A5101602191- Malaria Research and Control
- Mosquito-borne diseases and control
- Invertebrate Immune Response Mechanisms
- Synthesis and Catalytic Reactions
- Adipokines, Inflammation, and Metabolic Diseases
- Drug Transport and Resistance Mechanisms
- HIV/AIDS drug development and treatment
- Vector-borne infectious diseases
- Adipose Tissue and Metabolism
- vaccines and immunoinformatics approaches
- Metabolomics and Mass Spectrometry Studies
- Biochemical and Molecular Research
- Diet and metabolism studies
- HIV-related health complications and treatments
- Nutritional Studies and Diet
- Enzyme function and inhibition
- COVID-19 and Mental Health
- Complement system in diseases
- Molecular Biology Techniques and Applications
- Peroxisome Proliferator-Activated Receptors
- Viral Infections and Vectors
- Healthcare professionals’ stress and burnout
- Liver Disease and Transplantation
- Microplastics and Plastic Pollution
- Lysosomal Storage Disorders Research
Hannam University
2022-2025
Nanyang Technological University
2011-2023
Food and Nutrition Service
2023
Panyu District Central Hospital
2023
Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodium falciparum malaria parasites, allowing clonally variant expression during blood infection in humans. By assessing genome-wide heterochromatin protein 1 (HP1) occupancy, we present a comprehensive analysis landscapes across different species, strains, life cycle stages. Common targets epigenetic include fast-evolving multi-gene families encoding surface antigens small set conserved HP1-associated...
High-sensitivity C-reactive protein (hs-CRP) is a marker of systemic inflammation and associated with developing dyslipidemia. However, the causality between hs-CRP dyslipidemia remains unresolved. This study aimed to investigate relationship concentrations explore potential causal link using Mendelian randomization (MR) analysis. A nested case–control was conducted 1174 participants, genotype data were analyzed Korean Chip. genome-wide association (GWAS) identified rs76400217 as suitable...
This study aimed to assess the impact of dietary supplementation N-carbamoylglutamate (NCG) on nutrient digestibility, rumen fermentation, milk quality, oxidative stress, and metabolites in plasma feces Jersey cattle under high altitude with hypoxic condition. A total 14 healthy lactating dairy cows similar body conditions were selected randomly divided into 2 groups. The control group (CON group, N = 6 replicates) was fed a conventional complete diet, whereas experimental (NCG 8 received 20...
Drug resistance in Plasmodium falciparum remains a challenge for the malaria eradication programmes around world. With emergence of artemisinin resistance, efficacy partner drugs combination therapies (ACT) that include quinoline-based is becoming critical. So far only few markers have been identified from which two transmembrane transporters namely PfMDR1 (an ATP-binding cassette transporter) and PfCRT (a drug-metabolite experimentally verified. Another P. transporter, containing multidrug...
Development of the erythrocytic malaria parasite requires targeting proteins into multiple compartments located within and beyond confine. Beyond PEXEL/VTS pathway its characterized players, increasing amount evidence has highlighted existence exported using alternative export-signal(s)/pathway(s); hence, exportomes currently predicted are incomplete. The nature these which could have a prominent role in most Plasmodium species remains elusive. Using P. yoelii variant proteins, we identified...
The spleen and its response to parasite infection are important in eliminating parasites malaria. By comparing P. yoelii lines with different disease outcomes mice that had either intact spleens or their removed, we showed upon infection, the exhibits dramatic changes can affect clearance. itself directly impacts RBC deformability independently of genetics. data indicated biomechanical properties malaria parasite-infected RBCs result complex interaction between host parasite, serve as a...
Abstract Plasmodium associated virulence in the host is linked to extensive remodelling of erythrocyte by parasite proteins that form “remodellome”. However, without a common motif or structure available identify these proteins, little known about are destined reside periphery, host-cell cytoplasm and/or membrane. Here, subcellular fractionation erythrocytic P. yoelii at trophozoite and schizont stage along with label-free quantitative LC-MS/MS analysis whole proteome, revealed proteome 1335...
We aimed to use a genetic risk score (GRS) constructed with prediabetes and type 2 diabetes-related single nucleotide polymorphisms (SNPs) an oxidative stress (OSS) construct early-prediction model for diabetes (T2DM) incidence in Korean population. The study population included 549 T2DM patients 1036 normal subjects. GRS was using six T2DM-related SNPs, the OSS composed of three recognized biomarkers. Among nine showed significant associations T2DM. profoundly associated increased (OR =...
A key step for the survival of malaria parasite is release from and subsequent invasion erythrocytes by merozoite. Differences in efficiency these two linked processes have a direct impact on overall burden host thereby virulence. number proteases recently been shown to play important roles during both merozoite egress as well invasion. The rodent Plasmodium yoelii has extensively used investigate mechanisms virulence vivo proteins identified being contributors pathology. Here we utilized...
Invasion of the erythrocyte by merozoites malaria parasite is a complex process involving range receptor-ligand interactions. Two protein families termed Erythrocyte Binding Like (EBL) proteins and Reticulocyte Protein Homologues (RH) play an important role in host cell recognition merozoite. In rodent parasite, Plasmodium yoelii, 235 kDa rhoptry (Py235) are coded for multigene family members RH. P. yoelii Py235 as well single member EBL have been shown to be key mediators virulence enabling...
Novel sulphonamide antimalarials targeting parasitic <italic>N</italic>-myristoyl transferase.
Plasmodium parasites contribute to one of the highest global infectious disease burdens. To achieve this success, parasite has evolved a range specialized subcellular compartments extensively remodel host cell for its survival. The information fully understand these is likely hidden in so far poorly characterized species spatial proteome. address question, we determined steady-state location more than 12,000 proteins across five different by extensive fractionation erythrocytes infected...
Food packaging films play a vital role in preserving and protecting food. The focus has gradually shifted to safety sustainability the preparation of functional food materials. In this study, bisquaternary ammonium salt tannic acid (BQTA) was synthesized, bioplastics based on BQTA polyvinyl alcohol (PVA) were created for applications. impact antibacterial effect, antioxidant capacity, opacity, ultraviolet (UV) protective activity, mechanical strength, thermal stability, anti-fog resultant...
Object With the aim of enhancing prevention and regional control epidemics, mental health status medical personnel was analyzed before implementation closed-loop management during COVID-19 pandemic in hospital representative. Methods In accordance with directives from unified deployment national bureaus, following inclusion exclusion criteria, September 2021 to November 2022, all assigned a working environment by Guangzhou Panyu Central Hospital were enrolled as research subjects through...
Efforts to develop vaccines against malaria represent a major research target. The observations that 1) sterile protection can be obtained when the host is exposed live parasites and 2) immunity blood stage parasite principally mediated by protective antibodies suggest vaccine feasible. However, only small number of proteins have been investigated so far most Plasmodium proteome has yet explored. To date, few immunodominant antigens emerged for testing in clinical trials but no formulation...
Background/Aim: Elevation in liver enzymes and hepatic fat may indicate a higher susceptibility to cardiovascular disease (CVD). This research sought find anthropometric/biochemical variables significantly related the alanine aminotransferase (ALT) increase healthy populations. Methods: Nine hundred subjects were included 3-year prospective cohort study. The initial screening revealed that 538 found be nondiabetic (fasting glucose < 126 mg/dL) had normal ALT levels. Among them, 79...