A5102849581- Viral Infectious Diseases and Gene Expression in Insects
- Insect Resistance and Genetics
- NF-κB Signaling Pathways
- RNA Research and Splicing
- Bone Metabolism and Diseases
- Autophagy in Disease and Therapy
- CRISPR and Genetic Engineering
- Plant Physiology and Cultivation Studies
- Cytokine Signaling Pathways and Interactions
- Genomics, phytochemicals, and oxidative stress
- Sirtuins and Resveratrol in Medicine
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Lipid metabolism and disorders
- Ubiquitin and proteasome pathways
- Steroid Chemistry and Biochemistry
- Seaweed-derived Bioactive Compounds
- PARP inhibition in cancer therapy
- Traditional Chinese Medicine Analysis
- Adenosine and Purinergic Signaling
- Enzyme-mediated dye degradation
- Chromium effects and bioremediation
- Gastrointestinal Tumor Research and Treatment
- ATP Synthase and ATPases Research
- Metabolism, Diabetes, and Cancer
Dalian Medical University
2024-2025
Shanghai Ninth People's Hospital
2025
Shanghai Jiao Tong University
2009-2025
Shihezi University
2019-2024
Xinjiang Production and Construction Corps
2022-2023
National Center of Biomedical Analysis
2006-2022
Peking University
2022
First People's Hospital of Yunnan Province
2020-2021
Center for Excellence in Molecular Cell Science
2019
Xinjiang University
2013-2019
Abstract The mammalian nicotinamide‐adenine dinucleotide (NAD)‐dependent deacetylase Sirt1 impacts different processes involved in the maintenance of brain integrity and pathogenic pathways associated with several neurodegenerative disorders, including Alzheimer's disease. Here we used human transgenic mice to demonstrate that neuron‐specific overexpression promoted neurite outgrowth improved cell viability under normal nutrient‐limiting conditions primary culture systems...
DNA damage response (DDR) acts as a tumorigenesis barrier, and any defects in the DDR machinery may lead to cancer. SOX4 expression is elevated many types of tumors; however, its role still largely unknown. Here, we show that SOX4, new sensor, required for activation p53 tumor suppressor damage. Notably, interacts with stabilizes protein by blocking Mdm2-mediated ubiquitination degradation. Furthermore, enhances acetylation interacting p300/CBP facilitating p300/CBP/p53 complex formation. In...
RANKL and SCLEROSTIN antibodies have provided a strong effective choice for treating osteoporosis in the past years, which suggested novel molecular target identification therapeutic strategies development are important treatment of osteoporosis. The effect verapamil, drug previously used cardiovascular diseases, on diabetes was due to inhibition TXNIP expression, has also been reported as mice Whether verapamil-inhibited expression is related how it works level worthy be explored....
Abstract Koolen-de Vries syndrome (KdVS) is a rare disorder caused by haploinsufficiency of KAT8 regulatory NSL complex subunit 1 ( KANSL1 ), which characterized intellectual disability, heart failure, hypotonia, and congenital malformations. To date, no effective treatment has been found for KdVS, largely due to its unknown pathogenesis. Using siRNA screening, we identified as an essential gene autophagy. Mechanistic study shows that modulates autophagosome-lysosome fusion cargo degradation...
Bone homeostasis between osteoclast bone resorption and osteoblastic formation is tightly regulated by a series of factors such as the receptor activator nuclear factor-κB ligand (RANKL). Denosumab that neutralizes RANKL effective widely applied in treatment postmenopausal osteoporosis. However, participated RANKL-related remodeling process primary secondary osteoporosis are less known. Revealing novel transcriptional regulatory mechanism great significance for After differential expression...
Abstract RNA interference (RNAi) induced through double-stranded (dsRNA) has been used widely to study gene function in insects. In this paper we demonstrate the efficacy of RNAi cotton bollworm, Helicoverpa armigera . Using CYP6B6 as target gene, which is expressed fat baby and midgut lepidopteran pest H. , constructed vector dsRNA CYP6B6. Northern blot analysis showed that Escherichia coli (HT115) was gene. The results also expression level protein larvae fed with by E. were significantly...
Activating mutations in KIT have been associated with gastrointestinal stromal tumors (GISTs). The tyrosine kinase inhibitor imatinib mesylate has revolutionized the treatment of GISTs. Unfortunately, primary or acquired resistance to does occur GISTs and forms a major problem. Although sunitinib malate, multi-kinase inhibitor, shown effectiveness against imatinib-resistant GISTs, recent studies indicated that some harboring secondary activation loop were also resistant sunitinib. Therefore,...
Exogenous double-stranded RNA (dsRNA) is a potent initiator of gene silencing in diverse organisms. In the present study, we used genetically engineered bacterial strain HT115 to express dsRNA corresponding CYP6B6 Helicoverpa armigera Hübner, which an economical way produce large quantities dsRNA. After investigated effect pH, saline solution, hemolymph plasma, and time on stability from bacteria vitro, tested exogenous transcription translation larval CYP6B6, growth, development,...
Cotton bollworm (Helicoverpa armigera) is a polyphagous pest that causes agricultural and commercial losses in many parts of the world. These are compounded by insecticide abuse, which leads to resistance as well environmental food pollution. RNA interference (RNAi) powerful tool used gene functional research RNAi-based control. In this study, arginine kinase (AK) cotton was selected target gene, it plays critical role cellular energy metabolism invertebrates. Two fragments H. armigera AK...
Vascular calcification (VC) is a common pathophysiological process of chronic kidney disease (CKD). Sirtuin 3 (Sirt3), major NAD+-dependent protein deacetylase predominantly in mitochondria, involved the pathogenesis VC. We previously reported that intermedin (IMD) could protect against In this study, we investigated whether IMD attenuates VC by Sirt3-mediated inhibition mitochondrial oxidative stress. A rat with CKD model was induced 5/6 nephrectomy plus vitamin D3. smooth muscle cell...
In insect, the cytochrome P450 plays a pivotal role in detoxification to toxic allelochemicals. Helicoverpa armigera can tolerate and survive 2-tridecanone treatment owing CYP6B6 responsive expression, which is controlled by some regulatory DNA sequences transcription regulators. Therefore, region regulators of are responsible for cotton bollworm. this study, we used yeast one-hybrid screen two potential from H. that respond plant secondary toxicant 2-tridecanone, were named Prey1 Prey2,...
Cancer is the world's biggest health problem and cancer-induced mortality happened all over planet after heart disease. The present study was to scrutinize anti-leukemia effect of diosmin against Dalton Ascitic Lymphoma (DAL) induced leukemia in mice. DAL cell used for induction solid tumor. Body weight, life spans, tumor volume mean survival time estimated. Antioxidant, biochemical pro-inflammatory cytokines were Diosmin showed viability at dose dependent manner both lines. mice decreased...
Abstract Alcohol dehydrogenase 5 (ADH5) is a member of medium‐chain dehydrogenase/reductase family and takes part in cellular formaldehyde S‐nitrosoglutathione metabolic network. 2‐tridecanone (2‐TD) toxic compound many Solanaceae crops to defend against variety herbivory insects. In the broader context insect development pest control strategies, this study investigates how new ADH5 from Helicoverpa armigera ( Ha ADH5) regulates expression CYP6B6 , gene involved molting metamorphosis,...