A5084794851- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Atherosclerosis and Cardiovascular Diseases
- Obesity, Physical Activity, Diet
- Liver physiology and pathology
- Cardiac Imaging and Diagnostics
- Nutritional Studies and Diet
- Liver Diseases and Immunity
- Cardiovascular Function and Risk Factors
- Liver Disease and Transplantation
- Systemic Lupus Erythematosus Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Coronary Interventions and Diagnostics
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Cardiovascular Disease and Adiposity
- Angiogenesis and VEGF in Cancer
- Sleep and related disorders
- Cardiovascular Health and Risk Factors
- Diet and metabolism studies
- Advanced Glycation End Products research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
Tokushima University Hospital
2013-2025
University of Tsukuba
2019-2024
Keio University
2019-2024
Osaka University
2015-2024
Dokkyo Medical University
2024
Juntendo University Hospital
2024
Osaka Medical Center for Cancer and Cardiovascular Diseases
2020-2024
Tokushima University
2010-2024
Ehime University
2024
Weatherford College
2024
Oxidized low density lipoproteins (OxLDL) promote chronic inflammatory responses in the vasculature that give rise to atherosclerotic plaques. Fas ligand (FasL) is naturally expressed on vascular endothelium where it can induce apoptosis Fas-expressing immune cells as they enter vessel wall. Although endothelial are normally resistant Fas-mediated cell death, OxLDL were shown cultured and of arterial explants by a process could be inhibited with L neutralizing antibodies. OxLDL-induced death...
Summary IL-6/STAT-3 signals play key roles in inflammatory bowel disease (IBD). It is known that Lactobacillus casei strain Shirota (LcS) improves disorders. This study aimed to elucidate the effect of LcS on murine chronic IBD and clarify mechanism. We focused inhibitory production IL-6 lipopolysaccharide (LPS)-stimulated large intestinal lamina propria mononuclear cells (LI-LPMC) isolated from mice with colitis RAW264.7 vitro. also determined vivo models induced dextran sodium sulphate...
Abstract. Oral lichen planus (OLP) is a common oral disorder that manifests mucosal reaction to variety of aetiological factors, including liver disorder. This study investigated the relationship between OLP and hepatitis C virus (HCV) infection by studying prevalence B or disease in 45 patients with Northern Kyushu region Japan where HCV highest country. Serum surface antigen (HBsAg) was positive only four patients. anti‐HCV serum RNA 28 (62%) 27 (60%) patients, respectively. The majority...
It is uncertain whether or not apoptosis involved in the pathogenesis of primary biliary cirrhosis (PBC). The aims this study were to assess nuclear DNA fragmentation and expression Bcl-2 epithelial cells (BECs) hepatocytes PBC. Additionally, effects ursodeoxycholic acid (UDCA) on PBC evaluated. Liver tissue specimens from 35 patients examined by situ nick-end labeling detect any fragments, immunohistochemistry for Bcl-2. Ten these underwent a second liver biopsy after treatment with UDCA....
We evaluated the relationship of severity hyperuricemia and flow-mediated vasodilatation brachial artery (FMD) in patients with without metabolic syndrome (MetS).In a cross-sectional study, FMD was obtained 2,732 Japanese healthy men (49 ± 8 years) who had no cardiovascular (CV) disease were not on any medication for CV risk factors. MetS defined according to criteria, serum uric acid (UA) levels upper half fifth (highest) quintile range as severe hyperuricemia, whereas those lower this mild...
This study aimed to examine the association between sleep duration and quality sarcopenia, assessed by factors such as low muscle mass (LMM), strength (LMS), physical performance (LPP) among older community-dwellers in Japan. In this cross-sectional study, a total of 2,069 (men, 902; women, 1,167) participants aged 65 80 years were included. Sarcopenia each function defined using definitions Asian Working Groups 2019. Sleep was stratified into three categories: short (<6 h), normal (6-8 long...
Aims: Nonalcoholic fatty liver disease (NAFLD) is known to be associated with atherosclerosis. This study focused on upstream changes in the process by which NAFLD leads The aimed confirm association between and cardio-ankle vascular index (CAVI), an indicator of subclinical atherosclerosis, explore metabolites involved both assessing 94 plasma polar metabolites.
The presence of Helicobacter pylori (H. pylori) in the natural environment has been demonstrated a number studies. However, its route infection into humans is unknown. To study this further, we attempted to detect H. region Japan with high rate. Tap and well water field soil samples were collected from around residences subjects who had participated an epidemiological survey 1996. Samples rivers ponds, specimens flies cow faeces region. DNA was extracted water, faecal after selective...
Abstract Background Patients with severe aortic valve stenosis undergoing transcatheter replacement (TAVR) present a high prevalence of heart failure preserved ejection fraction (HFpEF). An elevated left atrial stiffness index (LASI) has recently been recognized as potential prognostic factor for worsened outcomes in HFpEF patients. Purpose This study investigates whether the LASI is following TAVR Methods In this single-center retrospective study, patients who underwent at our center from...
Abstract Background It is known that an increase left atrial stiffness associated with poor prognosis in patients heart failure preserved ejection fraction (HFpEF). Purpose We evaluated the predictive utility of non-invasive index (LASI) HFpEF patients, comparing it to other clinical prognostic indicators. Methods Patients were recruited from EASY-HFpEF study, a multicenter prospective observational cohort study Japan involving hospitalized acute decompensated and ventricular &gt;40%....
Oral lichen planus (OLP) is frequently seen in patients with hepatitis C virus (HCV) infection. To clarify the role of HCV OLP pathogenesis, we investigated occurrence and progression oral lesions chronic treated interferon. surgeons examined 24 (15 men, nine women; mean age 48.1 years) for before, during after interferon (IFN) treatment. was observed 16.7% (4/24). Two had before treatment, one Those who developed or treatment neither improvement nor disappearance even when serum RNA became...
Esophageal perforation caused by endoscopic submucosal dissection (ESD) induces serious pneumomediastinum. In the absence of endoscopically detected perforation, postprocedural pneumomediastinum may occur. The aim this study was to evaluate association between clinical factors/courses and revealed chest computed tomography (CT) with special reference an exposed muscle layer during esophageal ESD.A total 58 patients undergoing ESD for neoplasms February 2003 June 2007 also underwent both...
Seaweed is a popular traditional foodstuff in Asian countries. To our knowledge, few studies have examined the association of seaweed intake with mortality from cardiovascular disease. We frequency total and specific disease mortality.We among 40,234 men 55,981 women who participated Japan Collaborative Cohort Study for Evaluation Cancer Risk. Sex-specific hazard ratios (stroke, stroke subtypes, coronary heart disease) according to were calculated stratified by study area adjusted potential...
It is known that mechanical stress induces extracellular matrix via transforming growth factor-beta (TGF-beta) synthesis in vascular smooth muscle cells. Activated hepatic stellate cells (HSCs) are an important source of TGF-beta the liver. However, it remains unclear whether HSCs. The Rho small GTP-binding protein (Rho) has recently emerged as regulator actin and cytoskeleton. We examined expressed stretched HSCs involved stretch-induced synthesis.A cultured human HSC cell line, LI90, was...
Summary. Thymalfasin (thymosin alpha‐1; Tα1) is a 28‐amino acid polypeptide that has shown efficacy in the treatment of chronic hepatitis B virus (HBV) infection. The objective this study was to evaluate long‐term, dose‐related and safety Tα1 patients with positive HBV‐DNA abnormally high alanine aminotransferase (ALT) levels. A total 316 were randomized receive either 0.8 or 1.6 mg monotherapy for 24 weeks. At end 72‐week observation period (12 months after cessation therapy), 36.4% 1.6‐mg...