A5102792991- Electrospun Nanofibers in Biomedical Applications
- Gut microbiota and health
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Polymer Surface Interaction Studies
- Advanced Drug Delivery Systems
- Cleft Lip and Palate Research
- biodegradable polymer synthesis and properties
- Cancer, Hypoxia, and Metabolism
- Digestive system and related health
- Surface Modification and Superhydrophobicity
- Cardiac Structural Anomalies and Repair
- Advanced Polymer Synthesis and Characterization
- dental development and anomalies
- HER2/EGFR in Cancer Research
- Diet and metabolism studies
- Cancer Research and Treatments
- Advanced Sensor and Energy Harvesting Materials
- 3D Printing in Biomedical Research
- Clostridium difficile and Clostridium perfringens research
- Intracranial Aneurysms: Treatment and Complications
- Craniofacial Disorders and Treatments
- Estrogen and related hormone effects
- Surfactants and Colloidal Systems
- Cardiac Valve Diseases and Treatments
University of Pittsburgh
2020-2025
Larry Ellison Foundation
2021-2025
McGowan Institute for Regenerative Medicine
2020-2025
Rural Development Administration
2025
Mississippi State University
2024-2025
Korea Basic Science Institute
2008-2025
University of Ulsan
2018-2024
Asan Medical Center
2018-2024
Ulsan College
2018-2024
Ellison Institute of Technology
2021-2024
Mucin-degrading bacteria are densely populated in the intestinal epithelium; however, their interaction with stem cells (ISCs) and progeny have not been elucidated. To determine whether mucin-degrading play a role gut homeostasis, mice were treated Akkermansia muciniphila, specialized species that degrades mucin. Administration of A. muciniphila for 4 weeks accelerated proliferation Lgr5+ ISCs promoted differentiation Paneth goblet small intestine (SI). We found similar effects colon. The...
A Western diet comprising high fat, carbohydrate, and low fiber content has been suggested to contribute an increased prevalence of colitis. To clarify the effect dietary cellulose (an insoluble fiber) on gut homeostasis, for 3 months mice were fed a high-cellulose (HCD) or low-cellulose (LCD) based AIN-93G formulation. Histologic evaluation showed crypt atrophy goblet cell depletion in colons LCD-fed mice. RNA-sequencing analysis higher expression genes associated with immune system...
Abstract Shape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by a lack of non-invasive precise methods trigger control the shape recovery, especially for implanted in deep tissues. In this study, application image-guided high-intensity focused ultrasound (HIFU) heating tested. Magnetic resonance-guided HIFU triggered shape-recovery device...
The fusion of two distinct prominences into one continuous structure is common during development and typically requires integration epithelia subsequent removal that intervening epithelium. Using confocal live imaging, we directly observed the cellular processes underlying tissue fusion, using secondary palatal shelves as a model. We find convergence multi-layered epithelium single-layer an essential early step, driven by cell intercalation, concurrent to orthogonal displacement epithelial...
Development and processing of a biostable, anti-fouling zwitterionic polyurethane-urea based on PDMS for blood-contacting medical devices.
3D cell culture models have been developed to better mimic the physiological environments that exist in human diseases. As such, these are advantageous over traditional 2D cultures for screening drug compounds. However, practicalities of transitioning from treatment studies pose challenges with respect analysis methods. Patient-derived tumor organoids (PDTOs) possess unique features given their heterogeneity size, shape, and growth patterns. A detailed assessment length scale at which PDTOs...
Abstract Although functional interplay between intestinal microbiota and distant sites beyond the gut has been identified, influence of microbiota-derived metabolites on hematopoietic stem cells (HSCs) remains unclear. This study investigated role lactate in hematopoiesis using mice deficient G-protein-coupled receptor (Gpr) 81 (Gpr81 − /− ), an established receptor. We detected significant depletion total HSCs bone marrow (BM) Gpr81 −/− compared with heterogenic +/− ) a steady state....
Tissue-engineered vascular grafts (TEVGs) poised for regenerative applications are central to effective repair, with their efficacy being significantly influenced by scaffold architecture and the strategic distribution of bioactive molecules either embedded within or elicited from responsive tissues. Despite substantial advancements over recent decades, a thorough understanding critical cellular dynamics clinical success remains be fully elucidated. Graft failure, often ascribed...
In this study, anthocyanin glycosides from nine cultivars of highbush blueberries grown in Korea were characterized using UPLC-DAD-QToF/MS and UPLC-Qtrap-MS/MS. A total twenty-two derivatives identified, consisting mono-glycosides acetyl-glycosides attached to aglycones, such as cyanidin, peonidin, delphinidin, petunidin, malvidin. Among them, seven acetylated tentatively determined by comparing the related authentic standards previous reports presented mass fragmentation, which acetyl group...
Introduction In a model of right heart failure secondary to pulmonary artery banding (PAB), mechanical approach using an elastic, biodegradable epicardial patch with integrated extracellular matrix digest was evaluated for its potential inhibit disease progression. Methods Adult male syngeneic Lewis rats aged 6–7 weeks old were used. Biohybrid cardiac patches generated by co-processing poly(ester carbonate urethane) urea (PECUU) and the porcine matrix. Three after PAB, attached epicardium...
Cancer-associated fibroblasts (CAFs) play a key role in metabolic reprogramming and are well-established contributors to drug resistance colorectal cancer (CRC). To exploit this crosstalk, we integrated systems biology approach that identified targets data-driven method validated them experimentally. This process involved novel machine learning-based computationally screen, high-throughput manner, the effects of enzyme perturbations predicted by computational model CRC metabolism. reveals...
Akkermansia muciniphila, a promising candidate for next-generation probiotics, exhibits significant genomic diversity, classified into several distinct clades (AmI to AmIV). Notably, single clade tends predominate within individual hosts, with co-occurrence of different being rare. The mechanisms driving such clade-specific exclusion remain unclear. Here, we show that extracellular vesicles (EVs) derived from AmII inhibit the growth I (AmI), conferring competitive advantage AmII. Moreover,...
This article reviews stimuli-responsive and biostable polyurethanes (PUs) discusses biomedical applications of smart PUs with a particular focus on long-term implantable PU biomaterials such as generated artificial blood vessels, intervertebral discs (IVDs), intravaginal rings (IVRs). Recently, have been actively researched to enhance bioactivity, biocompatibility, reduce drug side effects. Although biodegradability is important in regenerative medicine, biostability plays key role for...
Immunotherapies are treatments that use a patient's immune system to combat disease. One important type of immunotherapy employed in cancer is the delivery monoclonal antibodies block growth receptors. In this manuscript, we develop methodology enables accurate and simple evaluation antibody-type drug using MALDI-MSI. To overcome mass-range limitation prevents detection large therapeutic antibodies, used situ reduction alkylation break disulfide bonds generate smaller fragments. These...