A5000057773- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Mesenchymal stem cell research
- Maternal and fetal healthcare
- Neonatal Respiratory Health Research
- Bariatric Surgery and Outcomes
- Congenital Diaphragmatic Hernia Studies
- Preterm Birth and Chorioamnionitis
- Endometrial and Cervical Cancer Treatments
- Tracheal and airway disorders
- Congenital Anomalies and Fetal Surgery
- Urinary and Genital Oncology Studies
- Ectopic Pregnancy Diagnosis and Management
- Neonatal and fetal brain pathology
- COVID-19 Impact on Reproduction
- Prenatal Screening and Diagnostics
- Pregnancy-related medical research
- Urological Disorders and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cancer Risks and Factors
- Tissue Engineering and Regenerative Medicine
- Maternal and Perinatal Health Interventions
- Congenital Heart Disease Studies
- Reproductive System and Pregnancy
Kitasato University
2022-2025
Keio University
2011-2023
Keio University Hospital
2018-2023
Saitama Municipal Hospital
2012-2015
City Hospital
2012
Cardiotocography records fetal heart rates and their temporal relationship to uterine contractions. To identify high risk fetuses, obstetricians inspect cardiotocograms (CTGs) by eye. Therefore, CTG traces are often interpreted differently among obstetricians, resulting in inappropriate interventions. However, few studies have focused on quantitative nonbiased algorithms for evaluation. In this study, we propose a newly constructed deep neural network model (CTG-net) detect compromised...
Objective To investigate pregnancy outcomes in women after abdominal radical trachelectomy (RT) for early-stage cervical cancer. Methods The patients’ background, fertility, and were reviewed a total of 61 pregnancies 48 172 who underwent RT at Keio University Hospital between September 2002 December 2013. Results There 5 with stage IA1, 2 IA2, 41 IB1. Histological types as follows: squamous cell carcinoma (n = 36), adenocarcinoma 10), adenosquamous 2). rate attempting to conceive was 44%...
Abstract Despite the poor prognosis associated with myelomeningocele (MMC), options for prenatal treatments are still limited. Recently, fetal cellular therapy has become a new option treating birth defects, although therapeutic effects and mechanisms such remain unclear. The use of human amniotic fluid stem cells (hAFSCs) is ideal respect to immunoreactivity cell propagation. diagnosis MMC during early stages pregnancy could allow ex vivo proliferation modulation autologous hAFSCs in utero...
Hypoglycemia is one of the most significant problems in neonates born to mothers with gestational diabetes (GDM). This study aimed identify novel predictors hypoglycemia GDM. A total 443 term singleton infants from diagnosed GDM and cared for at Keio University Hospital between January 2013 December 2019 were included this study. Neonatal was defined as less than 47 mg/dL 1 or 2 4 h after birth, according previous studies. Among full-term GDM, 200 developed (45%). Gestational weight gain...
Objective To investigate the association between mid‐trimester residual cervical length ( CL ) and risk of preterm birth in pregnancies after abdominal radical trachelectomy RT ). Design Retrospective cohort study. Setting University hospital. Population A total 33 deliveries 22 weeks’ gestation 30 women who underwent including prophylactic cerclage perinatal care January 2002 May 2016. Methods The (the distance external os) gestational age at delivery was investigated. Receiver–operating...
Here, we report a case of congenital peribronchial myofibroblastic tumor (CPMT). A 34-year-old primigravida was referred to our hospital at 31 gestation weeks because suspected pulmonary airway malformation (CPAM). Fetal ultrasonography showed mass measuring 4.6 × 4.0 3.9 cm with mixed high and low echogenicity in the left lung, which associated microvascular blood flow tumor. magnetic resonance imaging (MRI) revealed low-intensity lobe lung lesion on T2-weighted image. These findings...
Abstract Background Despite recent advances in neonatal care, sepsis remains a leading cause of mortality neonates. Mesenchymal stem cells derived from various tissues, such as bone marrow, umbilical cord, and adipose tissue, have beneficial effects on adult sepsis. Although human amniotic fluid (hAFSCs) mesenchymal cell properties, the efficacy hAFSCs is yet to be elucidated. This study aimed investigate therapeutic potential using rat model lipopolysaccharide (LPS)-induced Methods were...
Introduction Genome-wide methylation analyses of gestational diabetes mellitus (GDM) diagnosed after 24 weeks (late GDM (L-GDM)) using cord blood have been reported. However, epigenetic changes in neonates born to mothers with before (early (E-GDM)) not We investigated DNA E-GDM samples. Research design and methods analysis was performed an Illumina EPIC array compare rates 754 255 autosomal sites samples from term 162 (E-GDM: n=84, L-GDM: n=78) 60 normal glucose tolerance (normal OGTT)...
Gestational diabetes (GDM) and type 2 (T2DM) share part of pathomechanism several T2DM susceptibility genes are demonstrated to be associated with GDM. No information on the genetics GDM, however, was available in Japanese women. In this study, risk variants (45 single nucleotide polymorphisms [SNPs] from 36 genes) identified previous studies were genotyped using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry a cohort 171 women GDM 128 normal glucose tolerance...
Gestational diabetes (GDM) is one of the most common perinatal complications. As pregnant women have to consume 75 g glucose during an oral tolerance test (OGTT) in order diagnose GDM, they stay longer hospitals. Since its outbreak, COVID-19 has spread all over world. To prevent infection, patients must minimize hospital visits, avoid spending long periods time at hospital, and limit face-to-face contact with healthcare practitioners. a result, Japanese Society Diabetes Pregnancy published...
Though recommended for pregnant women at risk of preterm birth to improve perinatal outcomes, antenatal corticosteroid (ACS) treatment can cause maternal hyperglycemia, especially in cases glucose intolerance. A standardized protocol preventing hyperglycemia during ACS remains be established. We herein retrospectively investigated the time-dependent changes insulin dose required glycemic control gestational diabetes (GDM). Twelve singleton with GDM who received 12 mg betamethasone...
The detection of epigenetic changes associated with neonatal hypoglycaemia may reveal the pathophysiology and predict onset future diseases in offspring. We hypothesized that reflects utero environment maternal gestational diabetes mellitus. aim this study was to identify hypoglycaemia. association between DNA methylation using Infinium HumanMethylation EPIC BeadChip plasma glucose (PG) level at 1 h after birth 128 offspring born term mothers well-controlled mellitus investigated by robust...
Introduction: The average birth weight in Japan has gradually decreased and the number of low infant increased over last 30 years. Japanese pregnant women are characterized with lower prevalence obesity than those other developed countries, maternal underweight before pregnancy is independently associated weight. However, association between inadequate gestational gain (GWG) risk small for age (SGA) uncomplicated not been fully understood. This study aimed to examine effect GWG on SGA...
Objective Fetal fractional limb volume has been proposed as a useful measure for quantifying fetal soft tissue development. The aim of this study was to investigate the growth arm (AVol) and thigh (TVol) fetuses with maternal gestational diabetes (GDM) compared those normal glucose tolerance (NGT). We hypothesised would be larger in GDM group than NGT late gestation. Design Exploratory observational study. Setting Saitama Municipal Hospital. Sample A total 165 (125 40 GDM) singleton Japanese...