A5102865997- Computational Drug Discovery Methods
- Antimicrobial Peptides and Activities
- vaccines and immunoinformatics approaches
- Software Reliability and Analysis Research
- Discourse Analysis in Language Studies
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Language, Metaphor, and Cognition
- Metabolomics and Mass Spectrometry Studies
- Remote Sensing and Land Use
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Animal Virus Infections Studies
- Software Testing and Debugging Techniques
- Gynecological conditions and treatments
- Technology and Human Factors in Education and Health
- Occupational Health and Performance
- Melanoma and MAPK Pathways
- Second Language Acquisition and Learning
- Ergonomics and Musculoskeletal Disorders
- Ovarian cancer diagnosis and treatment
- Personality Traits and Psychology
- Seed and Plant Biochemistry
- Heat shock proteins research
Yunnan University
2025
Xuzhou Medical College
2024
Zhujiang Hospital
2024
Southern Medical University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Beijing Institute of Technology
2023
Chongqing University
2019-2021
Kagawa University
2020
Zhejiang University
2017-2020
Xiamen University of Technology
2020
The nematode Caenorhabditis elegans is an important model for the study of social behaviors. Ethyl-dimer-galactopyranoside, a new glycoside isolated from cultures C. on growth medium (NGM), exhibited strong attractive activity toward at different doses, reaching chemotaxis index 0.36 500 pg. Moreover, results transcriptome and assays suggest that ASE neurons are involved in effect ethyl-dimer-galactopyranoside elegans. This supplemented understanding structure biological function modular...
The traditional signalling systems have a high degree of independence, leading to costs in resources and labor. In order reduce the number servers achieve unified management infrastructure, automatic train supervision (ATS) subsystem can be incorporated into cloud platform. deployment scheme for integrating workstations control center platform is described this paper, based on characteristics existing architecture signal ATS. On basis, mode each host interface between ATS other are...
In order to use TPR teaching method effectively in primary school English class, this paper uses the experiment method, two groups of students from Experimental Hongdong County Linfen City are selected as experimental subjects. process experiment, one group taught by another common traditional method. The data shows that is a more effective On basis above research, comes conclusion will greatly enhance students’ learning efficiency. Through research paper, author hopes deepen teachers’...
In order to enhance the security of software, each system update needs perform regression test. Regression testing in a continuous integration environment requires test cases meet rapid feedback. Therefore, it is necessary enable be effectively sorted within certain time range so that more failure data could discovered and fault detection rate improved. Reinforcement learning algorithms interact with environment, viable optimize sorting problem case process through reward mechanism....
Journal Article Protein–ligand interaction fingerprints for accurate prediction of dissociation rates p38 MAPK Type II inhibitors Get access Duo Zhang, Zhang Key Laboratory Biorheological Science and Technology (Ministry Education), Chongqing University, Chongqing, ChinaCollege Bioengineering, China Search other works by this author on: Oxford Academic Google Scholar Shuheng Huang, Huang Hu Mei, Mei Corresponding author: E-mail: meihu@cqu.edu.cn MuliadiYeremia Kevin, Kevin College Tingting...
Accumulated evidence suggests that binding kinetic properties—especially dissociation rate constant or drug-target residence time—are crucial factors affecting drug potency. However, quantitative prediction of properties has always been a challenging task in discovery. In this study, the VolSurf method was successfully applied to quantitatively predict koff values small ligands heat shock protein 90α (HSP90α), adenosine receptor (AR) and p38 mitogen-activated kinase (p38 MAPK). The results...
Although mAbs targeting the programmed cell death protein 1 (PD-1)/programmed ligand (PD-L1) pathway have achieved remarkable therapeutic potential against multiple types of cancer, it is still great interest for researchers to develop small-molecule PD-1/PD-L1 inhibitors without mAb-related disadvantages no oral bioavailability and poor solid tumor penetration. However, with small molecules normally considered challenging because flat large interaction surface complex. In this paper, a...
Cholangiocarcinoma is the most common biliary duct malignancy and second primary liver cancer, accounting for 10‑20% of hepatic malignancies. With high mortality poor prognosis, 5‑year survival rate cholangiocarcinoma only 10%. A previous study demonstrated a significant association between aspirin use decreased risk cholangiocarcinoma. However, effect on remains unknown. Therefore, aim present was to investigate effects in vitro vivo. Three cell lines were used analyze proliferation, cycle...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal of digestive tract. The angiotensin II type 1 receptor blockers, telmisartan and candesartan, widely used antihypertensive drugs that inhibits cancer cell proliferation; however, its underlying mechanisms in tumors, including GIST, remains unknown. present study aimed to investigate effect on GIST‑T1 cells mechanism. Telmisartan candesartan inhibited proliferation these by blocking G0 G1 cycle transition, which was...
Human leukocyte antigens (HLAs) play a critical role in human-acquired immune responses by the recognition of non-self-peptides derived from exogenous bacteria, fungi, virus, and so forth. The accurate prediction HLA-binding peptides is thus extremely useful for mechanistic research cell-mediated immunity related epitope-based vaccine design. In this work, simple pan-specific gated recurrent unit (GRU)-based neural network model was successfully proposed predicting HLA-I-binding peptides....
With the development of computer and image processing technology, recognition technology has been applied to national medicine resources census work at all stages.Among them: ①In preparatory work, in order establish a unified library traditional Chinese resources, using text based on paper materials, be assistant digitalization various categories related resources; determine representative area plots survey from each team, satellite remote sensing vegetation map other basic data,...
Abstract Background Smilax china L. (SCL) is a traditional herbal medicine for the potential treatment of intrauterine adhesion (IUA). However, mechanisms action have not yet been determined. In this study, we explored effects and SCL in IUA by network pharmacology, molecular docking biology experiments. Methods Active ingredients targets were acquired from TCMSP SwissTargetPrediction. IUA-related collected GeneCards, DisGeNET, OMIM TTD databases. A protein‒protein interaction (PPI) was...
Premembrane (prM) is a viral protein of flavivirus, which important for the generation infectious virion and virus infection to host. However, biological properties function prM Avian Tembusu (ATMUV) have scarcely been studied date. Monoclonal antibodies (mAbs) are powerful tool functional analysis protein. To produce mAb against ATMUV, gene sequence was amplified by reverse transcription polymerase chain reaction (RT-PCR) cloned into prokaryotic expression vector pET-28a (+). The...
Due to the potencies in treatments of cancer, infectious diseases, and autoimmune developments human TLR8 (hTLR8) agonists antagonists have attracted widespread attentions. The hTLR8 similar structures but with completely opposite biological effects. Up date, subtle differences between are still unknown. In this work, emerging chemical pattern (ECP) was successfully used extract key patterns antagonists. By using CAEP classifier, an optimal ECP model only 3 descriptors established overall...
Communicated by Ramaswamy H. Sarma