A5083894273- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gastrointestinal motility and disorders
- Cardiac Fibrosis and Remodeling
- Congenital Diaphragmatic Hernia Studies
- Genetic Syndromes and Imprinting
- Alkaline Phosphatase Research Studies
- Bariatric Surgery and Outcomes
- Glycosylation and Glycoproteins Research
- Congenital Heart Disease Studies
- Abdominal vascular conditions and treatments
- Intestinal and Peritoneal Adhesions
- Gastroesophageal reflux and treatments
- Spinal Dysraphism and Malformations
- Single-cell and spatial transcriptomics
- Preterm Birth and Chorioamnionitis
- Bone health and osteoporosis research
- Pharmacological Receptor Mechanisms and Effects
- Cardiac Imaging and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Complement system in diseases
- Vasculitis and related conditions
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Dietary Effects on Health
Saitama Municipal Hospital
2015-2024
Keio University Hospital
2022-2024
Keio University
2017-2023
City Hospital
2018-2021
Saiseikai Utsunomiya hospital
2018
Saiseikai Central Hospital
2017
West Los Angeles College
1998
Gunma University
1995
Abstract Images obtained from single-photon emission computed tomography for myocardial perfusion imaging (MPI SPECT) contain noises and artifacts, making cardiovascular disease diagnosis difficult. We developed a deep learning-based support system using MPI SPECT images. Single-center datasets of images (n = 5443) were labeled as healthy or coronary artery based on reports. Three axes four-dimensional datasets, resting, stress conditions three-dimensional reconstruction data, reconstructed,...
Failure of the right ventricle plays a critical role in any type heart failure. However, mechanism remains unclear, and there is no specific therapy. Here, we show that predominantly expresses alternative complement pathway-related genes, including Cfd C3aR1. Complement 3 (C3)-knockout attenuates ventricular dysfunction fibrosis mouse model C3a produced from C3 by convertase complex, which includes essential component factor D (Cfd). Cfd-knockout mice also attenuation Moreover, plasma...
Objective To investigate the association between mid‐trimester residual cervical length ( CL ) and risk of preterm birth in pregnancies after abdominal radical trachelectomy RT ). Design Retrospective cohort study. Setting University hospital. Population A total 33 deliveries 22 weeks’ gestation 30 women who underwent including prophylactic cerclage perinatal care January 2002 May 2016. Methods The (the distance external os) gestational age at delivery was investigated. Receiver–operating...
Objective Fetal fractional limb volume has been proposed as a useful measure for quantifying fetal soft tissue development. The aim of this study was to investigate the growth arm (AVol) and thigh (TVol) fetuses with maternal gestational diabetes (GDM) compared those normal glucose tolerance (NGT). We hypothesised would be larger in GDM group than NGT late gestation. Design Exploratory observational study. Setting Saitama Municipal Hospital. Sample A total 165 (125 40 GDM) singleton Japanese...
A number of data on gestational diabetes mellitus (GDM) in singleton pregnancy is available, however, little known about the glycemic characteristics twin with GDM.The aim this study was to compare severity dysglycemia between and pregnancies GDM (T-GDM S-GDM).We retrospectively analyzed defined by Japan Diabetes Society criteria (T-GDM, n = 20; S-GDM, 451) our hospital.During period, women underwent self-monitoring blood glucose measurements as well dietary management.Insulin treatment...
Hypophosphatasia (HPP) is an autosomal recessive metabolic disorder with impaired bone mineralization due to mutations in the ALPL gene. The genotype‐phenotype correlation of this has been widely described. Here, we present two affected siblings, whose fetal phenotypes were discordant. A 31‐year‐old Japanese woman, G0P0, was referred our institution because micromelia. After obstetric counseling, pregnancy terminated at 21 weeks’ gestation. Post‐mortem radiographs demonstrated severely...
Fetal fractional limb volume is a useful measure for predicting birth weight and newborn adiposity; however, normal growth curve has been reported solely in the United States. As of neonates Japan significantly lower than that US, fetal likely to be smaller Japanese population. This study aimed define arm (AVol) thigh (TVol) Ultrasound scans 453 AVol TVol pairs were obtained; each percentile at gestational age was calculated. The measured week also converted z-scores based on previous...
Prader–Willi Syndrome (PWS) is a complex, multi-system disorder, which was first described in 1956 (Prader et al. 1956). PWS caused by the absence of expression paternally active genes on...
Cells of uterine endometrial cancer cell line SNG-II were classified into two groups according to their reactivity with anti-uterine monoclonal antibody (MSN-1), whose recognition antigen is mainly the Lewis(b) antigens; those that strongly reacted MSN-1 (SNG-S group) and weakly it (SNG-W group). The SNG-S showed a higher activity 1-->4-fucosyltransferase than SNG-W. expression was stronger in Therefore, cancer-specific fucosylated carbohydrate could be controlled by alpha-fucosyltransferase...
Summary Endothelial cells (ECs) maintain cardiac homeostasis and EC dysfunction causes heart failure progression. Moreover, pathological changes occur via interactions between multiple cells, including ECs. Here, we conducted single-cell RNA-seq analysis of non-cardiomyocytes in mouse hearts during progression to elucidate the ECs fibroblasts (FBs) mediated by cell-cell interactions. We show that capillary arterial exhibit mesenchymal gene expression with progression, indicating...
Objectives: To evaluate the effect of type 1 diabetes (T1DM) compensation in pregnancy on fetal growth.Methods: Sixty-seven pregnant women with T1DM were prospectively followed throughout pregnancy.Serial ultrasound biometry, including biparietal diameter, head circumference, abdominal and femur length, was performed at 14 to 18 weeks, 24 28 weeks 34-38 weeks.Estimated weight computed according Hadlock et al.Individual growth velocity determined as difference centiles between two successive...
Objective: We report laparoscopic surgery for an infertile woman with a peritoneal inclusion cyst (PIC) surrounding the entire ovary and hydrosalpinx of opposite side, which were considered to have been caused by endometriosis chlamydia infection.