A5081852574- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Renal Transplantation Outcomes and Treatments
- HIV/AIDS drug development and treatment
- Pharmacogenetics and Drug Metabolism
- Pregnancy and Medication Impact
- Health Systems, Economic Evaluations, Quality of Life
- Acute Lymphoblastic Leukemia research
- Drug Solubulity and Delivery Systems
- Pharmacovigilance and Adverse Drug Reactions
- Computational Drug Discovery Methods
- Cardiac Health and Mental Health
- Cancer therapeutics and mechanisms
- Advanced Drug Delivery Systems
- Rheumatoid Arthritis Research and Therapies
- Diabetes Treatment and Management
- Diabetes Management and Research
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Pharmaceutical Practices and Patient Outcomes
- Cancer Genomics and Diagnostics
- Parathyroid Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Pharmaceutical Economics and Policy
- MicroRNA in disease regulation
Seoul National University
2015-2024
New Generation University College
2021
GTx (United States)
2018
Seoul National University Hospital
2017
Ulsan College
2010-2013
University of Ulsan
2010-2013
Asan Medical Center
2010-2013
St. John's University
2008-2011
National Cancer Institute
2005-2011
Center for Cancer Research
2005-2011
Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are expected to change the function of protein in which occur. We report that a synonymous SNP Multidrug Resistance 1 ( MDR 1) gene, part haplotype previously linked gene product P-glycoprotein (P-gp), nonetheless results P-gp with drug inhibitor interactions. Similar mRNA levels, but conformations, were found for wild-type polymorphic P-gp. hypothesize presence rare codon, marked by...
It has been reported that gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), the ability to modulate function of certain ATP-binding cassette (ABC) transporters and reverse ABC subfamily B member 1 (ABCB1; P-glycoprotein)- G 2 (ABCG2; breast cancer resistance protein/mitoxantrone protein)-mediated multidrug (MDR) in cells. However, it is unknown whether other EGFR TKIs have effects similar gefitinib. In present study, we investigated interaction another...
Sildenafil is a potent and selective inhibitor of the type 5 cGMP (cyclic guanosine 3',5'-monophosphate)-specific phosphodiesterase that used clinically to treat erectile dysfunction pulmonary arterial hypertension. Here, we report sildenafil has differential effects on cell surface ABC transporters such as ABCB1, ABCC1, ABCG2 modulate intracompartmental intracellular concentrations chemotherapeutic drugs. In ABCB1-overexpressing cells, nontoxic doses inhibited resistance increased effective...
Many machine learning techniques provide a simple prediction for drug-drug interactions (DDIs). However, systematically constructed database with pharmacokinetic (PK) DDI information does not exist, nor is there model that numerically predicts PK fold change (FC) it. Therefore, we propose (PK-DDIP) quantitative high accuracy, while constructing highly reliable PK-DDI database. Reliable of 3,627 DDIs was from 3,587 drugs using 38,711 Food and Drug Administration (FDA) drug labels. This...
Introduction: The human multidrug resistance gene ATP-binding cassette B1 (ABCB1) codes for P-glycoprotein (P-gp), an important membrane-bound efflux transporter known to confer anticancer drug as well affect the pharmacokinetics of many drugs and xenobiotics. A number single nucleotide polymorphisms (SNPs) have been identified throughout ABCB1 that may effect on P-gp expression levels function. Haplotype genotype analysis SNPs is becoming increasingly in identifying genetic variants...
Structural and biochemical studies of ATP-binding cassette (ABC) transporters suggest that an ATP-driven dimerization the nucleotide-binding domains (NBDs) is important reaction intermediate transport cycle. Moreover, asymmetric occlusion ATP at one two sites P-glycoprotein (Pgp) may follow formation symmetric dimer. It has also been postulated ADP drives dissociation In this study, we show E·S conformation Pgp (previously demonstrated in E556Q/E1201Q mutant Pgp) can be obtained with...
Individual differences in drug response can be caused by genetic and epigenetic variability disease determinants. Pharmacoepigenetics is a new field that studies the expression changes pharmacogenes without DNA sequences. Epigenetic control mechanisms are associated with methylation, histone modification, small noncoding RNA s, nucleosome remodeling. Researchers actively attempting to identify for controlling of enzymes transporters affecting metabolism disposition drugs. Current evidence...
Abstract As tacrolimus has a rather narrow therapeutic range and high individual variability in its pharmacokinetics, it is important to determine the cause of variation pharmacokinetics. The purpose this study was establish population pharmacokinetic–pharmacogenetic model identify covariates that affect pharmacokinetic parameters prevent fluctuations trough concentration during early period after transplantation. Data from 1501 concentrations 417 densely collected were compiled 122 patients...
Clinical trial globalization is a major trend for industry-sponsored clinical trials. There has been shift in sites towards emerging regions of Eastern Europe, Latin America, Asia, the Middle East, and Africa. Our study objectives were to evaluate current characteristics trials find out associated multiple factors which could explain its implications 2011–2013. The data elements "phase," "recruitment status," "type sponsor," "age groups," "design trial" from 30 countries extracted...
Each nucleotide-binding domain (NBD) of mammalian P-glycoproteins (Pgps) and human ATP-binding cassette (ABC) B subfamily members contains a tyrosine residue ∼25 residues upstream the Walker A domain. To assess role conserved Y401 Y1044 Pgp, we substituted these with F, W, C, or either singly together. The mutant proteins were expressed in Vaccinia virus-based transient expression system as well baculovirus-infected HighFive insect cells. Y401F, Y401W, Y1044F, Y1044W, Y401F/Y1004F mutants...
Through extensive screening of marine sponge compounds, the authors have found that sipholenol A, a sipholane triterpene isolated from Red Sea sponge, Callyspongia siphonella , potently reversed multidrug resistance (MDR) in cancer cells overexpressed P‐glycoprotein (P‐gp). In experiments, A potentiated cytotoxicity several P‐gp substrate anticancer drugs, including colchicine, vinblastine, and paclitaxel, but not non‐P‐gp cisplatin, significantly MDR KB‐C2 KB‐V1 concentration‐dependent...
Abstract Background and Aim: A Western‐style diet (WD) is known to play an important role in inflammatory bowel disease colon carcinogenesis. The purpose of this study was understand the macrophages WD‐induced colitis associated with Methods: Male BALB/c mice were fed a WD or control (CD) for 4 weeks exposed azoxymethane (AOM) followed by 2% dextran sulfate sodium (DSS) 7 days. Results: increased susceptibility DSS‐induced inflammation accelerated infiltration macrophages. incidence...
The objective of the study was to investigate pharmacokinetic drug-drug interactions between tacrolimus (TAC) and mycophenolate mofetil (MMF) in healthy Korean male volunteers. Seventeen volunteers participated a three-period, single-dose, fixed sequence study. They sequentially received MMF, TAC, combination. Concentrations mycophenolic acid (MPA), its metabolites MPA 7-O-glucuronide acyl glucuronide were measured. variants CYP3A4, CYP3A5, SLCO1B1, SLCO1B3, ABCC2, UGT1A9, UGT2B7 genotyped....
Abstract The recommended antiviral drugs available for the treatment and prevention of influenza are neuraminidase inhibitors (NAIs). aim this study was to evaluate age-related clinical manifestations adverse events (AEs) related NAIs. FAERS WebMD data were downloaded. NAIs selected analysis oseltamivir, peramivir, zanamivir, laninamivir. Disproportionality analyzed using proportional reporting ratio (PRR), odds (ROR), information component (IC) methods. In total, 16729 AEs from 4598...