A5103195892- Autophagy in Disease and Therapy
- Heavy Metal Exposure and Toxicity
- Gout, Hyperuricemia, Uric Acid
- Genetic diversity and population structure
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
- Pancreatic and Hepatic Oncology Research
- Inflammasome and immune disorders
- Fish Ecology and Management Studies
- Cancer, Lipids, and Metabolism
- Viral gastroenteritis research and epidemiology
- Liver physiology and pathology
- Natural Products and Biological Research
- Veterinary medicine and infectious diseases
- Herbal Medicine Research Studies
- Phagocytosis and Immune Regulation
- Spondyloarthritis Studies and Treatments
- Lipid metabolism and biosynthesis
- Hepatitis B Virus Studies
- NF-κB Signaling Pathways
- Reproductive Biology and Fertility
- Skin and Cellular Biology Research
- Curcumin's Biomedical Applications
- PARP inhibition in cancer therapy
Shandong University of Traditional Chinese Medicine
2025
Chinese Academy of Fishery Sciences
2017-2025
Ministry of Agriculture and Rural Affairs
2023-2025
Wuhan University
2025
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2021-2023
Fujian Medical University
2017-2022
North Carolina Central University
2020-2022
First Affiliated Hospital of Fujian Medical University
2022
Huazhong Agricultural University
2017-2022
Center for Excellence in Molecular Cell Science
2018-2021
Spilanthes acmella (Paracress), a common spice, has been administered as traditional folk medicine for years to cure toothaches, stammering, and stomatitis. Previous studies have demonstrated its diuretic, antibacterial, anti-inflammatory activities. However, the active compounds contributing effect seldom addressed. This study isolates compound, spilanthol, by bioactivity-guided approach indicates significant activity on lipopolysaccharide-activated murine macrophage model, RAW 264.7. The...
Background and Aims Studies of the identity pathophysiology fibrogenic HSCs have been hampered by a lack genetic tools that permit specific inducible fate‐mapping these cells in vivo . Here, single‐cell RNA sequencing nonparenchymal from mouse liver, we identified transcription factor 21 ( Tcf21 ) as unique marker restricted its expression to quiescent HSCs. Approach Results Tracing + ‐CreER (Cre‐Estrogen Receptor fusion protein under control gene promoter) targeted ~10% all HSCs, most which...
Abstract Tumor necrosis factor-α-induced protein 8 (TNFAIP8) expression has been linked to tumor progression in various cancer types, but the detailed mechanisms of TNFAIP8 are not fully elucidated. Here we define role early events associated with development hepatocellular carcinoma (HCC). Increased levels HCC cells enhanced cell survival by blocking apoptosis, rendering more resistant anticancer drugs, sorafenib and regorafenib. also induced autophagy steatosis liver cells. Consistent...
Cadmium (Cd) is an environmental pollutant that increases hepatotoxicity and the risk of liver diseases. In current study, we investigated effect a physiologically relevant, low concentration Cd on regulation cancer cell proliferation, steatosis, fibrogenic/oncogenic signaling. Exposure to concentrations increased endogenous reactive oxygen species (ROS) production enhanced proliferation in human bipotent progenitor line HepaRG hepatocellular carcinoma (HCC) lines. Acute exposure Jagged-1...
Sleepy cod (Oxyeleotris lineolata) is native to Australia and now an economically valuable fish cultured in China Southern Asian countries. Its growth rate exhibits as sexually dimorphic, with males generally growing more rapidly attaining a larger body size compared females. Thus, the effective development of sex control breeding can significantly contribute increased yields output value. Nevertheless, due lack genomic transcriptomic data, molecular mechanisms underlying determination...
Land use monitoring by satellite remote sensing can improve the capacity of ecosystem resources management. The source, bandwidth, computing speed, data storage and cost constrain development application in field. A novel deep learning classification method based on feature augmentation (CNNs-FA) is developed this paper, which offers a robust avenue to realize regional low-cost high-precision land monitoring. Twenty-two spectral indices are integrated augment vegetation, soil water features,...
Although aspirin (acetylsalicylic acid) is commonly used to prevent ischaemic events in patients with coronary artery disease, many fail respond treatment. Dietary fish oil (FO), containing ω3 polyunsaturated fatty acids (PUFAs), has anti-inflammatory and cardio-protective properties, such as lowering cholesterol modulating platelet activity. The objective of the present study was investigate potential additional effects FO on activity vascular response injury.Femoral arterial remodelling...
Hepatitis B virus (HBV) reactivation with a hepatitis flare is common complication in lymphoma patients treated immunotherapy and/or chemotherapy. Anti-HBV prophylaxis suggested for non-Hodgkin (NHL) undergoing rituximab therapy, even those resolved HBV infection. Since anti-HBV infection not covered by national health insurance Taiwan, proportion of these receive no prophylaxis. In addition, late has emerged as new issue recent reports, and consensus been reached the optimal duration...
It has been proved that lactate-4.25% dialysate could result in peritoneal fibrosis by inducing alternative activation of macrophages our previous study, but the mechanism high glucose-induced not elucidated. This study was, therefore, to investigate glucose stimuli.In this Raw264.7 (murine macrophage cell line) cells were cultured and stimulated 4.25% medium, mannitol medium was used as osmotic pressure control. Cells harvested at 0 h, 4 8 12 h examine expression Arg-1, CD206, p-Akt. After...
To determine the distribution of Norovirus (NoV) genotypes in natural river water Thailand, we conducted a genome analysis using next‐generation sequencer. Twenty‐five samples were collected at five different sites Khlong Klon River suburbs Bangkok between August 2013 and December 2014. The partial NoV was detected 15 25 (60·0%). Seven these (46·7%) contained multiple GII genotypes: GII.4, GII.6, GII.17. Our data showed that GII.17 had already emerged as minor population, it became major...
Abstract Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is a member of the TIPE/TNFAIP8 family which regulates tumor growth and survival. Our goal to delineate detailed oncogenic role TNFAIP8 in skin cancer development progression. Here we demonstrated that higher expression associated with basal cell carcinoma (BCC), squamous (SCC), melanoma patient tissues. Induction by TNFα or ectopic SCC lines resulted increased growth/proliferation. Conversely, silencing decreased survival/cell...
It was to investigate the diagnostic value of keratin 7 (KRT7) in malignant metastasis epithelial ovarian cancer and benign tumors. From January 2018 2019, 30 fresh tissues tumors, borderline metastatic were collected The First Affiliated Hospital Fujian Medical University, normal as control group. Federation gynecology obstetrics (FIGO) staging criteria: 25 cases stage I, 26 II, 16 III, 23 IV. relative expression KRT7 detected by real-time fluorescence quantitative PCR, relationship between...
In this study, the complete mitochondrial (mt) genome of Cichlao cellaris was determined. The mt has a length 16,526 bp and encodes 13 protein-coding genes (PCGs), 22 transfer RNA genes, two ribosomal one AT-rich non-coding region (D-loop). gene arrangement similar to those typical fishes. total base composition 25.1% T, 30.8% C, 29.3% A, 14.8% G. Of PCGs, 12 start with an ATG codon, except COX1 is GTG. And among these seven (ND1, COX1, ATP8, ND4L, ND5, ND6, Cytb) used TAA or TAG as...