A5042254280- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Lanthanide and Transition Metal Complexes
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Gallbladder and Bile Duct Disorders
- Cancer therapeutics and mechanisms
- Photodynamic Therapy Research Studies
- Advancements in Transdermal Drug Delivery
- Polymer Surface Interaction Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Advanced Nanomaterials in Catalysis
- MRI in cancer diagnosis
- Gastric Cancer Management and Outcomes
- Bioactive Compounds and Antitumor Agents
- Electrospun Nanofibers in Biomedical Applications
- Protein Degradation and Inhibitors
- Helicobacter pylori-related gastroenterology studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Histone Deacetylase Inhibitors Research
Inha University
2015-2024
Advanced Imaging Research (United States)
2023
The University of Texas Southwestern Medical Center
2023
Inha University Hospital
2023
Songdo Hospital
2010-2012
CHA University
2011
Seoul National University
2000-2008
Chong Kun Dang Bio (South Korea)
2001
Abstract The emerging tumor ferroptosis therapy confronts impediments of the microenvironment (TME) with weak intrinsic acidity, inadequate endogenous H 2 O , and a powerful intracellular redox balance system that eliminates toxic reactive oxygen species (ROS). Herein, strategy Fenton reaction cycloacceleration initiated by remodeling TME for magnetic resonance imaging (MRI)‐guided high‐performance tumors is proposed. synthesized nanocomplex exhibits enhanced accumulation at carbonic...
The detection of circulating tumor cells (CTCs) in the blood cancer patients is crucial for early diagnosis, prognosis, evaluation treatment effect chemotherapy drugs, and choice options. In this study, we propose new surface-enhanced Raman scattering (SERS) nanoparticles direct CTCs blood. Under optimized experimental conditions, our SERS exhibit satisfying performances rabbit A good linear relationship obtained between intensity concentration range 5–500 cells/mL (R2 = 0.9935), which...
All bound up: A poly(L-3,4-dihydroxyphenylalanine)-based ligand converts hydrophobic nanoparticles into hydrophilic and biocompatible species through several binding modes. Nanoparticles functionalized with this (see picture) are highly stable in various aqueous solutions. successful vivo MRI application using Fe3O4 confirmed their suitability for biomedical applications. Detailed facts of importance to specialist readers published as ”Supporting Information”. Such documents peer-reviewed,...
Abstract To surmount the major concerns of commercial small molecule Gd chelates and reported Gd‐based contrast agents (GBCAs) for magnetic resonance imaging (MRI), a new concept organogadolinium macrochelates (OGMCs) constructed from coordination between 3+ macromolecules is proposed. A library were screened coordination, two candidates [i.e., poly(acrylic acid) (PAA), poly(aspartic (PASP)] succeeded in OGMC formation. Under optimized synthesis conditions, both Gd‐PAA12 Gd‐PASP11 OGMCs are...
Non-alcoholic steatohepatitis (NASH) is characterized by hepatocellular injury and initial fibrosis severity has been suggested as an important prognostic factor of NASH. Silymarin was reported to improve carbon tetrachloride-induced liver reduce the activation hepatic stellate cells (HSC). We investigated whether silymarin could suppress HSCs in NASH induced methionine- choline-deficient (MCD) diet fed insulin-resistant rats. feeding MCD obese diabetic Otsuka Long-Evans Tokushima Fatty...
In this study, we fabricated albumin nanoparticles (ANP) using a solvent diffusion method and modified the surface of ANP with hematoporphyrin (HP) which has been used for cancer photodynamic therapy. Hematoporphyrin linked (HP-ANP) were further functionalized gamma-emitting nuclides (99mTc) scintigraphic imaging. The fabrication HP-ANP was optimized extensively to obtain particles within size range 100 200 nm. had enhanced accumulation in A549 CT-26 cell lines, activity against cells after...
<b>Background and study aim: </b>Metal stents for malignant biliary obstruction are susceptible to occlusion by tumor ingrowth or overgrowth. Therefore, we previously reported our use of a metal stent covered with paclitaxel-incorporated membrane giving an antitumor effect prevent from ingrowth. We have also developed new generation paclitaxel-eluting using containing Pluronic F-127 effective drug delivery. The aim this was investigate the safety efficacy delivery newly in tract. <b>Methods:...
Acne vulgaris is a common skin problem affecting nearly 90% of adolescents and its development associated with colonization Propionibacterium acnes ( P. ). Although antibiotics have commonly been used to treat acne, antibiotic resistance an emerging issue be solved. In this study, new way photodynamic acne therapy developed using lipase‐sensitive transfersome (DSPE‐PEG‐Pheo A (DPP) transfersome). For enhanced selectivity penetration efficiency, DPP transfersomes are prepared from...
Recently, nanozymes with peroxidase (POD)-like activity have shown great promise for ferroptosis-based tumor therapy, which are capable of transforming hydrogen peroxide (H2O2) to highly toxic hydroxyl radicals (•OH). However, the unsatisfactory therapeutic performance due insufficient endogenous H2O2 and acidity at sites has always been a conundrum. Herein, an ultrasmall gold (Au) @ ferrous sulfide (FeS) cascade nanozyme (AuNP@FeS) H2S-releasing ability constructed Au nanoparticle (AuNP)...