A5055992387- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Spinal Cord Injury Research
- Cervical and Thoracic Myelopathy
- Anesthesia and Pain Management
- Trauma Management and Diagnosis
- Nerve injury and regeneration
- Bone and Joint Diseases
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Lower Extremity Biomechanics and Pathologies
- Intraoperative Neuromonitoring and Anesthetic Effects
- Neuropeptides and Animal Physiology
- Stroke Rehabilitation and Recovery
- Rheumatoid Arthritis Research and Therapies
- Protease and Inhibitor Mechanisms
- Spinal Hematomas and Complications
- Scoliosis diagnosis and treatment
- Tissue Engineering and Regenerative Medicine
- Immune cells in cancer
- Medical Imaging and Analysis
- Pleural and Pulmonary Diseases
- Elbow and Forearm Trauma Treatment
- Wound Healing and Treatments
- Pediatric Pain Management Techniques
Showa University
2004-2024
Marymount University
1997
University College London
1994
Great Ormond Street Hospital
1994
University of Minnesota
1992-1993
Tokyo Gakugei University
1989
Fukushima Medical University Hospital
1986
Two different methods of treatment for open dislocation the extruded talus without soft tissue attachments (missing talus) were examined. In case 1, a 20-year-old man sustained an total due to motorcycle accident. The missing was found within 3 hr and replaced after thorough washing debridement. Weightbearing permitted at 20 weeks; however, density talar body increased in x-ray nonweightbearing status resumed. Reexamination 2 ½ years revealed that there joint space narrowing on decreased...
Adult human mesenchymal stem/stromal cells (hMSCs) from bone marrow have been reported to exhibit beneficial effects on spinal cord injury (SCI). A neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP) is known decrease neuronal cell death and inflammatory response after ischemia, SCI, other disorders. Recently, we found that expression of the gene for mouse PACAP (Adcyap1) was greater in animals receiving hMSCs with neural such as ischemia. However, association protect...
Human bone marrow-derived mesenchymal stem/stromal cells (hMSCs) have shown potential in facilitating recovery from spinal cord injury (SCI) through communicating with microglia/macrophages (MG/MΦ). We here focused on chemokines as a candidate for the communication. Selected MG/MΦ-related were determined gene expression after SCI and further CCL2/CCR2 CCL5/CCR5 to estimate role of by hMSCs. Male C57/BL6 mice subjected transection. Gene was assayed cords following selected their receptors....
Objective: Severe global ischemia often results in severe damage to the central nervous system of survivors. Hind-limb paralysis is a common deficit caused by ischemia. Until recently, most studies have examined either brain or spinal cord, but not both. Spinal cord specifically after has been studied detail. Because exact nature neuronal and differences between are poorly understood, we developed new model rat Further, compared different forms Design: Randomized, controlled study using...
Pituitary adenylate cyclase-activating polypeptide (PACAP, encoded by adcyap1) plays an important role in ectodermal development. However, the involvement of PACAP development other germ layers is still unclear. This study assessed expression a PACAP-specific receptor (PAC1) gene and protein mouse bone marrow (BM). Cells strongly expressing PAC1(+) were large size, had oval nuclei, merged with CD34(+) cells, suggesting that former hematopoietic progenitor cells (HPCs). Compared wild-type...
Study Design Three inflammatory and adhesive changes inside the spinal canal were analyzed histopathologically in cats. Objective To investigate usefulness of a polyvinyl alcohol hydrogel sheet as an interposition over dura to prevent reaction after laminectomy. Summary Background Data A major concern laminectomy is scar tissue formation that may result extradural compression or make subsequent surgery same area difficult hazardous. Methods Wide was performed at L5 30 adult The covered with...
The Japanese Orthopaedic Association National Registry (JOANR) is Japan's first national registry of orthopaedic surgery, which has been developed after having selected for the Project Developing a Database Clinical Outcome approved by Health Policy Bureau Ministry Health, Labour and Welfare. Its architecture two levels registration, one being basic items surgical procedure, disease, information on surgeons, surgery-related information, outcome, other detailed in affiliated registries...
Study Design: Retrospective cohort study.Purpose: This study aimed to compare data from patients who received intradiscal condoliase (chondroitin sulfate ABC endolyase) injection for primary lumbar disc herniation (LDH) and recurrent LDH.Overview of Literature: Chemonucleolysis with LDH is a treatment relatively good results high safety profile; however, few studies have reported recurrence after surgery.Methods: The participants were 249 underwent at nine participating institutions,...
Intermittent sacral nerve dysfunction, induced by walking in lumbar spinal canal stenosis, may cause symptoms including hyperesthesia and pain perineum, urinary bladder incontinence, penile erection. However, it is difficult to objectively document these symptoms. Evoked external urethral sphincter potentials conus medullaris stimulation were measured both before after five patients who complained of sexual organ or dysfunction during walking, compared with simultaneously These also surgery....
Despite difficulty in long-term maintenance of spinalized rabbits, muscular pathologic changes chronic rabbits could be observed for a period four weeks. Rabbits were prepared by spinal cord transection at T10 (spastic paralysis) or removal below L7 (flaccid paralysis). Spastic preparations showed hind-limb spasticity and reflex incontinence one to two days after operation. Hypertrophic fibers began appear spastic muscles This hypertrophy, thought caused phasic repetitive contraction, was...
Idiopathic osteonecrosis of the medial condyle femur, a relatively common disease among Japanese women 60 years or older, is often progressive and requires surgical treatment. In this paper, we report on case where KAATSU training was effective for 71-year-old woman with bone necrosis in left femoral revealed by magnetic resonance imaging (MRI). At first visit, patient suffering severe pain, unable to walk without cane. After 1 2 months training, her pain mitigated about 3 she able 6 could...
The main purpose of this study was to investigate the usefulness platelet derived wound healing formula (PDWHF) in treatment experimentally induced spinal cord injuries cats. injury model ten adult cats consisted placement three 22-gauge Teflon catheter sheaths into at L2 level. Treatment coating these with PDWHF Hydron. Three animals were used as controls. In 7 remaining cats, double blinded. Cats sacrificed 3 weeks after and injured segments excised for histologic evaluation....
Femoral head avascular necrosis is a condition in which part of the femoral undergoes due to decreased blood flow. The gradually disintegrates causing pain and even today, there are no effective rehabilitation methods other than symptomatic treatment such as decreasing load on hip joints with use cane or walker. We herein describe our insights into this based experience case caused by steroid KAATSU training was found be highly effective. patient 34-year-old woman (154 cm tall weighing 50...
Study Design Graded posterior spinal cord compression and partial sectioning of the were performed, magnetically induced descending potentials recorded. Objectives To compare sensitivity transcranial magnetic motor-evoked in other evoked to lesions. Summary Background Data Somatosensory-evoked have been standard technique for monitoring function during surgery. These potentials, however, do not necessarily reflect motor tract function. Transcranial electric or stimulation is a more direct...
Condoliase-based chemonucleolysis and microendoscopic discectomy (MED) are considered to be minimally invasive treatments for lumbar disc herniation (LDH). The aim of this study was compare the clinical outcomes both treatments, specifically focusing on whether vary by age group. Patients with LDH who received intradiscal condoliase injections (condoliase group) or underwent MED (MED 1-year follow-up were enrolled in study. A numerical rating scale (NRS) developed leg back pains. Using...
In general, cervical cord-injured patients present with restrictive pulmonary dysfunction resulting from paralysis of the intercostal muscles. Vital capacity frequently decreases below 50% that in normal subjects, and their respiratory pattern includes paradoxical movement which spaces sink abdomen distends at inspiration. Ventilation scintigraphy using Xe-133 perfusion Tc-99m macroaggregated albumin (MAA) were performed on nine four subjects to investigate regional lung functions patients....