular matrix...
Introduction: Tissue-based sampling and diagnosis are defined as the extraction of information from certain limited spaces its diagnostic significance a object. Pathologists deal with issues related to tumor heterogeneity since analyzing single sample does not necessarily capture representative depiction cancer, tissue biopsy usually only presents small fraction tumor. Many multiplex imaging platforms (MTIs) make assumption that microarrays (TMAs) containing core samples 2-dimensional (2D)...
Esophageal adenocarcinoma (EAC) develops from a chronic inflammatory environment across four stages: intestinal metaplasia, known as Barrett’s esophagus, low- and high-grade dysplasia, adenocarcinoma. Although the genomic characteristics of this progression have been well defined via large-scale DNA sequencing, dynamics various immune cell subsets their spatial interactions in tumor microenvironment remain unclear. Here, we applied sequential multiplex immunohistochemistry (mIHC) platform...
Objective The molecular mechanisms of the degeneration aortic wall in abdominal aneurysm (AAA) are poorly understood. monomeric form C-reactive protein (mCRP) is deposited damaged cardiovascular organs and aggravates prognosis; however, it unknown whether mCRP degenerated aorta (AAA). We investigated AAA examined associated pathogenic signaling pathways. Methods Twenty-four cases were analyzed their histological features compared according to level serum CRP degree deposition. Proteomic...
Fetal lung interstitial tumor (FLIT), which is characterized by immature cells resembling the fetal parenchyma of 20 to 24 weeks gestation, a rare respiratory neoplasm. This study presents first reported FLIT in Korea. It also aims refine diagnostic method and increase accuracy prognostic assessment using next-generation sequencing check for anaplastic lymphoma receptor tyrosine kinase (anaplastic kinase) gene rearrangement. Although initial prognosis has been promising since its report...
ABSTRACT Background Abdominal aortic aneurysm (AAA) is a potentially lethal condition that often remains asymptomatic until it ruptures. Recent research suggests immune-inflammatory processes are associated with AAA development, yet the exact mechanisms remain unclear. Serum C-reactive protein (CRP) serves as prognostic marker for and various cardiovascular diseases. When CRP accumulates in damaged tissues, transforms into monomeric form, exacerbating tissue damage. Our previous study...
Preeclampsia (PE) is a hypertensive pregnancy disorder linked to placental dysfunction, often involving pathological lesions like acute atherosis, decidual vasculopathy, accelerated villous maturation, and fibrinoid deposition. However, there no gold standard for the diagnosis of PE this limits ability clinicians distinguish between non-PE pregnancies. Recent advances in computational pathology have provided opportunity automate analysis diagnosis, classification, prediction, prediction...