A5104053082- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Stress Responses and Cortisol
- Cardiac tumors and thrombi
- Radiation Therapy and Dosimetry
- Advanced materials and composites
- Acute Ischemic Stroke Management
- Treatment of Major Depression
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Semiconductor Lasers and Optical Devices
- Plant Genetic and Mutation Studies
- Transcranial Magnetic Stimulation Studies
- Engineering Applied Research
- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer therapeutics and mechanisms
- Galectins and Cancer Biology
- Optical Network Technologies
- Bladder and Urothelial Cancer Treatments
- Atomic and Subatomic Physics Research
- Parkinson's Disease and Spinal Disorders
- Aortic aneurysm repair treatments
Tokyo Medical University
2016-2025
Kurashiki Medical Center
2025
Shiga Medical Center
2024
National Archives and Records Administration
2022-2024
Nara Prefecture General Medical Center
2022-2024
Asahi General Hospital
2022-2024
Osaka City General Hospital
2001-2024
Hospital for Sick Children
2022-2023
Nara Medical University
2023
Katsushika Medical Center
2023
Dorsal striatum, principally comprising of caudate and putamen, is well-known to support motor function but also various higher-order cognitive functions. This enabled by developing short- long-range connections distributed cortical regions throughout the life span, few studies have examined developmental changes from young children adults in same cohort. Here we investigated development dorsal-striatal network a large (n = 476), single-site sample healthy subjects 3–42 years age three...
Objective This study aims to assess the predictive accuracy and clinical utility of Collaborative Respiratory Assessment Score (CoRAS) in identifying pneumonia risk among stroke patients Kaifukuki Rehabilitation Wards (KRWs). CoRAS, developed by a multidisciplinary team, incorporates eight parameters quantify respiratory risk. The retrospectively applies CoRAS cohort evaluates its performance using statistical methods, including logistic regression receiver operating characteristic (ROC)...
To elucidate the differences in associated factors beyond bipolarity between Benazzi's depressive mixed state (DMX), defined as a major episode (MDE) with ≥ 3 manic/hypomanic symptoms, and Diagnostic Statistical Manual of Mental Disorders fifth edition criteria for features (DSM-5-DMX), an MDE non-overlapping symptoms. The associations DMX definitions bipolarity, anxious distress (ANXD), autism spectrum disorder, attention-deficit hyperactivity older age were retrospectively examined 160...
The treatment landscape for advanced, unresectable, or metastatic urothelial carcinoma (aUC) has shifted substantially since the advent of immune checkpoint inhibitors (ICIs). We investigated extent to which pembrolizumab therapy is superior conventional chemotherapy as a second-line treatment.A multicenter-derived database registered 454 patients diagnosed with aUC between 2008 and 2020. Of these, 94 (21%) who received 75 (17%) but never third-line later ICI were included. compared overall...
Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a life‐threatening complication post‐acute embolism (PE). The assessment of CTEPH incidence and risk factors PE in the era direct oral anticoagulants remains insufficient. Methods Results COMMAND VTE Registry‐2 (contemporary management outcomes patients with venous thromboembolism registry‐2) multicenter registry that recruited consecutive acute symptomatic from 31 centers across Japan. primary outcome was to demonstrate...
The doping control analyses at the XXXII Olympic Games (July 23 to August 8, 2021) and XVI Paralympic (August 24 September 5, held in Tokyo, Japan, after a year of delay due COVID-19 pandemic are summarized this paper. A new satellite facility existing World Anti-Doping Agency (WADA)-accredited Tokyo laboratory was established fully operated by 278 staff, including 33 49 international experts, 196 Japanese temporary staff. numbers urine samples were 5081 (Olympics) 1519 (Paralympics), blood...
Abstract Background Falciform ligament abscess (FLA) is a rare disease, and its diagnosis can be challenging without typical image findings of an abscess. We report patient with FLA that presented as mass, indistinct border between it the liver, in addition to disseminated foci within liver. This made difficult determine whether was or malignancy. Case presentation A 69-year-old man epigastric pain. Contrast-enhanced computed tomography revealed 25-mm mass below middle diaphragm. Based on...
The comprehensive behavioral intervention for tics (CBIT) is the first-line psychotherapeutic treatment individuals with tic disorders. However, most patients disorders do not have access to CBIT due different factors including lack of trained therapists, cost, and travel distance. Such barriers are more prominent in non-English speaking countries. Therefore, current study assessed preliminary efficacy, feasibility, acceptability remotely administered group (RG-CBIT) Japan.This was an...
The constituents of 13 species bamboos and bamboo grasses were investigated. Almost all the gave isoorientin related flavone 6-C-glycosides as major leaves. Tricin 5-O-β-D-glucopyranoside p-coumaric acid also obtained minor ones in some cases. (-)-Lyoniresinol 3a-O-β-D-glucopyranoside (+)-lyoniresinol common culms 4 examined. 3, 4, 5-Trimethoxyphenol β-D-glucopyranoside, koaburaside, 2, 6-dimethoxy-p-benzoquinone, acid, sinapic aldehyde ferulyl occurred sporadically. Arbutin was a constituent roots
Background: Mirtazapine, a noradrenergic and specific serotonergic antidepressant, which blocks the α 2 -adrenergic autoreceptors heteroreceptors, has shown anxiolytic properties in clinical trials preclinical animal experiments. The addition of mirtazapine to selective serotonin reuptake inhibitors (SSRIs) is clinically suggested be more effective for anxiety disorders. In this study, we examined combined effects citalopram, an SSRI, on freezing behavior rats, was induced by contextual...
The increase in the number of patients with type 2 diabetes mellitus is an important concern worldwide. goal this study was to investigate factors involved onset mellitus, and sex differences long-term follow up people normal glucose tolerance.Of 1,309 individuals who underwent screening at our facility 2004, 748 without were enrolled. Correlations metabolic markers including serum adiponectin (APN) examined over 15 years these individuals.The Kaplan-Meier curve for decreased APN group...
Background: The bipolar-unipolar distinction in patients with a major depressive episode is the most important issue related to diagnosis and treatment of mood disorders, but remains unresolved. This study was undertaken compare bipolar unipolar depression on Rorschach testing using Comprehensive System reference healthy Japanese controls. Methods: Patients or who had undergone test for routine clinical purposes were followed up naturalistically long period. Based diagnostic confirmation...
Chronic kidney disease (CKD) is a very important issue globally because of the risk its progressing to end-stage renal disease. We aimed identify factors contributing long-term estimated glomerular filtration rate (eGFR) decline determine an early diagnosis and prevent CKD progression.
Purpose To delineate the characteristics of probable antibody-negative pediatric autoimmune encephalitis (probable Ab-negative AE), we compared clinical features AE to those major antibody-positive AE. Methods We retrospectively reviewed 18 patients with AE, 13 anti-N-methyl-D-aspartate receptor (NMDARE), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Clinical characteristics, neuroimaging findings, treatments, outcomes were analyzed. Results The age onset...
The simplified Pulmonary Embolism Severity Index (sPESI) score could help identify low-risk patients with pulmonary embolism for home treatment. However, the application of sPESI and selection treatment have not been fully evaluated in direct oral anticoagulants era.
Ischemic stroke is a serious complication in patients with cancer-associated venous thromboembolism (CAVTE), although data remain scarce the direct oral anticoagulant era.
Previous randomized clinical trials did not support a benefit of screening for occult cancer after diagnosis venous thromboembolism (VTE), although may be potential selected high-risk patients.
(Purpose) We performed a clinical retrospective study on the evaluation of pembrolizumab treatment results for advanced urothelial cancer in our hospital. (Materials and Methods) Twenty-seven patients diagnosed with or metastatic carcinoma who received between April 2018 December 2021 were included. retrospectively reviewed medical records to examine outcomes, immune-related adverse event (irAE), prognostic factors. (Results) The median age was 76 years, number doses 6. overall survival 8.8...