Wataru Shioyama
A5023401502- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Function and Risk Factors
- Cardiac tumors and thrombi
- Cardiac Imaging and Diagnostics
- Cancer Treatment and Pharmacology
- Antiplatelet Therapy and Cardiovascular Diseases
- Pulmonary Hypertension Research and Treatments
- Acute Ischemic Stroke Management
- Central Venous Catheters and Hemodialysis
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Lung Cancer Treatments and Mutations
- Peroxisome Proliferator-Activated Receptors
- Protein Tyrosine Phosphatases
- Kruppel-like factors research
- Cardiovascular Issues in Pregnancy
- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
- HER2/EGFR in Cancer Research
- Viral-associated cancers and disorders
- Renal cell carcinoma treatment
- Angiogenesis and VEGF in Cancer
Shiga University of Medical Science
2021-2025
Osaka International Cancer Institute
2017-2022
Osaka Medical Center for Cancer and Cardiovascular Diseases
2015-2016
Osaka University
2007-2012
The University of Tokyo
2011
The purpose of this study was to assess osimertinib-associated cardiac adverse events (AEs) in a real-world setting, using retrospective single-center cohort Japan. Cases AEs have been reported but remain poorly understood. A total 123 cases advanced non–small cell lung cancer (NSCLC) with confirmed EGFR mutations who received osimertinib monotherapy from 2014 2019 at the Osaka International Cancer Institute (Osaka, Japan) were evaluated. Cardiac defined according Common Terminology Criteria...
Grb2-associated binder (Gab) docking proteins, consisting of Gab1, Gab2, and Gab3, have crucial roles in growth factor-dependent signaling. Various proangiogenic factors regulate angiogenesis endothelial function. However, the Gab proteins remain elusive.To elucidate role postnatal angiogenesis.Endothelium-specific Gab1 knockout (Gab1ECKO) mice were viable showed no obvious defects vascular development. Therefore, we analyzed a hindlimb ischemia (HLI) model control, Gab1ECKO, or conventional...
Background An association between uric acid (UA) and cardiovascular diseases, including heart failure (HF), has been reported. However, whether UA is a causal risk factor for HF controversial. In particular, the prognostic value of lowering in patients with preserved ejection fraction (HFpEF) unclear. Methods Results We enrolled HFpEF from PURSUIT‐HFpEF (Prospective Multicenter Observational Study Patients With Heart Failure Preserved Ejection Fraction) registry. investigated was correlated...
Angiogenesis inhibitors, such as sorafenib and axitinib, which target vascular endothelial growth factor (VEGF) signaling, are widely used for renal cell carcinoma, including metastasis. In this study, we report a case of cardiovascular adverse events aortic dissection cardiac dysfunction during treatment with axitinib metastatic carcinoma. A 66-year-old man had been administered 2 years after nephrectomy due to To control the progression lung tumor, was started four years. During treatment,...
Background Real-world data on clinical characteristics and outcomes related to the use of different direct oral anticoagulants (DOACs) for cancer-associated venous thromboembolism (VTE) is lacking. Methods The COMMAND VTE Registry-2 a multicenter registry enrolling 5,197 consecutive patients with acute symptomatic from 31 centers in Japan January 2015 August 2020. Our study population comprised 1,197 active cancer who were divided into edoxaban (N = 643, 54%), rivaroxaban 297, 25%), apixaban...
Background: Patients with appropriately selected low-risk pulmonary embolism (PE) can be treated at home, although it has been controversial whether applies to patients cancer, who are considered not low risk.
Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a life‐threatening complication post‐acute embolism (PE). The assessment of CTEPH incidence and risk factors PE in the era direct oral anticoagulants remains insufficient. Methods Results COMMAND VTE Registry‐2 (contemporary management outcomes patients with venous thromboembolism registry‐2) multicenter registry that recruited consecutive acute symptomatic from 31 centers across Japan. primary outcome was to demonstrate...
Pulmonary arterial hypertension (PAH) is a progressive disease with high mortality. An orally active dual endothelin (ET) receptor antagonist, bosentan, has been reported to improve exercise capacity and survival in patients PAH. Plasma ET-1 concentration known be increased PAH patients; however, the effect of bosentan on not yet investigated.The after administration was examined 7 patients, including 2 primary 5 secondary cases. They were clinically assessed by pulmonary artery pressure...
It is not known whether clopidogrel use in cytochrome P450 (CYP) 2C19 loss-of-function (LOF) carriers with high bleeding risk (HBR) contributes to adverse outcomes after percutaneous coronary intervention (PCI).
A 45-year-old man with chronic active Epstein-Barr virus (EBV) infection (CAEBV) natural killer cell type developed pulmonary arterial hypertension (PAH). After chemotherapy, he showed marked depression of the EBV DNA genome in peripheral blood, but PAH sustained. He died heart failure due to PAH, and histo-pathological examination revealed vascular abnormalities without lung disease on autopsy. Although infiltrating lymphocytes were not detected lung, his clinical course suggested that...
Background: Docking protein Grb2-associated binder 1 (Gab1) has critical roles in signal transduction of various growth factors, cytokines, and numerous other molecules. Our previous reports show that Gab1 is essential for postnatal angiogenesis through the analysis endothelium-specific knockout (Gab1ECKO) mice. However, role atherosclerosis remains unknown. The aim present study was to elucidate endothelial vascular inflammation atherosclerosis. Methods Results: We intercrossed Gab1ECKO...
Objective Oral anticoagulants (OACs), which include direct oral (DOACs) and warfarin, are widely used for the prevention of thromboembolic events in patients with atrial fibrillation (AF). Cancer is associated a prothrombotic state as well an increased bleeding risk. Few data available on efficacy safety OACs Japanese cancer AF. We sought to investigate this population. Methods This retrospective cohort study included active whom AF was recorded by electrocardiography our hospital from...
Abstract The index for a target that can lead to improved prognoses and more reliable therapy in each heterogeneous patient with heart failure preserved ejection fraction (HFpEF) remains be defined. We examined the heterogeneity cardiac performance of patients HFpEF by clarifying relationship between indices left atrial (LA) volume (LAV) overload pressure echocardiography. enrolled (N = 105) who underwent transthoracic echocardiography during stable sinus rhythm. Relative LAV was evaluated...
Immune checkpoint inhibitor (ICI)-induced myocarditis is a potentially life-threatening adverse event. We herein report rare case of sick sinus syndrome (SSS) co-occurring with ICI-associated myocarditis. A 71-year-old woman lung cancer undergoing pembrolizumab monotherapy was admitted owing to fever, worsening kidney function, and bradycardia. She diagnosed multi-organ immune-related events, including Pulse steroid therapy initiated immediately under the support temporary pacemaker, which...
Aim: To investigate the incidence and in-hospital mortality of acute myocardial infarction (AMI) by conforming to Universal Definition Myocardial Infarction (UDMI) in a population-based registry.
The effect of incidental pulmonary embolism (PE) on long-term prognosis in cancer patients is unclear. This study assessed the characteristics and venous thromboembolism (VTE) PE identified by oncologists survival with cancer.
Atrial fibrillation after surgery is associated with increased rates of heart failure and ischemic stroke, extension hospitalization. Bisoprolol a β-blocker used to reduce rate manage arrhythmias during atrial fibrillation. However, the safety efficacy bisoprolol transdermal patch treatment in patients postoperative remain unclear.We retrospectively assessed electronic health records our hospital between September 2013 July 2018 identified who had been treated patch. We excluded sinus rhythm...
Background: The optimal duration of anticoagulation therapy for patients with cancer and acute low-risk pulmonary embolism (PE) is clinically relevant, but evidence lacking. Prolonged could have a potential benefit prevention thrombotic events; however, it also increase the risk bleeding. Methods: In multicenter, open-label, adjudicator-blinded, randomized clinical trial at 32 institutions in Japan, we randomly assigned PE simplified version Pulmonary Embolism Severity Index score 1, 1:1...