A5079281815- Assisted Reproductive Technology and Twin Pregnancy
- Metabolomics and Mass Spectrometry Studies
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Prenatal Screening and Diagnostics
- Pharmaceutical Practices and Patient Outcomes
- Neuropeptides and Animal Physiology
- Pregnancy and preeclampsia studies
- Obesity, Physical Activity, Diet
- Blood Pressure and Hypertension Studies
- Fetal and Pediatric Neurological Disorders
- Medication Adherence and Compliance
- Nutrition and Health in Aging
- Sleep and related disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neurogenesis and neuroplasticity mechanisms
- Pediatric Urology and Nephrology Studies
- Sleep and Wakefulness Research
- Health Systems, Economic Evaluations, Quality of Life
- Pain Management and Opioid Use
- COVID-19 and healthcare impacts
- Diet and metabolism studies
- Heat shock proteins research
- Maternal and fetal healthcare
- Receptor Mechanisms and Signaling
Keio University
1997-2025
Seirei Hamamatsu General Hospital
2005-2017
Setsunan University
2014-2017
Showa University
1993-2017
Chiba Cancer Center
2014
Hiroshima University
2003-2005
Rakuno Gakuen University
2004
Osaka University
2003
Kagawa University
1999-2001
Gunma University
2000
<h3>Objective</h3> Phenytoin (PHT) is routinely used for seizure prophylaxis in patients with brain tumours during and after craniotomy, despite incomplete evidence. We performed a prospective, randomised study to investigate the significance of prophylactic use levetiracetam (LEV), comparison PHT, supratentorial perioperative period. <h3>Methods</h3> Patients were receive LEV, 500 mg/body every 12 h until postoperative day 7, or 15–18 mg/kg fosphenytoin followed by 125 mg PHT 7. The primary...
This study aimed to examine the association between sleep duration and quality sarcopenia, assessed by factors such as low muscle mass (LMM), strength (LMS), physical performance (LPP) among older community-dwellers in Japan. In this cross-sectional study, a total of 2,069 (men, 902; women, 1,167) participants aged 65 80 years were included. Sarcopenia each function defined using definitions Asian Working Groups 2019. Sleep was stratified into three categories: short (<6 h), normal (6-8 long...
Aims: Nonalcoholic fatty liver disease (NAFLD) is known to be associated with atherosclerosis. This study focused on upstream changes in the process by which NAFLD leads The aimed confirm association between and cardio-ankle vascular index (CAVI), an indicator of subclinical atherosclerosis, explore metabolites involved both assessing 94 plasma polar metabolites.
Abstract Background Nosocomial spread of coronavirus disease 2019 (COVID-19) causes clusters infection among high-risk individuals. Controlling this is critical to reducing COVID-19 morbidity and mortality. We describe an outbreak in Keio University Hospital, Japan, its control propose effective measures. Methods When was suspected, immediate isolation thorough polymerase chain reaction (PCR) testing patients health care workers (HCWs) using in-house system, together with extensive contact...
Background: The application of metabolomics-based profiles in environmental epidemiological studies is a promising approach to refine the process health risk assessment. We aimed identify potential urine and plasma for detection relatively low-level cadmium (Cd) exposure large population-based studies.
Introduction: The association between alcohol consumption and cardiovascular events differs according to the presence or absence of risk factors such as hypertension dyslipidemia. However, effect renal function on that is unclear in general populations. Hypothesis: Renal status modifies disease (CVD) risk. Methods: We followed 10,515 Japanese community dwellers (4,824 men 5,691 women) without a history CVD, who participated baseline survey population-based cohort study conducted 2012 2015,...
Branched-chain amino acids (BCAAs) play a key role in energy homeostasis.We aimed to investigate the association between plasma BCAA levels and dyslipidemia Japanese population without diabetes mellitus.This cross-sectional study included 4952 participants mellitus, enrolled Tsuruoka Metabolomic Cohort Study. Plasma were measured by capillary electrophoresis-mass spectrometry. Correlations lipid profiles evaluated sex-stratified multiple linear regression analyses, after adjusting for...
Using duplex ultrasonography (US), the authors showed compression of extracranial vertebral artery (ECVA) during neck rotation in 5.0% 1,108 patients. Age (per 10-year increase, OR 0.80, 95% CI 0.67 to 0.96), vessel diameters 0.5-mm diameter 0.63, 0.51 0.79), and symptoms upon (OR 4.01, 1.35 11.9) were associated with compression. In one case, SPECT revealed decreased cerebral perfusion hindbrain rotation. ECVA US is useful identifying compression, especially patients on
Background: Although self-reported questionnaires are widely employed in epidemiologic studies, their validity has not been sufficiently assessed. The aim of this study was to evaluate the a questionnaire on medication use by comparison with health insurance claims and identify individual determinants discordance Tsuruoka Metabolomics Cohort Study.
The Tsuruoka Metabolomics Cohort Study (TMCS) is an ongoing population-based cohort study being conducted in the rural area of Yamagata Prefecture, Japan. This aimed to enhance precision prevention multi-factorial, complex diseases, including non-communicable and aging-associated by improving risk stratification prediction measures. At baseline, 11,002 participants aged 35–74 years were recruited City, Japan, between 2012 2015, with follow-up survey. Participants underwent various...
Pituitary adenylate cyclase-activating polypeptide (PACAP, encoded by adcyap1) plays an important role in ectodermal development. However, the involvement of PACAP development other germ layers is still unclear. This study assessed expression a PACAP-specific receptor (PAC1) gene and protein mouse bone marrow (BM). Cells strongly expressing PAC1(+) were large size, had oval nuclei, merged with CD34(+) cells, suggesting that former hematopoietic progenitor cells (HPCs). Compared wild-type...
Sweat secretion is the major function of eccrine sweat glands; when this process disturbed (paridrosis), serious skin problems can arise. To elucidate causes paridrosis, an improved understanding regulation, mechanisms and factors underlying production required. Pituitary adenylate cyclase-activating polypeptide (PACAP) exhibits pleiotropic functions that are mediated via its receptors [PACAP-specific receptor (PAC1R), vasoactive intestinal peptide (VIP) type 1 (VPAC1R) VPAC2R]. Although...
Aims Urinary tract infection ( UTI ) is a common clinical problem in diabetic patients; however, the relationship between and glucosuria remains uncertain. To investigate relationship, we examined effect of induced by sodium glucose cotransporter 2 SGLT2 inhibitors on progression mice. Methods From 1 day before transurethral inoculation with Candida albicans , female mice were treated orally once an inhibitor different treatment regimens: (i) dapagliflozin at 10 mg/kg for 2, 3 or 7 days,...
Background: Heated tobacco products (HTPs) have gained global popularity, but their health risks remain unclear. Therefore, the current study aimed to identify plasma metabolites associated with smoking and HTP use in a large Japanese population improve risk assessment.
Heated tobacco product (HTP) use in Japan has rapidly increased. Despite this rapid spread, little is known about the health effects of HTP use. We conducted a longitudinal cohort study to investigate change smoking habits following spread and its effect on forced expiratory volume 1 second (FEV1) decline.Participants consisted resident population (n = 2,612; mean age, 67.7 years) with FEV1 measurement 2012-2014 2018-2019, worksite 722; age 49.3 without data. Participants were categorized as...
Even though fetal growth restriction and macrosomia remain as major problems currently facing obstetricians, there is still no modality for the assessment of soft tissue deposition muscle mass in utero. A total 52 fetuses from 29 to 41 weeks gestation were studied within 1 week before delivery using a transabdominal three-dimensional (3D) transducer (3.5 MHz). Their birth weights varied 1016 4018 g, their crown–heel length 37 54 cm. The amount subcutaneous was estimated nutrition score....
This study aimed to investigate the risk factors for severe postpartum hemorrhage (PPH) and blood transfusion requirement that are recognizable during any period of pregnancy.We retrospectively reviewed medical data 4829 pregnant women who received care delivered at our institution between July 2010 March 2015. The cohort was divided into patients with without PPH. Multivariate logistic regression analysis performed assess associated same repeated requirement.A total 127 (2.7%) had PPH 43...
Local venous pain caused by dacarbazine (DTIC) injection is due to its photodegradation product 5-diazoimidazole-4-carboxamide (Diazo-IC). The production of Diazo-IC can be decreased protecting the drug from light. Furthermore, reportedly increases with time; however, there are no studies reporting association between preparation time and local DTIC injection. We evaluated efficacy following: (1) method used shorten (2) change diluting solution for DTIC. found that shortening tended decrease...
The categories in the comprehensive lipid and risk management guidelines were proposed by Japan Atherosclerosis Society (JAS Guidelines 2017), which adopted estimated 10 year absolute of coronary artery disease (CAD) incidence Suita score. We examined whether those concordant with degree arterial stiffness.In 2014, cardio-ankle vascular index (CAVI), an stiffness parameter, was measured 1,972 Japanese participants aged 35-74 years Tsuruoka City, Yamagata Prefecture, Japan. mean CAVI...
The anticancer drug dacarbazine (DTIC) is photosensitive, and the photodegradation product 5-diazoimidazole-4-carboxamide (diazo-IC) induces adverse reactions including local venous pain during intravenous injection. In this study we evaluated effectiveness of colored shields (orange red) to protect against DTIC as determined by ascertaining concentration diazo-IC. Samples were prepared stored under four conditions: (1) no shield; (2) covered with an aluminum (opaque) (3) orange (4) a red...