A5100335623- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Acute Kidney Injury Research
- Chemotherapy-induced organ toxicity mitigation
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Inflammatory Biomarkers in Disease Prognosis
- Mercury impact and mitigation studies
- S100 Proteins and Annexins
- Glutathione Transferases and Polymorphisms
- Pharmacological Effects of Natural Compounds
- Caveolin-1 and cellular processes
- Biochemical Acid Research Studies
- Protease and Inhibitor Mechanisms
- Cancer, Lipids, and Metabolism
- Ion Transport and Channel Regulation
- Adipose Tissue and Metabolism
- Plant biochemistry and biosynthesis
- Circular RNAs in diseases
- Sex and Gender in Healthcare
- Heat shock proteins research
- Amino Acid Enzymes and Metabolism
- Autophagy in Disease and Therapy
- Electrolyte and hormonal disorders
- Chromatography in Natural Products
Duksung Women's University
2014-2024
Chungnam National University Hospital
2016
Dankook University
2016
Stanford University
2011
Triple-negative breast cancer (TNBC) is associated with a poor prognosis and metastatic growth. TNBC cells frequently undergo macroautophagy/autophagy, contributing to tumor progression chemotherapeutic resistance. ANXA2 (annexin A2), potential therapeutic target for TNBC, has been reported stimulate autophagy. In this study, we investigated the role of in autophagic processes cells. patients exhibited high levels ANXA2, which correlated outcomes. increased LC3B-II following bafilomycin A1...
Early prediction of metastatic breast cancer is important for improvement prognosis and survival rate. The present study aimed to identify secreted protein biomarkers detection invasive cancer. To this end, we performed a comparative proteomic analysis by combination 2DE MALDI-TOF MS conditioned media from H-Ras MCF10A human epithelial cells noninvasive N-Ras cells. We identified list 25 proteins that were strongly detected in focused on annexin II, which was shown be involved cell motility....
We investigated whether α-lipoic acid (α-LA), an antioxidant, attenuates the ischemia-reperfusion (I/R)-induced dysregulation of these transporters. Both renal pedicles male Sprague-Dawley rats were clamped for 40 min. α-LA (80 mg/kg) was administered intraperitoneally before and immediately after induction ischemia. After 2 days, expression aquaporins (AQPs), sodium transporters, nitric oxide synthases (NOS) determined in kidney by immunoblotting immunohistochemistry. The endothelin-1...
Ji Hyun Cheon, Sun Young Kim, Yeon Son, Ye Rim Kang, Hye An, Hoon Kwon, Ho Sub Song, Aree Moon, Byung Mu Lee, and Hyung Sik Kim. ToxicolRes 2016;32:47-56. https://doi.org/10.5487/TR.2016.32.1.047
The kidney is an important site of xenobiotic-induced toxicity. Because the traditional markers renal injury indicate only severe damage, new biomarkers are needed for a more sensitive and reliable evaluation This study was designed to identify in vitro noninvasive efficient assessment nephrotoxicity by using cisplatin as model nephrotoxic compounds. To this end, comparative proteomic analysis conditioned media from HK-2 human epithelial cells treated with performed. Here, we identified...
Sex-related incidence and outcomes were reported in various cancers, including colorectal cancer. 5-Fluorouracil (5-FU) is widely used as an essential chemotherapeutic agent for However, sex-based differences 5-FU toxicity have yet to be human cancer cell lines xenograft mouse models date. Here, we investigated, the first time, using colon lines, models, Korean patients' data. Female-derived exhibited greater 5-FU-induced cytotoxicity than male-derived lines. We established two models: one...
Abstract Ras mutations have been frequently observed in human cancer. Although there is a high degree of similarity between isomers, they display preferential coupling specific cancer types. The binding to the plasma membrane essential for its activation and biological functions. present study elucidated isoform‐specific interactions with their role Ras‐mediated activities. We investigated lipid raft protein flotillin‐1 (Flot‐1) activations Ras. found that Flot‐1 was co‐localized H‐Ras, but...
Cadmium (Cd2+) is a major environmental pollutant that induces cytotoxicity by heavy-metal accumulation. Prolonged Cd2+ exposure leads to cell damage oxidative stress mainly in the kidneys, critical organ for detoxification. To identify reliable on invasive protein biomarkers Cd2+-induced nephrotoxicity, we performed 2-dimensional gel electrophoresis/matrix-assisted laser desorption/ionization time of flight mass spectra and stable isotope labeling amino acids culture/liquid...
A new neolignan, named coixide (1), along with fifteen known compounds, (7R,8S)-3'-demethyl-dehydrodiconiferyl alcohol-3'-O-β-glucopyranoside (2), (7R,8)-3'-demethyl-9'-butoxy-dehydrodiconiferyl-3'-O-β-glucopyranoside (3),adenosine (4), 2-O-caffeoyl isocitricacid (5), pseudolaroside (6), 2-hydroxy-7-methoxy-(2H)-1,4-benzoxazin-3(4H)-one (7), 2-O-β-glucopyranosyl-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (8), 2-O-β-glucopyranosyl-4-hydroxy-7- methoxy-2H-1,4-benzoxazin-3(4H)-one (9),...
EGFR-tyrosine kinase inhibitor (TKI) has made dramatic changes in the concept and practice of lung cancer treatment. But there are still many limitations EGFR-TKIbecause that is effective only to patients who have drug sensitive EGFR mutations almost finally acquire resistance during EGFR-TKI To overcome EGFR-TKI, irreversible mutant specific EGFR-TKIs been developed. On other hands, combination treatment blocking oncogenic signals such as c-MET, AXL, or Src with tried. The hippo pathway...
Cadmium (Cd 2+ ) is a major environmental pollutant that induces cytotoxicity by heavy‐metal accumulation. Prolonged Cd exposure leads to cell damage oxidative stress mainly in the kidneys, critical organ for detoxification. In order identify reliable on invasive protein biomarkers ‐induced nephrotoxicity, we performed 2DE/MALDI‐TOF MS and SILAC/LC‐MS analyses using conditioned media (CM) of HK‐2 human kidney epithelial cells treated with CdCl 2 . Here, identified heat shock cognate 71 kDa...
C‐reactive protein (CRP) is an acute phase synthesized upon the inflammatory responses, associated with breast cancer. The process of tumor cell invasion and metastasis involves adherence cells to extracellular matrix via integrin as a receptor for molecules. present study investigated role CRP in adhesive phenotype underlying mechanisms. Here, we first showed that induces adhesion MCF10A human epithelial through activation α2 signaling. Expression was induced by which transcription factors...