A5009559740- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sphingolipid Metabolism and Signaling
- Endoplasmic Reticulum Stress and Disease
- Renal Diseases and Glomerulopathies
- Natural Antidiabetic Agents Studies
- Prostate Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Chronic Kidney Disease and Diabetes
- Polysaccharides and Plant Cell Walls
- Calcium signaling and nucleotide metabolism
- Enzyme Catalysis and Immobilization
- Cancer Mechanisms and Therapy
- Attention Deficit Hyperactivity Disorder
- Autism Spectrum Disorder Research
- Fungal and yeast genetics research
- Cancer Cells and Metastasis
- Birth, Development, and Health
- Dialysis and Renal Disease Management
- Chromatin Remodeling and Cancer
- Melanoma and MAPK Pathways
Nemours Children's Clinic
2024
Washington University in St. Louis
2018-2024
Mayo Clinic in Florida
2024
Nemours Children’s Clinic
2024
Jacksonville College
2024
WinnMed
2024
Can Tho University
2021-2023
Mayo Clinic
2022
Viet Nam University Of Traditional Medicine
2021-2022
University of California, Davis
2000-2020
Diabetic nephropathy is a major global health problem. Progression to renal failure common; however, the mechanisms are unknown. Experimental models suggest role for macrophages. Therefore, macrophage accumulation and its relationship subsequent clinical course were studied.A retrospective study of baseline histology over at least 5 years involving 20 consecutive patients with histological diagnosis diabetic was performed. The between in biopsy tissue (KP-1/anti-CD68+ cells), measures known...
Resistance to androgen receptor (AR) antagonists is a significant problem in the treatment of castration-resistant prostate cancers (CRPC). Identification mechanisms by which CRPCs evade deprivation therapies (ADT) critical develop novel therapeutics. We uncovered that rely on BRD4-HOXB13 epigenetic reprogramming for androgen-independent cell proliferation. Mechanistically, BRD4, member BET bromodomain family, epigenetically promotes HOXB13 expression. Consistently, genetic disruption or...
Abstract Purpose: Androgen receptor (AR) antagonism is exacerbated by HOXB13 in castration-resistant prostate cancers (CRPC). However, it unclear when and how primes CRPCs for AR antagonism. By mass-spectrometry analysis of CRPC extract, we uncovered a novel lysine 13 (K13) acetylation mediated CBP/p300. To determine whether acetylated K13-HOXB13 clinical biomarker development, characterized its role cancer biology. Experimental Design: We identified tumor-specific acK13-HOXB13 signal...
Abstract HOXB13, a homeodomain transcription factor, is linked to recurrence following radical prostatectomy. While HOXB13 regulates Androgen Receptor (AR) functions in context dependent manner, its critical effectors prostate cancer (PC) metastasis remain largely unknown. To identify transcriptional targets metastatic PCs, we performed integrative bioinformatics analysis of differentially expressed genes (DEGs) the proximity human tumor-specific AR binding sites. Unsupervised Principal...
We prove several identities on homogeneous groups that imply the Hardy and Rellich inequalities for Bessel pairs. These equalities give a straightforward understanding of some as well absence nontrivial optimizers existence/nonexistence “virtual”extremizers.
The regulator of G-protein signaling 5 (RGS5) belongs to a family GTPase activators that terminate cascades initiated by extracellular mediators and G-protein-coupled receptors. RGS5 has an interesting dual biological role. One functional role is as pericyte biomarker influencing the switch angiogenesis during malignant progression. Its other promote apoptosis in hypoxic environments. We set out clarify extent which expression regulates tumor progression—whether it plays pathogenic or...
The World Health Organization has designated Zika virus (ZIKV) as a dangerous, mosquito-borne flaviviral pathogen that was recently found to be responsible for dramatically increased number of microcephaly cases and other congenital abnormalities in fetuses newborns. There is neither vaccine prevent nor drug treat ZIKA infections, at the present time. Berberine (BBR) promising approved by FDA against dengue virus, BBR derivatives are great interest antiviral development. In this study, we...
Werner syndrome is a hereditary disease characterized by cancer predisposition, genetic instability, and the premature appearance of features associated with normal aging. At molecular level this has been related to mutations in helicase, member RecQ family DNA helicases which are required maintain genomic stability cells. Here we show yeast two‐hybrid screen that helicase can directly interact regulatory subunit (RIβ) cAMP protein kinase A (PKA). We confirm interaction occurs vivo....
Abstract Lung squamous cell carcinoma (LUSC) is a devastating disease, accounting for ~30% of all lung cancer diagnoses and ~40,000 deaths annually in the United States alone. LUSC patients suffer from high prevalence relapse dismal 5-year survival only ~24%. The lack animal models that reflect salient features human disease to assess safety efficacy drugs, explore underlying molecular mechanisms tumor biology, major impediment patients. We have identified concomitant 3q26 copy number gain...
Abstract Lung adenocarcinoma (LUAD), the most prevalent subtype of lung cancer, can arise from two different cell populations: alveolar type 2 (AT2) cells and bronchiolar club cells. By utilizing genomic data cancer genome atlas program, human LUAD lines, well-characterized LSL-KrasG12D/Trp53-/- (KP) mouse model, we demonstrated that tumors arising are much more aggressive follow a trajectory tumorigenesis when compared to those AT2 Intriguingly, our strongly suggest expression signaling...
Advanced localized prostate cancers (PC) recur despite chemotherapy, radiotherapy and/or androgen deprivation therapy. We recently reported HOXB13 lysine (K)13 acetylation as a gain-of-function modification that regulates interaction with the SWI/SNF chromatin remodeling complex and is critical for anti-androgen resistance. However, whether acetylated promotes PC cell survival following treatment genotoxic agents not known. Herein, we show K13-acetylated induced rapidly in cells response to...
Cardiovascular diseases (CVDs) are notably prevalent among patients with obstructive sleep apnea (OSA), posing unique challenges in predicting CVD progression due to the intricate interactions of comorbidities. Traditional models typically lack necessary dynamic and longitudinal scope accurately forecast trajectories OSA patients. This study introduces a novel multi-level phenotypic model analyze interplay these conditions over time, utilizing data from Wisconsin Sleep Cohort, which includes...
Abstract Autotaxin (ATX) is an enzyme discovered in the conditioned medium of cultured melanoma cells and identified as a protein that strongly stimulates motility. This unique ectonucleotide pyrophosphatase phosphodiesterase facilitates removal choline headgroup from lysophosphatidylcholine (LPC) to yield lysophosphatidic acid (LPA), which potent lipid stimulator tumorigenesis. Thus, ATX has received renewed attention because it prominent role malignant progression represents promising area...
Supplementary Figure from Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer