A5039792303- Ion-surface interactions and analysis
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Molecular Junctions and Nanostructures
- Nanoparticle-Based Drug Delivery
- Nanopore and Nanochannel Transport Studies
- Advanced Nanomaterials in Catalysis
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Plasmonic and Surface Plasmon Research
- Analytical chemistry methods development
- Quantum Dots Synthesis And Properties
- 3D Printing in Biomedical Research
- Gas Sensing Nanomaterials and Sensors
- Force Microscopy Techniques and Applications
- Diamond and Carbon-based Materials Research
- Mass Spectrometry Techniques and Applications
- Graphene research and applications
- Connective tissue disorders research
- Cancer Cells and Metastasis
- Carbon Nanotubes in Composites
- Advanced Proteomics Techniques and Applications
- Protein Interaction Studies and Fluorescence Analysis
- Nanoplatforms for cancer theranostics
- Bone health and osteoporosis research
Korea Research Institute of Standards and Science
2014-2024
Korea University of Science and Technology
2011-2020
Korea Research Institute of Bioscience and Biotechnology
2020
Korea Advanced Institute of Science and Technology
2013-2017
Kootenay Association for Science & Technology
2015
Institute for Basic Science
2015
A potential method to tune reactivity In organic chemistry, reaction rates are often sensitive substituents that either donate or withdraw electron density from a reactive carbon center. Heo et al. now report when reactants tethered an electrode, the polarization effect of applied can exert analogous influence, essentially acting as tunable functional group. The authors demonstrate rate modulations in ester hydrolysis and arene cross-coupling, well two-step acid-to-amide conversion benefits...
For organ transplantation patients, the therapeutic drug monitoring (TDM) of immunosuppressive drugs is essential to prevent toxicity or rejection organ. Currently, TDM done by immunoassays liquid chromatography–tandem mass spectrometry (LC–MS/MS) methods; however, these methods lack specificity are expensive, require high levels skill, and offer limited sample throughput. Although matrix-assisted (MA) laser desorption ionization (LDI) (MS) can provide enhanced throughput cost-effectiveness,...
This study investigates the applicability of six transition metal dichalcogenides to efficient therapeutic drug monitoring ten antiepileptic drugs using laser desorption/ionization-mass spectrometry. We found that molybdenum ditelluride and tungsten are suitable for sensitive quantification drugs. The contribution tellurium enhanced efficiency desorption ionization was validated through theoretical calculations utilizing an integrated model incorporates transition-metal results our suggest...
Silica nanoparticles (SiO2 NPs) are commonly used in medical and pharmaceutical fields. Research into the cytotoxicity overall proteomic changes occurring during initial exposure to SiO2 NPs is limited. We investigated mechanism of toxicity human liver cells according time [0, 4, 10, 16 h (h)] through analysis using mass spectrometry. NP-induced various pathways HepG2 cells. Interestingly, when were exposed for 4 h, morphology remained intact, while expression proteins involved mRNA...
We have synthesized micrometer-sized Ag nanosheets via a facile, one-step, template-free electrochemical deposition in an ultra-dilute silver nitrate aqueous electrolyte. The nanosheet growth was revealed to occur three stages: (1) formation of polygonal nuclei on substrate, (2) {112}-faceted nanowire from the nuclei, and (3) anisotropic (111)-planar nanosheets, approximately 20 50 nm thickness 10 μm width, <112>-direction. vertical facet induced by strong interface anisotropy between...
We report an analysis method to identify conjugated ligands and their binding states on semiconductor nanocrystals based molecular information. Surface science techniques, such as time-of-flight secondary-ion mass spectrometry (ToF-SIMS) FT-IR spectroscopy, are adopted the micro-aggregated sampling method. Typical trioctylphosphine oxide-based synthesis methods of CdSe/ZnS quantum dots (QDs) have been criticized because peculiar effects impurities processes. Because ToF-SIMS technique...
Abstract Background Fibrosis plays an important role in both normal physiological and pathological phenomena as fibroblasts differentiate to myofibroblasts. The activation of is determined through interactions with the surrounding extracellular matrix (ECM). However, how this fibroblast-to-myofibroblast transition (FMT) regulated affected by elastin concentration a three-dimensional (3D) microenvironment has not been investigated. Methods We developed insoluble elastin-gradient 3D hydrogel...
Nanomaterials form a complex called “protein corona” by contacting with protein-containing biological fluids such as serum when they are exposed to physiological environments. The characteristics of these proteins, which one the substantial factors in cellular response, affected interactions between nanomaterials and systems. Many studies have investigated behaviors conducting experiments vitro vivo; however, origin materials used is rather inconsistent. This due fact that composition...
We report a low-cost, facile, and template-free electrochemical method of synthesizing three-dimensional (3D) hollow metallic nanostructures. The 3D nanoporous gold (3D-NPG) nanostructures were synthesized by galvanic replacement reaction (GRR) using the different reduction potentials silver gold; hemispherical nanoislands electrochemically deposited on cathodic substrates reverse-pulse potentiodynamic without templates then layer replicated shape islands during GRR process in an...
vascularized cancer models utilizing microfluidics have emerged as a promising tool for mechanism study and drug screening. However, the lack of consideration preparation methods cellular sources that are capable adequately replicating metastatic features circulating tumor cells contributed to low relevancy with
Abstract Chiral assemblies of plasmonic nanocrystals (NCs) are immense interest due to their distinctive physicochemical characteristics and promising potential in future optoelectronic applications. Despite recent advances the construction chiral NC assemblies, most approaches have led formation static irreversible structures with modest optical responses limited configurational tunability. Herein, a way prepare thermally reconfigurable helical assembly Au nanorods (AuNRs) strong...
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) measurement data and machine learning were used in this work to classify six different types of plastics. In order take into account the characteristics data, local maxima first examined a preprocessing step. Several methods then implemented create model that could successfully To visualize distribution, we applied dimensionality reduction method, namely, principal component analysis. Finally, distinguish between plastics, conducted...
The need for basement membrane extract (BME) with undefined constituents, such as Matrigel, intestinal stem cell (ISC) culture in traditional systems poses a significant barrier that must be overcome the development of clinical-grade, scalable, ready-to-use ISCs. Here, we propose functional polymer-based xenogeneic-free dish cells (XF-DISC), ensuring substantially prolonged maintenance ISCs derived from 3-dimensional human organoids (ISCs3D-hIO). XF-DISC enables remarkable expandability,...
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging elucidates molecular distributions in tissue sections, providing useful information about the metabolic pathways linked to diseases. However, delocalization of analytes and inadequate adherence during sample preparation are among some unfortunate phenomena associated with this technique due their role reduction quality, reliability, spatial resolution ToF-SIMS images. For these reasons, requires a more rigorous method order...
To achieve a reliable formation of surface-enhanced Raman scattering (SERS) sensor with evenly distributed hot spots on wafer scale substrate, we propose hybrid approach combining physical nanolithography for preparing Au nanodisks and chemical reduction growing them.
Since Ar-gas cluster ion beams (Ar-GCIBs) have been introduced into time-of-flight secondary mass spectrometry (ToF-SIMS), there various attempts to analyze organic materials and biomolecules that require low-damage analysis high sensitivity, because Ar-GCIBs allow soft ionization of large molecules such as peptides proteins due the low energy per atom. Here, authors adopted Ar-GCIB a primary beam detect including human insulin, ubiquitin, cytochrome C (molecular weights are 5808, 8564, 12...
Protein kinases are enzymes that important targets for drug discovery because of their involvement in regulating the essential cellular processes. For this reason, changes protein kinase activity induced by each candidate (the inhibitor case) need to be accurately determined. Here, an on-chip secondary ion mass spectrometry (SIMS) imaging technique peptides was developed determining and screening without a matrix. In our method, cysteine-tethered adsorbed onto gold surface produced relative...
In this paper, carbamate-based self-assembled monolayers (SAMs) of alkanethiolates on gold were suggested as a versatile platform for release amine-bearing molecules in response to the electrical signal. The designed SAMs underwent electrochemical oxidation surface with simultaneous amine molecules. synthesis thiol compounds was achieved by coupling isocyanate-containing hydroquinone. electroactive mixed 11-mercaptoundecanol [HS(CH(2))(11)OH] form monolayer, and cyclic votammetry used...
Chemical characterizations of biochemically functionalized single nanoparticles are necessary to optimize the nanoparticle surface functionality in recently advanced nanobiological applications but have not yet been fully explored because technical difficulties. Exploiting photoinduced force exerted on a light-illuminated nanoscale tip, mid-infrared hyperspectral images with 10 nm spatial resolution monolayer ligand-functionalized gold under ambient and environmental conditions presented. We...
We demonstrate a simple route to hybridize two different nanomaterials by using three-dimensional nanodishes that can serve as small plasmonic containers host guest nanoparticles. The were fabricated nanoimprint lithography and oblique-angle film deposition, the nanoparticles drop-cast onto nanodishes. Based on proposed method, colloidal Au assembled inside in form of labyrinth. These nanoparticle–nanodish hybrids excited strong surface plasmon resonance, verified numerical simulation local...
Precise graphene patterning is of critical importance for tailor-made and sophisticated two-dimensional nanoelectronic optical devices. However, graphene-based heterostructures have been grown by delicate multistep chemical vapor deposition methods, limiting preparation versatile heterostructures. Here, we report one-pot synthesis graphene/amorphous carbon (a-C) from a solid source polystyrene via selective photo-cross-linking process. Graphene successfully neat regions, while patterned...