A5035471434- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Properties of Aromatic Compounds
- Fullerene Chemistry and Applications
- Carbon Nanotubes in Composites
- Pancreatic and Hepatic Oncology Research
- Crystallography and molecular interactions
- Photochemistry and Electron Transfer Studies
- Porphyrin and Phthalocyanine Chemistry
- Luminescence and Fluorescent Materials
- Radical Photochemical Reactions
- Hydrology and Watershed Management Studies
- Organic Electronics and Photovoltaics
- Molecular Sensors and Ion Detection
- Pancreatitis Pathology and Treatment
- Retinal Diseases and Treatments
- Supramolecular Chemistry and Complexes
- Flood Risk Assessment and Management
- earthquake and tectonic studies
- Graphene research and applications
- Organic Chemistry Cycloaddition Reactions
- Glaucoma and retinal disorders
- Hydrological Forecasting Using AI
- Photochromic and Fluorescence Chemistry
- Gallbladder and Bile Duct Disorders
Eisai (Japan)
2024-2025
Gunma University
2013-2024
Tottori University
2007-2024
Shiga Medical Center for Children
2023
Tokyo Institute of Technology
2020-2022
Kurume University Hospital
2020-2021
Yokohama Minami Kyosai Hospital
2021
Hokkaido University
2021
Chiba University
2006-2020
Kiryu University
2002-2020
This study aimed to investigate the usefulness of contrast-enhanced endoscopic ultrasonography (EUS) with time-intensity curve (TIC) in differentiating pancreatic diseases.Patients who underwent EUS between January 2007 and June 2009 were analyzed retrospectively, including 48 ductal cancer (PC), 14 autoimmune pancreatitis (AIP), 13 mass-forming (MFP), 16 endocrine tumor (PET). After intravenous injection contrast agent, imaging pattern, TIC-based quantitative evaluation, diagnostic ability...
Lipid droplets (LDs) are closely related to lipid metabolism in living cells and highly associated with diverse diseases such as fatty liver, diabetes, cancer. Herein we describe a π-extended fluorescent coumarin (PC6S) for visualizing LDs the tissues of mice using confocal fluorescence lifetime imaging microscopy (FLIM). PC6S showed large positive solvatochromic shift high quantum yield (>0.80) both nonpolar polar solvents. Additionally, lifetimes were largely dependent on solvent polarity....
The natural history of branch duct-type intraductal papillary mucinous neoplasms (BD-IPMNs) the pancreas remains unclear. We conducted a retrospective long-term follow-up study for malignant transformation (MT) BD-IPMNs focusing on morphological changes.The subjects consisted 142 patients who underwent contrast-enhanced endoscopic ultrasonography initial diagnosis from January 2001 with more than 12 months follow-up. MT rate, including co-occurrence invasive ductal cancer, was evaluated by...
A large series of conjugated carbazole dimers, namely bicarbazoles 1-12, were synthesized by Suzuki-Miyaura, Sonogashira, Hay, and McMurry coupling reactions. In the two moieties are linked at 1-, 2-, or 3-position directly via an acetylenic olefinic spacer. The structure-property relationships, particularly effects conjugation connectivity π-conjugated spacers on electronic, photophysical, electrochemical properties studied extensive UV-vis fluorescence spectroscopic measurements, cyclic...
A series of carbazole-pyrimidine conjugates 1-17 were synthesized by Pd-catalyzed cross-coupling, oxidation, and nucleophilic aromatic substitution reactions. In 1-17, the carbazole moieties are connected at 4,6-positions pyrimidine ring either directly or via ethynylene vinylene spacers, various electron-donating electron-withdrawing substituents introduced 2-position ring. The effects structural variations on electronic, photophysical, electrochemical properties comprehensively...
The preparation of a series dibenzo- and tetrabenzo-fused fluoreno[3,2-b]fluorenes is disclosed, the diradicaloid properties these molecules are compared with those similar, previously reported anthracene-based diradicaloids. Insights on diradical mode delocalization tuning by constitutional isomerism external naphthalenes has been explored means physical approach (dissection electronic in terms repulsion transfer integral) diradicals. This study also extended to redox species two compounds...
AIM:To investigate the usefulness of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in differentiation autoimmune pancreatitis (AIP). METHODS:We retrospectively reviewed 47 56 AIP patients who underwent EUS-FNA and met Asian diagnostic criteria.On specimens, we evaluated presence adequate material characteristic features lymphoplasmacytic sclerosing (LPSP) idiopathic duct-centric (IDCP) mentioned International Consensus Diagnostic Criteria examined if these findings make a...
Abstract Background Intracerebral amyloid β (Aβ) accumulation is considered the initial observable event in pathological process of Alzheimer’s disease (AD). Efficient screening for pathology critical identifying patients early treatment. This study developed machine learning models to classify positron emission tomography (PET) Aβ-positivity participants with preclinical and prodromal AD using data accessible primary care physicians. Methods retrospective observational assessed...
Polymer-supported, palladium-catalyzed cyclization reactions effectively synthesized indolecarboxylates. Palladium-catalyzed carbon-carbon bond-forming of immobilized enaminoesters followed by transesterification yielded indole 2- or 3-carboxylates with various functional groups on the benzene ring. Indolecarboxylates were efficiently cyclized via an intramolecular amination reaction N-substituted dehydrohalophenylalanines, and N-acetyl-dehydroalanines converted into indolecarboxylates...
Three chiral N-methylfulleropyrrolidine bisadducts were prepared, isolated, and completely resolved into each enantiomer using a HPLC column, which then converted to the corresponding optically active, cationic C60-bisadducts investigate if they could act as macromolecular helicity inducer in poly(phenylacetylene) bearing an anionic monoethyl phosphonate pendant (poly-1) aqueous solution. Upon complexation with C60-bisadducts, only trans-3 bisadduct exhibited characteristic induced circular...
In order to accomplish the selective synthesis of [60]fullerene bisadducts, reactions with compounds in which two α,α'-dibromo-o-xylene moieties were connected by an oligomethylene chain (n = 2−5) investigated. By this method, only isomers (cis-2- and cis-3-isomers) selectively obtained when n 2 3, while another isomer (e-isomer) was 5. When 4, a complex mixture bisadducts formed has not been separated so far. cis-2-Bisadducts have been, for first time, fullerene chemistry. The structures...
Effects of electronic structures on the excited-state intramolecular proton transfer (ESIPT) 1-hydroxy-2-acetonaphthone (1H2AN) and its related compounds [1-hydroxy-2-naphthaldehyde (1H2NA) methyl 1-hydroxy-2-naphthoate (1H2MN)] were studied by means laser photolysis method, time-resolved thermal lensing technique, fluorometry. Both 1H2AN 1H2NA showed relatively large Stokes-shifted fluorescence (Δν̄ = 6120 6170 cm-1, respectively) strongly temperature-dependent observed usually for ESIPT...
The [2 + 2] cycloaddition between [60]fullerene and benzyne generated from 4,5-dimethoxyanthranilic acid (4) afforded bisadducts 5 along with the monoadduct. All of eight possible regioisomers were first isolated by HPLC then characterized on basis MS, NMR, UV−vis, CD spectroscopies.
To overlap aromatic rings in cyclophanes, the inter- and intramolecular [2 + 2] photocycloaddition of vinylarenes has been developed. It gives naphthalenophanes, phenanthrenophanes, thiophenophanes, carbazolophanes reasonable to excellent yields. The structures properties cyclophanes obtained are reviewed; especially excimer emission stressed that many intriguing can be through fine molecular design precursors.
The authors investigated bacteriologically the prevalence of Bartonella infection among 690 pet cats derived from 10 private animal hospitals in six cities (Sapporo, Hokkaido Prefecture; Sendai, Miyagi Joetsu, Niigata Fujisawa, Kanagawa Prefecutre; Kyoto, Kyoto Sanda, Hyogo Prefecutre) and 4 counties (Mishima, Osaka Hikawa, Shimane Aira, Kagoshima Shimajiri, Okinawa Prefecture) located north to south Japan. species were isolated 7.2% (50/690) all examined. No Sapporo or Sendai. isolation...
Crowning glory: An unprecedented [2]catenane that exhibits a donor–acceptor–donor–acceptor stacking motif was obtained through intramolecular Bingel reactions of [60]fullerene monoadducts bear naphthalenetetracarboxylic diimide moiety, in the presence 1,5-dinaphtho[38]crown-10 ether at −78 °C (see scheme; DBU=1,8-diazabicyclo[5.4.0]undec-7-ene).
We report the syntheses, structures, photophysical properties, and redox characteristics of donor-acceptor-fused π-systems, namely π-extended thiadiazoles 1-5 fused with thienopyrrole or indole moieties. They were synthesized by Stille coupling reactions followed PPh(3)-mediated reductive cyclizations as key steps. X-Ray crystallographic studies showed that isomeric 1b 2b form significantly different packing from each other, 1a 4a afford supramolecular networks via multiple hydrogen bonding...
A series of thienylcarbazoles were synthesized by Suzuki-Miyaura and Ullmann coupling reactions. In these compounds, the 2-thienyl or 2,2'-bithiophen-5-yl group is connected at N-, 1,8-, 3,6-, 2,7-, 2,7,N-, 1,8,N-positions carbazole ring. The effects structural variations on their electronic, photophysical, electrochemical properties explored UV-vis fluorescence spectroscopies, cyclic voltammetry (CV), DFT calculations in evaluation potential as material components. thienyl substituents...