A5040221189- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Health and Disease Prevention
- Parathyroid Disorders and Treatments
- Peripheral Artery Disease Management
- Cardiac Arrhythmias and Treatments
- Hormonal Regulation and Hypertension
- Acute Ischemic Stroke Management
- Heart Rate Variability and Autonomic Control
- Neurological Disease Mechanisms and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Diabetes Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Cancer Treatment and Pharmacology
- Renin-Angiotensin System Studies
Kumamoto University
2016-2025
Kumamoto University Hospital
2013-2023
Amyloidosis Foundation
2021
Research Network (United States)
2021
Kumamoto City Hospital
2021
Miyazaki Prefectural Hospital
2021
Weatherford College
2019
Suzuki (Japan)
2019
National Cerebral and Cardiovascular Center
2016
Mie University
2011-2013
There has been uncertainty regarding the benefit of glycemic control with antidiabetic agents in prevention diabetic macrovascular disease. Further development novel is essential for overcoming burden The renal sodium glucose co-transporter 2 (SGLT2) inhibitor a antihyperglycemic agent treatment type diabetes. This work was performed to determine whether empagliflozin, SGLT2 inhibitor, can ameliorate cardiovascular injury and cognitive decline db/db mouse, model obesity diabetes.(1)...
The purpose of this work was to test whether brain-penetrating angiotensin-converting enzyme (ACE) inhibitors (e.g., perindopril), as opposed non-brain-penetrating ACE enalapril and imidapril), may reduce the cognitive decline brain injury in Alzheimer's disease (AD). We first compared effect perindopril, enalapril, imidapril on impairment a mouse model AD induced by intracerebroventricular (i.c.v.) injection amyloid-β (Aβ)1–40. Perindopril, with significant inhibition hippocampal ACE,...
BACKGROUND: The optimal duration of anticoagulation therapy for isolated distal deep vein thrombosis in patients with cancer is clinically relevant, but the evidence lacking. prolonged could have a potential benefit prevention thrombotic events; however, it also increase risk bleeding. METHODS: In multicenter, open-label, adjudicator-blinded, randomized clinical trial at 60 institutions Japan, we randomly assigned thrombosis, 1-to-1 ratio, to receive either 12-month or 3-month edoxaban...
In contrast to the antihypertensive effect of esaxerenone, there is little evidence its cardioprotective effect. We investigated efficacy and safety esaxerenone in patients with uncontrolled hypertension left ventricular hypertrophy taking a renin-angiotensin system inhibitor (RASi) or calcium-channel blocker (CCB). This was multicenter, open-label, exploratory study 24-week treatment period. Esaxerenone orally administered at an initial dose 2.5 mg/day (maximum dose: 5 mg/day). The primary...
The role of the renin-angiotensin system in cognitive impairment is unclear. This work was undertaken to test our hypothesis that may contribute decline and brain damage caused by chronic cerebral ischemia. C57BL/6J mice were subjected bilateral common carotid artery stenosis with microcoil prepare hypoperfusion, a model subcortical vascular dementia. effects aliskiren, direct renin inhibitor, or Tempol, superoxide scavenger, on working memory these examined. Chronic hypoperfusion...
LCZ696 (sacubitril/valsartan) can lower the risk of cardiovascular events in chronic heart failure. However, it is unclear whether improve prognosis patients with acute myocardial infarction (MI). The present study shows that prevent cardiac rupture after MI, probably due to suppression pro-inflammatory cytokines, matrix metalloproteinase-9 activity and aldosterone production, enhancement natriuretic peptides mice. These findings suggest mechanistic insight cardioprotective effects against...
There are currently no specific strategies for the treatment or prevention of vascular dementia. White matter lesions, a common pathology in cerebral small vessel disease, major cause We investigated whether apoptosis signal-regulating kinase 1 (ASK1) might be key molecule hypoperfusion, associated with blood-brain barrier breakdown and white lesions.A mouse model cognitive impairment was developed by inducing chronic hypoperfusion including corpus callosum via bilateral carotid artery...
BACKGROUND LCZ696, an angiotensin receptor-neprilysin inhibitor, has recently been demonstrated to exert more beneficial effects on hypertensive or heart failure patients than conventional renin-angiotensin system blockers. However, the mechanism underlying benefit of LCZ696 remains be understood. The present study was undertaken examine effect compared with valsartan hypertension and cardiovascular injury. METHODS (i) Using telemetry, we hypotensive in spontaneously rats (SHR) that were fed...
Statin therapy reduces the risk of cardiovascular events in patients with obstructive coronary artery disease. The aim present study was to determine effects statins on prognosis vasospastic angina (VSA) free significant atherosclerotic stenosis.After exclusion 475 from 1877 consecutive who underwent an acetylcholine-provocation test between January 1991 and December 2010, data 640 VSA without organic stenosis remaining 1402 were analyzed retrospectively. Propensity score matching performed...
Abstract Background The H2FPEF score is recognized as a simple method to diagnose heart failure (HF) with preserved left ventricular ejection fraction (HFpEF). We investigated the value of in predicting subsequent cardiovascular events HFpEF patients. Methods This study was retrospective, single-center, observational study. calculated scores for 404 consecutive Subjects were subdivided into low- (0–3), intermediate- (4–6), and high-score (7–9) groups followed 50 months. primary secondary...
With the advancement in successfully treating different types of cancers, there is an immediate and increased need to focus on risk complexity cardiovascular events cancer survivors. This has led emergence onco-cardiology/cardio-oncology field. We examined varying incidence after percutaneous coronary intervention (PCI) patients with or without cancer.Participants were divided into a non-malignant group malignant group, consisting who receiving had ever received treatment. The primary...
Current guidelines recommend several direct oral anticoagulant agents (DOACs) equally for managing cancer-associated venous thromboembolism (VTE). The aim of this study was to assess the efficacy and safety DOACs in patients with active cancer. Literature searches were conducted PubMed, Embase, Cochrane Central November 2022. Randomized controlled trials investigating anticoagulation strategies (vitamin K antagonists, parenteral [eg, low-molecular weight heparin], DOACs) VTE cancer...
Abstract Aims There are minimal data on the prognostic impact of right atrial strain during reservoir phase (RASr) in patients with immunoglobulin light‐chain (AL) cardiac amyloidosis. Methods and results Among 78 who were diagnosed AL amyloidosis at Kumamoto University Hospital from 2007 to 2022, 72 sufficient two‐dimensional speckle tracking imaging without chemotherapy before diagnosis retrospectively analysed. During a median follow‐up 403 days, 31 deaths occurred. Age rate male sex not...
Abstract Aims Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is often accompanied by atrial fibrillation (AF), flutter (AFL), and tachycardia (AT), which are difficult to control because beta-blockers antiarrhythmic drugs can worsen heart failure (HF). This study aimed investigate the outcomes of catheter ablation (CA) for AF/AFL/AT in patients with ATTRwt-CM propose a treatment strategy CA. Methods results A cohort was conducted on 233 diagnosed ATTRwt-CM, including 54 who...
It remains to be elucidated whether dipeptidylpeptidase-4 (DPP-4) inhibitor can ameliorate cardiovascular injury in salt-sensitive hypertension. The present study was undertaken test our hypothesis that linagliptin, a DPP-4 inhibitor, administration initiated after onset of hypertension and cardiac hypertrophy Dahl hypertensive rats (DS rats). High-salt loaded DS with established were divided into two groups, orally given (1) vehicle or (2) linagliptin (3 mg/kg/day) once day for 4 weeks,...
Abstract Aims The focus on wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is increasing because of novel treatment options. There currently no report a large number Japanese patients with ATTRwt‐CM. study aimed to examine the characteristics and prognosis ATTRwt‐CM in Japan. Methods results Consecutive (78.5 ± 6.4 years old at diagnosis) diagnosed Kumamoto University Hospital between December 2002 2019 were retrospectively reviewed. Data, including demographic characteristics,...
Abstract Aims There are few data on the prognostic impact of pulmonary-right ventricular (RV) uncoupling in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). Methods and results Among 174 who were diagnosed ATTRwt-CM at Kumamoto University Hospital from 2002 to 2021, 143 met current Japanese guideline had sufficient information for two-dimensional speckle tracking echocardiography retrospectively analysed. During a median follow-up 1209 days, 39 cardiac deaths...