A5063829388- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Plant Pathogens and Fungal Diseases
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Nanoparticles: synthesis and applications
- Plant Disease Resistance and Genetics
- Wheat and Barley Genetics and Pathology
- Malaria Research and Control
- Algal biology and biofuel production
- COVID-19 epidemiological studies
- Vector-borne infectious diseases
- Virus-based gene therapy research
- Microplastics and Plastic Pollution
- Bee Products Chemical Analysis
- Medicinal plant effects and applications
- Bioactive Natural Diterpenoids Research
- Bioactive natural compounds
- biodegradable polymer synthesis and properties
- SARS-CoV-2 detection and testing
- Insect symbiosis and bacterial influences
- Phytochemistry and Bioactivity Studies
- Tuberculosis Research and Epidemiology
National Institute Of Hygiene And Epidemiology
2011-2023
University of Da Nang
2019-2022
Nagasaki University
2020
Kobe University
2007-2009
Norovirus and rotavirus are the two most important causes of acute gastroenteritis in children worldwide. Both norovirus recognize human histo-blood group antigens (HBGAs), multiple binding patterns for HBGAs have been reported. To explore role host susceptibility to rotavirus, we conducted a cross-sectional study hospitalized with diarrhea northern Vietnam from September 2010 through 2012. Of 260 paired stool saliva samples, 158 (61%) were classified as HBGA secretors (Lea-b+), 31 (12%)...
Algae biorefinery is gaining much attention for the sustainable production of value-added products (e.g., biofuels, protein supplements etc.) globally. The current study aimed to investigate relationship between lipid and bacteria growth by an initial microalgae Chlorella vulgaris density culture in seafood wastewater effluent (SWE). According our results, C. concentration SWE influenced accumulation. ranged from 25–35 mg·L−1 which corresponds SWE’s chemical oxygen demand 365.67 ± 3.45...
Abstract Noroviruses (NoV) and sapoviruses (SaV) are recognized as important causes of acute gastroenteritis in children worldwide. In this study, the prevalence genetic variability NoV SaV were determined hospitalized <5 years age with Hanoi, Vietnam. A total 501 fecal specimens collected between November‐2007 October‐2008, that previously had been tested for rotavirus (RV), by realtime RT‐PCR. Positive samples genotyped conventional RT‐PCR followed sequencing. GII was detected 180 (36%)...
Common wheat cultivars are resistant to Magnaporthe grisea , a crabgrass ( Digitaria sanguinalis )-specific species of the blast fungus. To dissect genetic basis this “nonhost” type resistance, we need an exceptional cultivar that is susceptible M. grisea. A screening under various conditions revealed Triticum aestivum ‘Chinese Spring’ (CS) was isolate Dig41 when incubated at high temperature (26 °C) after inoculation. By contrast, T. ‘P168’, ‘Shin-chunaga’ (Sch), ‘Norin 4’ (N4), 26’ (N26),...
Between 2016 and 2019, 265 cases of Zika virus (ZIKV) infection were reported in Vietnam, predominantly southern Vietnam. In 2016, a case ZIKV-associated microcephaly was confirmed the Central Highlands, several members infant's family to be infected with ZIKV. The study aims determine level immunity ZIKV general population epidemic region.A total 879 serum samples collected from 801 participants between January 2017 July 2018, during after tested for anti-ZIKV immunoglobulin M (IgM) G...
Rotavirus (RV) is the most common cause of childhood diarrhea worldwide, and several vaccines have been successfully developed to reduce burden disease. However, lower vaccine immunogenicity efficacy in developing countries might be related virus-neutralizing activity breast milk. We examined possible differences milk antibody levels (total IgA antibody, RV-specific antibodies, RV-neutralizing antibodies) between healthy mothers living a rural area (n=145) an urban (n=147) Vietnam. Total...
A series of sixteen A-ring modified (2,3-indolo-, 2-benzylidene) oleanonic acid derivatives, holding some cyclic amines, linear polyamines and benzylaminocarboxamides at C28, has been synthesized screened for antiviral activity against influenza A/PuertoRico/8/34 (H1N1) Dengue virus serotypes DENV-1, -2, -3, -4. It was found that 28-homopiperazine 2 3-N-phthalyl 22 amides demonstrated high potency with selectivity index SI 27 (IC50 21 μM) 42 12 μM). Oleanonic aminoethylpiperazine amide 6...
Antibodies are critical responses to protect the host from dengue virus(DENV) infection. target DENV by two pathologic mechanisms: virus neutralization and infection enhancement. In patients, absence of neutralizing activity in presence FcγR implies that infection-enhancing hampers antibodies, which could potentially lead symptomatic presentations severe clinical outcomes. A total 100 pair serum samples adult healthy volunteers were obtained during season Ha Noi 2015 for evaluation activity....
Diseases caused by flaviviruses, including dengue fever and Japanese encephalitis, are major health problems in Vietnam. This cross-sectional study explored the feasibility of domestic dogs as sentinels to better understand risks mosquito-borne diseases Hanoi city. A total 475 serum samples from 221 households six districts were analyzed a competitive enzyme-linked immunosorbent assay (cELISA) for antibodies pr-E protein West Nile virus other flaviviruses due cross-reactivity. The overall...
Infectivity and neutralizing antibody titers of flavivirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are frequently measured using the conventional plaque assay. While assay is useful in determination infectivity, assays generally possess lower sensitivity time-consuming compared to nucleic acid amplification tests. In this study, a microcrystalline cellulose (MCC), Avicel, was evaluated as an alternative virus overlay medium, methylcellulose, for The performed dengue...
The Zika virus (ZIKV) is believed to cause birth defects, and no anti-ZIKV drugs have been approved by medical organizations date. Starting from antimicrobial lead compounds with a pyrazolo[3,4-d]pyridazine-7-one scaffold, we synthesized 16 derivatives screened their ability interfere ZIKV infection utilizing cell-based phenotypic assay. Of these, five showed significant inhibition of selective index value greater than 4.6. In particular, compound 9b the best activity selectivity 22.4...
Abstract Dengue fever pandemic caused by dengue virus has been claimed for many lives, however, no specific treatment is available. Prevention based on vector control posed to be the most effective measure so far. The application of chitosan stabilized silver nanoparticle (AgNPs) larvae and adult mosquitoes recently discovered, but their ability inhibit scarcely discussed. In this study, AgNPs have prepared tested against type 1. results showed that can 96.66% 98.33% 1 at 12.50 ppm 25.00...
The chemical study of the acidic extract Phaeanthus vietnamensis leaves led to isolation one new alkaloid, vietnamine A (1) and eight known alkaloids (R,S)-2N-norberbamunine (2), grisabine (3), 1S,1'R,O,O'-dimethylgrisabine (4), dauricine (5), neothalibrine (6), (7), xylopine (8), argentinine (9) by NMR MS comparing with data reported in literature. Compounds 1-9 were evaluated for inhibitory NO production RAW 264.7 macrophages, LPS-stimulated. 1-3 significantly inhibited on IC50 values 6.8...
Abstract Antidenge activity of the n ‐hexane, ethyl acetate and ‐butanol extracts from leaves Carica papaya against four dengue virus serotypes (DENV1‐4) were evaluated. As a result, ‐hexane extract showed best antiviral on all denge with PNRT 50 15.625 to 31.25 μg/ml. From extract, nine compounds including cycloartenol ( 1 ), cycloart‐23,25‐dien‐3 β ‐ol 2 cycloart‐25‐ene‐3 ,24 ‐diol 3 α 4 25‐hydroxycycloart‐23‐ene‐3‐one 5 ‐sitosterol 6 stigmasterol 7 nonacosan‐1‐ol 8 all‐ trans...
Abstract The ethanol extract from the leaves and twigs of Euphorbia cyathophora showed antiviral activity against four dengue virus serotypes (DENV1‐4), with PRNT 50 values 15.625‐62.5 μg/mL. Eight compounds including germanicol acetate ( 1 ), cymbopogone 2 1‐heptacosanol 3 ethyl α‐L‐arabinofuranoside 4 quercetin 5 3‐acetoxy‐5,7,3’,4’‐tetrahydroxyflavone 6 3‐acetoxy‐5,7,4 ’ ‐trihydroxyflavone 7 4’‐acetoxy‐3,5,7‐trihydroxyflavone 8 ) were isolated this extract. Compounds ‐ for first time ....
Abstract Background : Between 2016 and 2019, 265 cases of Zika virus (ZIKV) infection were reported in Vietnam, predominantly southern Vietnam. In 2016, a case ZIKV-associated microcephaly was confirmed the Central Highlands, several members infant’s family to be infected with ZIKV. The study aims determine level immunity ZIKV general population epidemic region. Methods: A total 879 serum samples collected from 801 participants between January 2017 July 2018, during after tested for...
Worldwide, medicinal plants have been known for economic and geographical advantages, thus possibly holding potentiality against dengue hemorrhagic fever. The methanol/water extracts from different parts of fourteen Vietnam-based plant species were subjected experimental screening on anti-dengue activity using baby hamster kidney cells (BHK21) plaque reduction neutralisation test (PRNT). Firstly, the tested serotype virus DENV-1. Seven out nineteen show PRNT50 values less than 31.25 μg/mL....
Abstract Nine compounds including ursolic acid ( 1 ), esculentic 2 2‐ O‐trans‐p ‐coumaroyl alphitolic 3 a mixture of 6S,7Z,9S )‐6,9‐dihydroxy‐7‐megastigmen‐3‐one 4 ) and (‐)‐boscialin 5 astragalin 6 tiliroside 7 2‐phyten‐1‐ol 8 4‐[3’‐(hydroxymethyl)oxiran‐2’‐yl]‐2,6‐dimethoxyphenol 9 were isolated from the twigs leaves Elaeagnus latifolia L. The elucidation above was supported by means modern spectroscopic methods (MS, NMR) comparison with reported data. It is first time 1‐9 have been . For...