A5015833520- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Preterm Birth and Chorioamnionitis
- Ectopic Pregnancy Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- Fetal and Pediatric Neurological Disorders
- Maternal and fetal healthcare
- Pregnancy-related medical research
- Reproductive System and Pregnancy
- COVID-19 Impact on Reproduction
- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal Trauma and Injuries
- Hemodynamic Monitoring and Therapy
- Advanced ceramic materials synthesis
- Neonatal and fetal brain pathology
- Systemic Lupus Erythematosus Research
- Artificial Intelligence in Healthcare and Education
- Genomic variations and chromosomal abnormalities
- Cerebrovascular and Carotid Artery Diseases
Seoul National University
1998-2024
Korea University Medical Center
2023-2024
Korea University
2012-2024
Seoul National University Hospital
2017-2024
Seoul National University Bundang Hospital
2018-2024
New Generation University College
2021-2024
Korea Institute of Science and Technology
2003-2009
Abstract Background Previous studies showed that gestational diabetes mellitus (GDM) can be a risk factor for subsequent atherosclerotic cardiovascular disease. However, there is paucity of information regarding diverse outcomes in elderly women after GDM. In the current study, we examined whether with history GDM have an increased long-term overall outcomes. Methods Among UK participants, included 219,330 aged 40 to 69 years who reported at least one live birth. The new incidence was...
Pre-eclampsia (PE) is a pregnancy disorder that related to an enhanced immune response. Immune cell characteristics such as neutrophil or monocyte lymphocyte ratios (NLR, MLR) are known be kidney and liver dysfunction in hypertensive patients. Here, we aimed analyze the correlations between NLR, MLR platelet ratio (PLR) liver, renal coagulation functional parameters impacts of these profiles prognostic significance PE patients.Pre-delivery hematological biochemical 320 first-time pregnant...
Importance Massive transfusion is essential to prevent complications during uncontrolled intraoperative hemorrhage. As massive requires time for blood product preparation and additional medical personnel a team-based approach, early prediction of crucial appropriate management. Objective To evaluate real-time model surgery based on the incorporation preoperative data hemodynamic monitoring data. Design, Setting, Participants This prognostic study used sets from patients who underwent with...
Abstract Early identification of patients at risk developing preeclampsia (PE) would allow providers to tailor their prenatal management and adopt preventive strategies, such as low-dose aspirin. Nevertheless, no mid-trimester biomarkers have yet been proven useful for prediction PE. This study investigates the ability metabolomic in maternal plasma predict A case–control was conducted including 33 pregnant women with (gestational age [GA], 16–24 weeks) who subsequently developed PE 66...
In the era of coronavirus disease 2019 (COVID-19) pandemic, there is a paucity information regarding actual prevalence COVID-19 in pregnant women compared to non-pregnant women. The purpose this study was investigate infection and clinical outcome women.This nationwide cross-sectional South Korea between January 2020 February 2021 using claim database. primary women, secondary occurrence severe illness among infected patients. Severity classified into four categories according WHO ordinal...
Abstract Background To investigate the prognosis of remaining fetus in twin pregnancy after experiencing one fetal demise first trimester according to location demised fetus. Methods This was a retrospective study pregnancies with (14 weeks gestation) delivered between September 2004 and 2022. The population divided into two groups based on as determined by last recorded ultrasonography results: Group 1 included where presenting ( n = 36) 2 non-presenting 44). obstetric neonatal outcomes...
To determine the effects of cerclage on twin pregnancies.
Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of cardiovascular (CVD) in non-pregnant adults. Although the biological mechanisms underlying this association are not completely understood, metabolic factors, inflammation, and endothelial dysfunction likely all involved. The between NAFLD pregnancy-associated hypertension (HTN) has been systematically examined. aim study to assess risk HTN pregnant women with NAFLD.This secondary analysis a prospective healthy women....
To develop an early prediction model for gestational diabetes mellitus (GDM) using machine learning and to evaluate whether the inclusion of nonalcoholic fatty liver disease (NAFLD)-associated variables increases performance model.This prospective cohort study evaluated pregnant women NAFLD ultrasound at 10-14 weeks screened them GDM 24-28 gestation. The clinical before 14 were used models (setting 1, conventional risk factors; setting 2, addition new factors in recent guidelines; 3, routine...
Hypertension has been known to increase the risk of obstetric complications. Recently, American College Cardiology endorsed lower thresholds for hypertension as systolic blood pressure 130-139 mmHg or diastolic 80-89 mmHg. However, there is a paucity information regarding impact pre-pregnancy on pregnancy outcomes. We aimed evaluate effect maternal and neonatal complications.In this nationwide, population based study, pregnant women without history < 140/90 were enrolled. The primary outcome...
Abstract Patients with systemic lupus erythematosus (SLE) are at increased risk for adverse pregnancy outcome (APO). Accurate prediction of APO is critical to identify, counsel, and manage these high-risk patients. We undertook this study identify novel biomarkers in mid-trimester maternal plasma pregnant patients SLE APOs. The population consisted women whose was taken available metabolic signature: (1) normal (Group 1, n = 21); (2) 2, 12); (3) healthy controls 3, 10). Mid-trimester...
Clinical guidelines recommend several risk factors to identify women in early pregnancy at high of developing pregnancy-associated hypertension. However, these variables result low predictive accuracy. Here, we developed a prediction model for hypertension using graph-based semi-supervised learning. This is secondary analysis prospective study healthy pregnant women. To develop the model, compared performances across five machine learning methods (semi-supervised with both labeled and...
Pregnant women were excluded from vaccination against Coronavirus 2019 (COVID-19) until September 2021 in South Korea. Although for pregnant started October 2021, vaccine acceptance is yet unknown. This cross-sectional study aimed to investigate COVID-19 during pregnancy and influencing factors. An anonymous survey was distributed obstetrics departments all or postpartum women, the prenatal visit. The proportion of self-reported among 436 26.6%. Pregnancy-related independent factors maternal...
Objective . We aimed to determine whether elevated levels of various inflammatory and immune proteins in umbilical cord blood are associated with an increased risk newborn hearing screening (NHS) test failure preterm neonates. Methods This retrospective cohort study included 127 premature singleton infants who were born at ≤33.6 weeks. Umbilical plasma birth was assayed for interleukin (IL)-6, complement C3a C5a, matrix metalloproteinase (MMP)-9, macrophage colony-stimulating factor (M-CSF),...
Maladaptation to vascular, metabolic, and physiological changes during pregnancy can lead fetal growth disorders. Moreover, adverse outcomes further increase the risk of cardiovascular metabolic diseases in mothers. Delivering a large-for-gestational-age (LGA) baby may indicate pre-existing dysfunction, whereas delivering small-for-gestational-age (SGA) vascular dysfunction. This study aims assess hypertension (HTN) diabetes mellitus (DM) women with normal body mass index (BMI) scores who...
Expression quantitative trait loci (eQTL) analysis measures the contribution of genetic variation in gene expression on complex traits. Although this methodology has been used to examine regulation numerous human tissues, eQTL research solid tissues is relatively lacking. We conducted placentas collected from an East Asian population effort identify regulatory mechanisms tissue. Placentas (n = 102) were at time cesarean delivery. mRNA was extracted, sequenced with NGS, and compared matched...
Fetal growth restriction (FGR) is one of the leading causes perinatal morbidity and mortality. Many studies have reported an association between FGR fetal Doppler indices focusing on umbilical artery (UA), middle cerebral (MCA), ductus venosus (DV). The uteroplacental-fetal circulation which affects consists not only UA, MCA, DV, but also vein (UV), placenta uterus itself. Nevertheless, there a paucity large-scale cohort that assessed UV, uterine wall, placental thickness with outcomes in...
Background and AimsAdverse pregnancy outcomes (APOs) can worsen cardiometabolic risk factors in women, raising their likelihood of developing diseases at a young age after initial pregnancy. Nevertheless, there is limited data on the newly metabolic dysfunction-associated steatotic liver disease (MASLD) women who have had APOs. This study aimed to evaluate new-onset MASLD experiencing APOs.MethodsSingleton pregnant underwent national health screenings one year before delivery were included...
Adenomyosis impacts pregnancy outcomes, although there is a lack of consensus regarding the actual effects. It likely, however, that severity adenomyosis or ultrasound findings timing diagnosis can have different effects on adverse outcomes (APOs).
Lifestyle changes, such as those related to the COVID-19 pandemic, including alterations in physical activity and dietary habits, are known affect pregnancy outcomes. In particular, suboptimal intrauterine conditions during influence not only fetal growth but also infancy. However, research on impact of environmental changes caused by pandemic infants children their early years is lacking. To address this issue, study evaluated effect obesity infants. This retrospective cohort used data...