A5101418033- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Coronary Interventions and Diagnostics
- Pharmacy and Medical Practices
- Plant and Fungal Interactions Research
- Cardiac electrophysiology and arrhythmias
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Plant Pathogens and Fungal Diseases
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Neuroscience and Neuropharmacology Research
- Plant Disease Resistance and Genetics
- Cardiovascular Function and Risk Factors
- Plant Virus Research Studies
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Plant Disease Management Techniques
- Neurotransmitter Receptor Influence on Behavior
- Yeasts and Rust Fungi Studies
- Venous Thromboembolism Diagnosis and Management
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical Practices and Patient Outcomes
- Acute Myocardial Infarction Research
- Pain Mechanisms and Treatments
Osaka Rosai Hospital
2015-2024
The University of Tokyo
2000-2024
Tokyo University of Information Sciences
2024
Tohoku Medical and Pharmaceutical University
2005-2024
Komatsu (Japan)
2012-2024
Takeda (Japan)
2004-2024
National Agriculture and Food Research Organization
2010-2020
Jikei University School of Medicine
1986-2020
Institute of Fruit Tree and Tea Science
2004-2020
The Japanese Society of Gastroenterological Surgery
2020
Endostatin, a fragment of collagen XVIII, is potent antagonist angiogenesis and inhibitor tumor growth in mouse models. At present, the mechanism action endostatin unknown. We show here that recombinantly produced human interacts with α 5 - v -integrins on surface endothelial cells. further demonstrate endostatin–integrin interaction functional significance vitro , as we found immobilized supports cell survival migration an integrin-dependent manner. Soluble turn inhibits functions, such...
Abstract Background β ‐caryophyllene ( BCP ) is a common constitute of the essential oils numerous spice, food plants and major component in C annabis . The present study investigated contribution peripheral cannabinoid CB opioid systems antinociception produced by intraplantar (i.pl.) injection interaction between morphine was also examined. Methods antinociceptive effect i.pl. assayed capsaicin tests mice. Antagonists for receptors, antisera against ‐endorphin were injected peripherally...
c-Jun N-terminal kinases (JNKs) are potently activated by a number of cellular stimuli. Small GTPases, in particular Rac, responsible for initiating the activation JNK pathways. So far, signals leading from extracellular stimuli to Rac have remained elusive. Recent studies demonstrated that Src homology 2 (SH2)- and 3 (SH3)-containing adaptor protein Crk is capable activating when ectopically expressed. We found here transient expression induces activation, this was dependent on both SH2-...
White root rot, caused by Rosellinia necatrix, is a serious soilborne disease of fruit trees and other woody plants. R. necatrix isolate W370 contains 12 segments double-stranded RNA (dsRNA) that believed to represent possible member the family Reoviridae. was weakly virulent its hyphal-tip strains became dsRNA free strongly virulent. The W370dsRNA were transmitted hygromycin B-resistant strain RT37-1, derived from dsRNA-free in all or none fashion through hyphal contact with W370....
In general, mycoviruses are transmitted through hyphal anastomosis between vegetatively compatible strains of the same fungi, and their entire intracellular life cycle within host fungi limits transmission to separate species even incompatible belonging species. Based on field observations white root rot fungus, Rosellinia necatrix, we found two interesting phenomena concerning mycovirus epidemiology. Specifically, apple trees in an orchard were inoculated with one or R. necatrix that...
The effects of a very short ischemic insult on hilar somatostatin (SS) neurons were investigated in the gerbil hippocampus by means immunocytochemistry and situ hybridization histochemistry. A selective significant loss 40% SS took place after 1 day, 60% 7 days following 2 min ischemia, while no lost during recirculation ischemia. Repeated 2-min periods which induced tolerance vulnerable CA1 neurons, caused almost complete neurons. This study clearly demonstrates that are more to than...
It has been postulated that oxygen-derived free radicals are produced in significant quantities upon reperfusion of ischemic brain and the play a pivotal role triggering neuronal damage causing delayed death. This study was undertaken to examine effects human recombinant superoxide dismutase on death CA1 neurons change expression messenger ribonucleic acid for endogenous copper-zinc after transient ischemia.Human (8 x 10(5) units/kg) or apo-superoxide administered intravenously 1 minute...
Several studies have shown the serum high sensitive cardiac troponin I (hs-TnI) a biomarker of myocardium injury, and C-reactive protein (CRP), inflammation, are associated with worse cardiovascular outcomes. We evaluated relationship between hs-TnI level in patients paroxysmal atrial fibrillation (PAF) after pulmonary vein isolation (PVI) (AF) recurrence.We enrolled 263 consecutive PAF who underwent PVI from May 2017 to April 2018. investigated difference myocardial injury marker (serum...
Background An association between uric acid (UA) and cardiovascular diseases, including heart failure (HF), has been reported. However, whether UA is a causal risk factor for HF controversial. In particular, the prognostic value of lowering in patients with preserved ejection fraction (HFpEF) unclear. Methods Results We enrolled HFpEF from PURSUIT‐HFpEF (Prospective Multicenter Observational Study Patients With Heart Failure Preserved Ejection Fraction) registry. investigated was correlated...
Study Design. Case report of a patient who underwent new surgical procedure for paraplegia after vertebral collapse due to osteoporosis. Objectives. To propose approach posterior spinal fusion surgery osteoporotic patients. Summary Background Data. Surgical treatment was performed on paraplegic However, the difficult because implants such as hooks and screws often dislodged during treatment. The poor holding power these spine is challenging problem in this Methods. When fractured vertebra...
Neutrophil elastase (NE) is known to be one of the most potent proteases capable deforming and detaching human bronchial epithelial cells (BECs) inducing IL-8 gene expression. However, mechanisms NE-induced expression are unclear, especially with respect how they relate cellular detachment. To elucidate these mechanisms, effects cell detachment deformation following mechanical injury or pharmacologic stimuli on were examined by Northern analyses. When BET-1A from a line incubated NE (100...
To assess the role of Cu-Zn superoxide dismutase (CuZnSOD) in regulating cellular antioxidant defenses, we studied induction CuZnSOD mRNA by an situ hybridization technique and protein immunocytochemical method gerbil hippocampus following 5 min transient global ischemia. For hybridization, synthesized 48-mer oligonucleotide (base 465–512) complementary to rat mRNA. Northern blot analysis showed a single band molecular weight 0.65 kb. After ischemia, signal became stronger at 3 24 h returned...
This study investigated the effect of bergamot essential oil (BEO) or linalool, a major volatile component BEO, on nociceptive response to formalin. Plantar subcutaneous injection BEO linalool into ipsilateral hindpaw reduced both first and late phases formalin-induced licking biting responses in mice. contralateral did not yield an antinociceptive effect, suggesting that formalin test occurred peripherally. Intraperitoneal plantar pretreatment with naloxone hydrochloride, opioid receptor...
Schizophyllum commune is a sap-rot basidiomycete and cosmopolitan species. The fungus also recognized as plant pathogen that causes wood rot on living trees, many species including fruit ornamental trees have been recorded hosts. In this paper, previous studies the parasitism of S. related information to date were reviewed, in addition unique characters fungus. Though only poor decomposer vitro, it preferably invades tissues plants bark sapwood, being exceptional wood-rot basidiomycete....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (+-)-dendrobineKiyoyuki Yamada, Masaaki Suzuki, Yoshihiro Hayakawa, Kouzou Aoki, Hitoshi Nakamura, Hiroshi Nagase, and Yoshimasa HirataCite this: J. Am. Chem. Soc. 1972, 94, 23, 8278–8280Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://doi.org/10.1021/ja00778a083RIGHTS & PERMISSIONSArticle Views600Altmetric-Citations42LEARN ABOUT THESE METRICSArticle...
ABSTRACT Rosellinia necatrix mycoreovirus 3 (W370) (RnMYRV-3/W370, described as RnMYRV-3 in this paper), a member of the newly established genus Mycoreovirus within family Reoviridae, is hypovirulence factor white root rot fungus, necatrix. Two virus-free fungal isolates (W37 and W97) that were somatically incompatible with virus-harboring field isolate transfected purified particles. Virus infection was confirmed by electrophoresis northern hybridization viral double-stranded RNA....