A5009236947- Amyotrophic Lateral Sclerosis Research
- Ion-surface interactions and analysis
- Alzheimer's disease research and treatments
- Catalytic Processes in Materials Science
- Zeolite Catalysis and Synthesis
- Molecular Biology Techniques and Applications
- Prion Diseases and Protein Misfolding
- Gold and Silver Nanoparticles Synthesis and Applications
- Insect symbiosis and bacterial influences
- Mass Spectrometry Techniques and Applications
- Malaria Research and Control
- Advanced biosensing and bioanalysis techniques
- Fiber-reinforced polymer composites
- Catalysis and Hydrodesulfurization Studies
- Biosensors and Analytical Detection
- Membrane Separation and Gas Transport
- Genetic Neurodegenerative Diseases
- Mosquito-borne diseases and control
- Carbon Dioxide Capture Technologies
- Nanopore and Nanochannel Transport Studies
Korea Research Institute of Standards and Science
2018-2023
Korea University of Science and Technology
2018-2023
Indiana University School of Medicine
2023
Indiana University – Purdue University Indianapolis
2023
Inha University
2014
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging elucidates molecular distributions in tissue sections, providing useful information about the metabolic pathways linked to diseases. However, delocalization of analytes and inadequate adherence during sample preparation are among some unfortunate phenomena associated with this technique due their role reduction quality, reliability, spatial resolution ToF-SIMS images. For these reasons, requires a more rigorous method order...
The importance of multi-omic-based approaches to better understand diverse pathological mechanisms including neurodegenerative diseases has emerged. Spatial information can be great help in understanding how biomolecules interact pathologically and elucidating target biomarkers for developing therapeutics. While various analytical methods have been attempted imaging-based biomolecule analysis, a multi-omic approach imaging remains challenging due the different characteristics biomolecules....
Lipid alterations in the brain are well-documented disease and aging, but our understanding of their pathogenic implications remains incomplete.
Amyotrophic lateral sclerosis (ALS) is a degenerative disease caused by motor neuron damage in the central nervous system, and it difficult to diagnose early. Drosophila melanogaster widely used investigate mechanisms discover biomarkers because easy induce through genetic engineering. We performed matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) changes phospholipid distribution brain tissue of an ALS-induced model. Fly tissues several hundred micrometers or...
Biomolecule detection based on surface-enhanced Raman scattering (SERS) for application to biosensors and bio-imaging requires the fabrication of SERS nanoprobes that can generate strong signals as well surface modifications analyte-specific recognition binding. Such requirements lead disadvantages in terms reproducibility practicality, thus, it has been difficult apply biomolecule utilizing advantages phenomenon actual clinically relevant analysis. To achieve reproducible practical signal...
The Zika virus (ZIKV) is believed to cause birth defects, and no anti-ZIKV drugs have been approved by medical organizations date. Starting from antimicrobial lead compounds with a pyrazolo[3,4-d]pyridazine-7-one scaffold, we synthesized 16 derivatives screened their ability interfere ZIKV infection utilizing cell-based phenotypic assay. Of these, five showed significant inhibition of selective index value greater than 4.6. In particular, compound 9b the best activity selectivity 22.4...