A5101639859- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Cardiac Arrhythmias and Treatments
- Hydrogen's biological and therapeutic effects
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Botulinum Toxin and Related Neurological Disorders
- Coronary Artery Anomalies
- Pharmacological Receptor Mechanisms and Effects
- Cardiac pacing and defibrillation studies
- Vascular anomalies and interventions
- Essential Oils and Antimicrobial Activity
- Ion channel regulation and function
- Gout, Hyperuricemia, Uric Acid
- Chemical Reactions and Isotopes
- Cardiovascular Function and Risk Factors
- Neuroscience and Neuropharmacology Research
- Kawasaki Disease and Coronary Complications
- Pharmacological Effects of Natural Compounds
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- Cardiovascular Issues in Pregnancy
Dokkyo Medical University Saitama Medical Center
2012-2023
Social Insurance Saitama Chuo Hospital
2020-2023
Kyushu University
2001-2022
Daiichi University of Pharmacy
2010-2022
Dokkyo Medical University
2011-2021
Duquesne University
2015-2016
Network Group (Czechia)
2016
Impact
2016
Komatsu (Japan)
2015
Vascular endothelial growth factor (VEGF) is a key mediator of tumor angiogenesis. Tumor cells are exposed to higher oxidative stress compared normal cells. Numerous reports have demonstrated that the intracellular redox (oxidation/reduction) state closely associated with pattern VEGF expression. Electrolyzed reduced water (ERW) produced near cathode during electrolysis scavenged H2O2 and decreased release from human lung adenocarcinoma cell line, A549, down-regulated both transcription...
Dementia is one of the most common causes disability worldwide characterized by memory loss, cognitive impairment, and behavioral psychological symptoms (BPSD), including agitation. Treatment latter consists off-label use harmful atypical antipsychotics, though a significant reduction afforded pain control. The an essential oil endowed with analgesic properties devoid toxicity would represent important option for management agitation in dementia. Therefore, aim this study was to engineer...
This study investigated the effect of bergamot essential oil (BEO) or linalool, a major volatile component BEO, on nociceptive response to formalin. Plantar subcutaneous injection BEO linalool into ipsilateral hindpaw reduced both first and late phases formalin-induced licking biting responses in mice. contralateral did not yield an antinociceptive effect, suggesting that formalin test occurred peripherally. Intraperitoneal plantar pretreatment with naloxone hydrochloride, opioid receptor...
Monocyte derived macrophages (MDMs) infiltrate sites of infection or injury and upregulate cyclooxygenase-2 (COX-2), an enzyme that stimulates prostaglandin-E2 (PgE2). Nanotheranostics combine therapeutic diagnostic agents into a single nanosystem. In previous studies, we demonstrated nanotheranostic strategy, based on theranostic nanoemulsions (NE) loaded with COX-2 inhibitor (celecoxib, CXB) equipped near-infrared fluorescent (NIRF) reporters, can specifically target circulating monocytes...
Background: Acute coronary syndrome (ACS), which is emerging in adults long after confirmed (followed-up or lost-to-follow), missed Kawasaki disease (KD), poorly characterized. Methods and Results: A Japanese retrospective nationwide hospital-based questionnaire survey of ACS during 2000-09 was conducted to characterize such patients. Among a total 67 patients (median age 35, male 76%) recruited, low conventional risks (≤1/6) noted 75%, diagnosis ST-elevation myocardial infarction cardiac...
Linalool is the principal component of many essential oils known to possess biological activities. We previously reported that intraplantar injection linalool reduces nociceptive response as assayed by capsaicin test. In this study, we sought determine whether could influence induction acute pain (allodynia and hyperalgesia) paclitaxel in mice. Paclitaxel widely used cancer chemotherapy for treatment solid tumors, but it sometimes induces moderate severe pain. administered intraperitoneally...
β-Caryophyllene (BCP) is known as a common constitute of the essential oils numerous food plants and primary component in Cannabis. In this study, we investigated effect local intraplantar (i.pl.) injection BCP on mechanical hypersensitivity induced by partial sciatic nerve ligation (PSNL) mice. Relative to sham operation controls, mice with PSNL displayed maximum level hyperresponsiveness von Frey metallic filament post-operative day 7. PSNL-induced allodynia was seen ipsilateral side...
Vincristine is an anticancer drug used to treat a variety of cancer types, but it frequently causes peripheral neuropathy. Neuropathic pain often associated with the appearance abnormal sensory signs, such as allodynia. Milnacipran and duloxetine, serotonin/noradrenaline reuptake inhibitors, have shown efficacy against several chronic syndromes. In this study, we investigated attenuation vincristine-induced mechanical allodynia in mice by milnacipran duloxetine. To induce neuropathy,...
Atrial low-voltage zones (LVZs) may be related to maintenance of atrial fibrillation (AF). The influence left (LA) contact areas (CoAs) on reentrant or rotor-like sources maintaining AF has not been investigated.Forty patients with persistent (PsAF) were analyzed. Three representative CoA regions in the LA (ascending aorta: anterior wall; descending inferior pulmonary vein; and vertebrae: posterior wall) visualized by enhanced CT. Using circular catheters, LVZs (<0.5 mV) assessed after...
Neuropathic pain is an intractable chronic condition that mainly caused by allodynia. We had previously reported intra-plantar administration of bergamot essential oil (BEO) containing aromatic compound significantly suppressed partial sciatic nerve ligation (PSNL)-induced mechanical allodynia via opioid mu receptors in mice. However, it has also been the inhalation BEO reduced formalin-induced nociceptive responses. Therefore, we aimed to elucidate whether analgesic action mediated...
Objective The aim of this study was to clarify the circadian and seasonal variations in addition identify sex-based differences Japanese patients with Takotsubo syndrome (TTS). Methods authors conducted a retrospective observational analyse between groups based on sex. Patients were registered out each institute registry acute coronary (ACS) which contains total 10,622 cases eight academic hospitals east Japan. Results Data for 344 consecutive TTS (73 male 271 female) extracted from hospital...
Insulin-producing cells express limited activities of anti-oxidative enzymes. Therefore, reactive oxygen species (ROS) produced in these play a crucial role cytotoxic effects. Furthermore, diabetes mellitus (DM) development is closely linked to higher ROS levels insulin-producing cells. Hita Tenryosui Water® (Hita T. W., Hita, Japan) and Nordenau water (Nord. Nordenau, Germany), referred as natural reduced waters (NRWs), scavenge cultured cells, therefore, might be possibility an alternative...