A5082738453- Adipokines, Inflammation, and Metabolic Diseases
- Metabolomics and Mass Spectrometry Studies
- Syntax, Semantics, Linguistic Variation
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Fatty Acid Research and Health
- Natural Language Processing Techniques
- Advanced Radiotherapy Techniques
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Food Quality and Safety Studies
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Language, Discourse, Communication Strategies
- Language, Metaphor, and Cognition
- Antioxidant Activity and Oxidative Stress
- Korean Urban and Social Studies
- Ion Channels and Receptors
- Nutrition, Genetics, and Disease
- Immune Cell Function and Interaction
- Education and Learning Interventions
- Linguistics and Discourse Analysis
Hannam University
2019-2025
Konkuk University
2017-2025
Duksung Women's University
2021-2024
Samsung (South Korea)
2005-2023
Food and Nutrition Service
2023
Keimyung University
2023
Sungkyunkwan University
2023
Dongguk University
2022-2023
Jaseng Hospital of Korean Medicine
2022-2023
NIHR Bristol Cardiovascular Biomedical Research Unit
2022
Triple-negative breast cancer (TNBC) is associated with a poor prognosis and metastatic growth. TNBC cells frequently undergo macroautophagy/autophagy, contributing to tumor progression chemotherapeutic resistance. ANXA2 (annexin A2), potential therapeutic target for TNBC, has been reported stimulate autophagy. In this study, we investigated the role of in autophagic processes cells. patients exhibited high levels ANXA2, which correlated outcomes. increased LC3B-II following bafilomycin A1...
The effect of consumption two probiotic strains, Lactobacillus curvatus HY7601 and plantarum KY1032, on weight loss, body adiposity lipoprotein-associated phospholipase A2 (Lp-PLA2) activities in overweight subjects was examined. After 12-week treatment, the group presented reductions (−0.65 ± 0.23 kg), fat percentage (−0.57 0.19%) mass (−616 161 g) measured using DEXA, L1 subcutaneous area (−2.68 1.31 cm2) CT, compared to baseline. exhibited greater oxidized low density lipoprotein (ox-LDL)...
This study aimed to evaluate the effects of dietary fiber from Chinese cabbage outer-leaf powder, which is a main by-product kimchi, on quality, texture properties, and sensory evaluation muffins. The kimchi powder (KBP, 36.2% fiber) was added at 1%-4% content, by replacing wheat flour (w/w basis). physico-chemical properties baked muffins were measured. height volume decreased with addition KBP. Increasing KBP content resulted in increased hardness reduced chewiness. No significant...
Abstract In the prospective Korean Cancer Prevention Study-II (KCPS-II), we investigated application of metabolomics to differentiate subjects with incident hepatocellular carcinoma (HCC group) from who remained free cancer (control during a mean follow-up period 7 years aim identifying valuable metabolic biomarkers for HCC. We used baseline serum samples 75 HCC and 134 age- gender-matched cancer-free subjects. Serum profiles associated incidence were via analysis. Compared control group,...
Probiotic supplementation increased the levels of C8:1, C14:1, C10, and C12:1 acylcarnitines, these increases were correlated with a decrease in body weight, fat percentage, mass L1 subcutaneous area.
ConspectusThe familiar pungent taste of spicy food, the refreshing mint, and many other physiological phenomena are mediated by transient receptor potential (TRP) ion channels. TRP channels a superfamily that sensitive to diverse chemical physical stimuli play roles in biology. In addition regulation, some family members also sense common stimuli, such as temperature or pressure. Since their discovery cloning 1990s 2000s, understanding molecular mechanisms governing channel function...
Prehypertension is a risk factor for atherosclerosis. We investigated alterations in plasma metabolites that are associated with prehypertension. A group of 53 individuals was identified who remained within the range prehypertension during repeated measurements 3-year period. This compared control normotensive subjects were matched age and gender. Metabolomic profiles analyzed UPLC-LTQ-Orbitrap mass spectrometry. The prehypertensive showed higher levels lysophosphatidylcholines (lysoPCs)...
Using metabolomics technique to analyze the response a dietary intervention generates valuable information concerning effects of prescribed diet on metabolic regulation. To determine whether low calorie (LCD)-induced weight reduction causes changes in plasma metabolites and characteristics. Overweight subjects consumed LCD (n = 47) or maintenance (control, n 50) randomized, controlled design study with 12-week clinical period. Plasma samples were analyzed using an UPLC-LTQ-Orbitrap MS. The...
High-sensitivity C-reactive protein (hs-CRP) is a marker of systemic inflammation and associated with developing dyslipidemia. However, the causality between hs-CRP dyslipidemia remains unresolved. This study aimed to investigate relationship concentrations explore potential causal link using Mendelian randomization (MR) analysis. A nested case–control was conducted 1174 participants, genotype data were analyzed Korean Chip. genome-wide association (GWAS) identified rs76400217 as suitable...
Secondary dyslipidemia, characterized by elevated blood cholesterol and triglycerides, arises from various underlying conditions. The identification appropriate handling of these causes is crucial for effective treatment. Major contributors include unhealthy diets, diseases impacting lipid metabolism, medication side effects. Prioritizing the correction secondary before initiating conventional lipid-lowering therapies essential. Subsequent profiles guide selection guideline-based interventions.
Axolotls ( Ambystoma mexicanum ) are known for their remarkable limb-regeneration abilities, which involve the formation of blastema, a specialized structure consisting progenitor cells contributed by all major tissues limb. Lateral plate mesoderm (LPM)-derived connective tissue (CT) dedifferentiate and play critical role in blastema subsequent limb regeneration. However, complexity blastema's cellular composition extent CT participation necessity have not been rigorously explored. To...
ABSTRACT An 11‐year‐old male castrated cat was presented for dyspnoea. Cardiomegaly and pulmonary oedema were identified radiographically. Echocardiography lesions of suspected aortic dissection consisting a false lumen filled with echogenic material at the level valve insufficiency. The developed pericardial effusion chylothorax three months after initial diagnosis. A computed tomography exam revealed wall defect allowing connection between true beak‐, spiral‐shaped compressing lumen, which...
Liver cirrhosis (LC) is the final usual outcome of liver damage induced by various chronic diseases. Because asymptomatic nature LC, it usually diagnosed at late and advanced stages, patients are easy to miss best timing for treatment. Thus, early detection LC needed. In prospective Korean Cancer Prevention Study-II (K-II), we aimed identify valuable biomarkers using metabolomics distinguish subjects with incident (LC group) from free (control during a mean 7-year follow-up period. Metabolic...
Pulse wave velocity (PWV) is thought to have different relationships with metabolic syndrome (MS) components, inflammatory markers, and oxidative stress, according age. However, age-specific determinants of PWV not yet been studied. We investigated age-dependent among MS stress.A total 4,318 subjects were divided into 4 groups: 19-34 y (n=687), 35-44 (n=1,413), 45-54 (n=1,384), 55-79 (n=834). brachial-ankle (baPWV), high-sensitivity C-reactive protein (hs-CRP), stress markers measured.There...
Abstract Background/Objectives The objective of this study was to evaluate the effect supplementation with a Jerusalem artichoke and fermented soybean powder mixture on blood glucose oxidative stress levels. Subjects/Methods This randomized, double-blinded, placebo-controlled conducted 60 subjects impaired fasting (IFG), tolerance (IGT), or newly diagnosed type 2 diabetes. were randomly assigned either group that ingested 40 g (19.45 each) daily received placebo for 12 weeks. Paired t -test...
We previously reported that human carboxylesterase 1 (CES1), a serine esterase containing unique N-linked glycosyl group at Asn79 (N79 CES1), is candidate serological marker of hepatocellular carcinoma (HCC). CES1 normally present low-to-undetectable levels in normal plasma, HCC tumors, and major liver cancer cell lines. To investigate the potential mechanism underlying suppression expression cells, we took advantage low detectability this tumors by overexpressing multiple lines, including...
Excess body weight is a major risk factor for type 2 diabetes (T2D) and associated metabolic complications, loss has been shown to improve glycemic control decrease morbidity mortality in T2D patients. Weight-loss strategies using dietary interventions produce significant diabetes-related disturbance. We have previously reported that the supplementation of low molecular chitosan oligosaccharide (GO2KA1) significantly inhibited blood glucose levels both animals humans. However, effect GO2KA1...
Abstract Background The apolipoprotein A5 gene ( APOA5 ) -1131 T > C polymorphism is associated with mild hypertriglyceridemia in type 2 diabetic subjects, and interacts dietary fat the determination of triglyceride concentrations. We examined whether a substitution whole grains legumes for refined rice high carbohydrate diet (about 65% energy derived from carbohydrate) may modify effect this variant on changes A-V (apoA-V) Methods genotyped individuals impaired fasting glucose (IFG) or...