A5065221419- Fluid Dynamics and Turbulent Flows
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Complex Systems and Time Series Analysis
- Advanced biosensing and bioanalysis techniques
- Gas Sensing Nanomaterials and Sensors
- Atrial Fibrillation Management and Outcomes
- Wind and Air Flow Studies
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Analytical Chemistry and Sensors
- Orthopaedic implants and arthroplasty
- Plant Water Relations and Carbon Dynamics
- Spine and Intervertebral Disc Pathology
- Meteorological Phenomena and Simulations
- Cervical and Thoracic Myelopathy
- Acute Myocardial Infarction Research
- Total Knee Arthroplasty Outcomes
- Particle Dynamics in Fluid Flows
- Endoplasmic Reticulum Stress and Disease
- Microwave Engineering and Waveguides
- Cytomegalovirus and herpesvirus research
- Chemotherapy-induced cardiotoxicity and mitigation
Université Claude Bernard Lyon 1
2021-2025
École Centrale de Lyon
2021-2025
Institut National des Sciences Appliquées de Lyon
2021-2025
Centre National de la Recherche Scientifique
2021-2024
Osaka University
2012-2024
Hirosaki National Hospital
2024
Tokyo University of Science
2024
Otemae Hospital
2019-2024
Laboratoire de Mécanique des Fluides et d'Acoustique
2021-2024
Hirosaki University
2020-2023
Rationale: Doxorubicin is an effective chemotherapeutic agent for cancer, but its use often limited by cardiotoxicity. causes endoplasmic reticulum (ER) dilation in cardiomyocytes, and we have demonstrated that ER stress plays important roles the pathophysiology of heart failure. Objective: We evaluated role doxorubicin-induced cardiotoxicity examined whether chemical chaperone could prevent cardiac dysfunction. Methods Results: confirmed doxorubicin caused mouse hearts, indicating may...
Background An association between uric acid (UA) and cardiovascular diseases, including heart failure (HF), has been reported. However, whether UA is a causal risk factor for HF controversial. In particular, the prognostic value of lowering in patients with preserved ejection fraction (HFpEF) unclear. Methods Results We enrolled HFpEF from PURSUIT‐HFpEF (Prospective Multicenter Observational Study Patients With Heart Failure Preserved Ejection Fraction) registry. investigated was correlated...
In three-dimensional turbulence, information of turbulent fluctuations at large scales is propagated to small scales. Here, we investigate the relation between flow and described by a shell model. We first establish connection phase-space contraction rate. From this relation, then prove an inequality fluctuations, which suggests that from amplifies This can also be interpreted as quantification Landau's objection universality fluctuations. discuss differences Kolmogorov-Sinai entropy....
While total knee arthroplasty (TKA) and hip (THA) lead to excellent clinical outcomes, some patients experience residual surgical site pain reduced satisfaction. This prospective observational study investigated the prevalence of preoperative postoperative central sensitization (CS) after TKA THA. The influence CS on improvement in quality life (QOL) was also investigated.The participants were 40 who underwent 47 measured using inventory (CSI) questionnaire. Knee symptoms evaluated Injury...
We investigate the nature of information flow in turbulence from an information-thermodynamic viewpoint. For fully developed three-dimensional fluid described by fluctuating Navier-Stokes equation, we prove that large-scale eddies is transferred to small scales along with energy cascade. numerically illustrate our findings using a shell model and further show inertial range, intensity nearly constant can be scaled large-eddy turnover time. Our numerical results also suggest corresponding...
Immunosuppressive agents are used for the treatment of immune-mediated myocarditis; however, need to develop a more effective therapeutic approach remains. Nano-sized liposomes may accumulate in and selectively deliver drugs an inflammatory lesion with enhanced vascular permeability. The aims this study were investigate distribution liposomal FK506, immunosuppressive drug encapsulated within liposomes, drug's effects on cardiac function rat experimental autoimmune myocarditis (EAM) model. We...
Abstract The index for a target that can lead to improved prognoses and more reliable therapy in each heterogeneous patient with heart failure preserved ejection fraction (HFpEF) remains be defined. We examined the heterogeneity cardiac performance of patients HFpEF by clarifying relationship between indices left atrial (LA) volume (LAV) overload pressure echocardiography. enrolled (N = 105) who underwent transthoracic echocardiography during stable sinus rhythm. Relative LAV was evaluated...
Erythropoietin (EPO) has antiapoptotic and tissue-protective effects, but previous clinical studies using high-dose EPO have not shown cardioprotective probably because of platelet activation a lack knowledge regarding the optimal dose. In contrast, small pilot study low-dose improvement in left ventricular function without adverse cardiovascular events.Methods Results:We performed multicenter (25 hospitals), prospective, randomized, double-blind, placebo-controlled, dose-finding to clarify...
We investigate how inhomogeneity influences the $k^{-5/3}$ inertial range scaling of turbulent kinetic energy spectra (with $k$ wavenumber). For weak statistical inhomogeneity, spectrum can be described as an equilibrium plus a perturbation. Theoretical arguments suggest that this latter contribution scales $k^{-7/3}$ . This prediction is assessed using direct numerical simulations three-dimensional Kolmogorov flow.
A retrospective study.To compare long-term clinical and radiologic outcomes between conventional double-door laminoplasty (LP) (group A) cervical LP with C3 laminectomy B).Cervical preserving the semispinalis cervicis inserted into axis decreased patients' postoperative axial pain muscle atrophy, prevented interlaminar bony fusion, limitations of daily living activity, including reduced neck mobility, maintained range motion (ROM) more effectively than reattaching in short-term.Group...
Abstract The coexistence of heart failure is frequent and associated with higher mortality in patients type 2 diabetes (T2DM), its management a critical issue. WATCH-DM risk score tool to predict mellitus (T2DM). We investigated whether it could estimate outcomes T2DM preserved ejection fraction (HFpEF). was calculated 418 hospitalized for HFpEF (male 49.5%, age 80 ± 9 years, HbA1c 6.8 1.0%), they were divided into the “average or lower” (≤ 10 points), “high” (11–13 points) “very high” (≥ 14...
There are few methods available for injectable liposome production under good manufacturing practices (GMP). Injectable processes GMP generally consist of formation, size homogenization, organic solvent removal, concentration control and sterilization. However, these complicated separate make it difficult to maintain scalability, reproducibility sterility. To overcome limitations, we developed a novel one-step in-line closed system that integrated all by combining the thermal mixing device...
Background: Interatrial septum pacing (IAS‐P) decreases atrial conduction delay compared with right appendage (RAA‐P). We evaluate the contraction strain rate of tissue Doppler imaging (TDI) during sinus activation or IAS‐P RAA‐P. Methods: Fifty‐two patients permanent pacemaker for node disease were enrolled in study. Twenty‐three subjects and 29 The time from end‐diastole to peak end‐diastolic was measured corrected RR interval on electrocardiogram. It defined as (TSRc), balance between...
Coronary artery fistulas, including coronary pulmonary are usually discovered accidently among the adult population when undergoing invasive angiographies. We report here a 58-year-old woman with dual fistulas originating from left anterior descending and right sinus to main artery, demonstrating noninvasively multidetector-computed tomography (MDCT) transthoracic echocardiography (TTE).
We demonstrated that the DNA metallization technique using reducing group-labeled intercalator molecules permits dsDNA (double-stranded DNA) to be specifically metallized while not permitting of ssDNA (single-stranded molecules. First, and were stretched on a mica surface spin-coating technique, process was conducted. AFM observation showed only metallized, resulting in formation nanowires with diameter about 11 nm. Secondly, immobilized between two microelectrodes. Impedance analysis...
Identifying the differences between gene regulatory networks under varying biological conditions or external stimuli is an important challenge in systems biology. Several methods have been developed to reverse-engineer a cellular system, called network, from expression profiles order understand transcriptomic behavior various of interest. Conventional infer network independently each multiple find relations for understanding behavior. However, inferred with conventional include large number...
Abstract We attempt to formulate the simplest possible model mimicking turbulent dynamics, such as quasi-cyclic behaviour (QCB), using only three variables. To this end, we first conduct direct numerical simulations of three-dimensional flow driven by steady Taylor–Green forcing find a similarity between stable periodic orbit (SPO) at small Reynolds number (Re) and QCB higher Re. A close examination SPO allows heuristic formulation three-equation model, representing evolution Fourier modes...
This was a prospective study.This study aimed to investigate the accuracy of gutter position after cervical double-door laminoplasty (LP) using intraoperative computed tomography (CT) navigation and factors associated with C5 palsy.There were some reports in which width decompression LP palsy; however, there few about position.Thirty-three patients treated enrolled. We marked our targeted on lamina high-speed drill CT performed procedure. The evaluated postoperative scan. measured angle...