A5004350112- Organ and Tissue Transplantation Research
- Reconstructive Surgery and Microvascular Techniques
- Reconstructive Facial Surgery Techniques
- Cleft Lip and Palate Research
- Organ Donation and Transplantation
- Craniofacial Disorders and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Ocular Disorders and Treatments
- Orthopedic Surgery and Rehabilitation
- Nerve injury and regeneration
- Tissue Engineering and Regenerative Medicine
- Facial Trauma and Fracture Management
- Bone fractures and treatments
- Burn Injury Management and Outcomes
- Traumatic Ocular and Foreign Body Injuries
- Nasal Surgery and Airway Studies
- Genital Health and Disease
- Biomedical Ethics and Regulation
- Surgical Sutures and Adhesives
- Nerve Injury and Rehabilitation
- Social Robot Interaction and HRI
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Transplantation: Methods and Outcomes
- Nonmelanoma Skin Cancer Studies
Wake Forest University
2018-2025
Indiana University – Purdue University Indianapolis
2023-2025
Amrita Institute of Medical Sciences and Research Centre
2025
Indiana University School of Medicine
2025
Turkish Armed Forces
2011-2023
Forest Institute
2018-2023
Atrium Health Wake Forest Baptist
2023
Cleveland Clinic
2009-2020
Antalya IVF
2020
Duquesne University
2018-2019
Adipose tissue engineering is a promising field for regeneration of soft defects. However, vascularization needed since nutrients and oxygen cannot reach cells in thick implants by diffusion. Obtaining biocompatible scaffold with good mechanical properties another problem. In this study, we aimed to develop vascularized adipose constructs supporting cell viability regeneration. Hydrogels were prepared mixing rat decellularized (DAT) silk fibroin (Fib) at different v/v ratios (3:1, 1:1 1:3)...
Functional nerve regeneration after reconstructive surgery remains unsatisfying. In this study, vascular endothelial growth factor (VEGF) gene therapy combined with a hyaluronic acid (HA)-enriched microenvironment in was investigated. Sciatic transected, and end-to-end neurorrhaphy performed on 32 male Sprague-Dawley rats, which were randomly divided into four groups (n = 8 per group): coaptation without treatment (group I); covered HA film sheath II); intramuscular VEGF plasmid injection...
Monocyte derived macrophages (MDMs) infiltrate sites of infection or injury and upregulate cyclooxygenase-2 (COX-2), an enzyme that stimulates prostaglandin-E2 (PgE2). Nanotheranostics combine therapeutic diagnostic agents into a single nanosystem. In previous studies, we demonstrated nanotheranostic strategy, based on theranostic nanoemulsions (NE) loaded with COX-2 inhibitor (celecoxib, CXB) equipped near-infrared fluorescent (NIRF) reporters, can specifically target circulating monocytes...
Abstract The field of vascularized composite allotransplantation (VCA) is the new frontier solid organ transplantation (SOT). VCA spans life-enhancing/life-changing procedures such as upper extremity, craniofacial (including eye), laryngeal, tracheal, abdominal wall, penis, and lower extremity transplants. VCAs uterus transplants are life giving unlike any other SOT. Of all that have shown successful intermediate- to long-term graft survival with functional immunologic outcomes, remained...
In inflammatory diseases or following an injury, dysregulated inflammation is a common driver of pain and tissue damage. Macrophages are immune cells that contribute to the initiation, maintenance, resolution due their phenotypic plasticity in response signals from microenvironments. infiltrate polarize toward pro-inflammatory phenotype (M1-like), thereby increasing severity inflammation. Therefore, we aimed suppress activity M1-like macrophages decrease infiltration at site insult resolve...
Microsurgical operations of the hand are common procedures reconstructive surgeons. Sympathetic blockade vessels provides increased blood flow to injured extremity, which increases success rate surgery. Moreover, postoperative pain management can be performed with continuous nerves. In this article, effect brachial plexus on patients who underwent upper extremity microsurgical operation was evaluated.A total 16 were operated either for replantation or toe-to-hand transfer. The first group (n...
Peripheral nerve injuries (PNIs) can be most disabling, resulting in the loss of sensitivity, motor function and autonomic control involved anatomical segment. Although injured peripheral nerves are capable regeneration, sub-optimal recovery is seen even with best reconstruction. Distal axonal degeneration an unavoidable consequence PNI. There currently few strategies aimed to maintain distal pathway and/or target fidelity during regeneration across zone injury. The current state art...
Abstract Cellular and vascularized bone marrow cells have been used to induce donor‐specific chimerism in various models of composite tissue allotransplantation. Although thymus transplantation has reported the literature, effect on levels containing allotransplantation not reported. In this study, a new method for sternal transplant model is descried that can be applied augment after transplantation. A total seven osseomusculocutaneous sternum, ribs, thymus, pectoralis muscles, skin...
Bioactive peptide gels enhance the regeneration of peripheral nerve injuries, which affect 20 million patients in USA.
Transport distraction technique is a good treatment modality for unilateral temporomandibular joint ankylosis. However, with unidirectional distraction, it not possible to correct facial asymmetry that results from mandibular hypoplasia associated early-onset For this purpose, gap arthroplasty and simultaneous bidirectional transport was used these deformities. Although vertical corrects deficiency of the ramus creates neocondyle, anteroposterior segment resulting horizontal shortness...
This case describes a 2-year-old boy who developed multiple giant pyogenic granulomas on his left upper extremity secondary to burn injury caused by boiling milk. Here, we present in patient and discuss the possible etiologies of entity. The were excised wounds closed with sutures (primary repair) closure). No have recurred after 11 months follow-up. Pyogenic granuloma dissemination scar is an extremely rare occurrence, there been no reports flame other type scalding burns such as hot water...
Liquefied petroleum gas (LPG), which is used as a type of fuel, stored liquid under high pressure in tanks. Immediate and sudden explosion these tanks can release large amount energy into the environment result serious burns. In this study, cases 18 patients injured due to LPG burns five incidents were examined, along with their epidemiologic features. The authors also investigated causes tank explosions. Inhalation injury was present 11 varying degrees severity, 7 subsequently required...
Snakebites are common among the rural population of developing countries. The severity venomous snakebites depends on several factors, including location bite, amount venom injected, and effectiveness initial therapy. frequently occur in extremities with approximately two thirds envenomations occurring upper extremities. In this study, we presented 12 cases hand reconstruction after Vipera discussed how to minimize functional loss maximize rehabilitation. Twelve patients bitten by between...
This study aimed to evaluate the osteometric boundaries of ilium, fibula, and scapula beyond which reconstruction oromandibular craniofacial defects, using these free flaps, may not be optimal. Fibula, scapula, iliac bones were obtained bilaterally from 33 female 27 male European adult cadavers (n = 60). Adapting classical anthropometric methods surgical needs by modifying measuring bone localizations measurement points, a system osteometry morphometry was used, quantify usable length crest,...