A5102743259- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Thin-Film Transistor Technologies
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Pediatric Hepatobiliary Diseases and Treatments
- CCD and CMOS Imaging Sensors
- Semiconductor materials and devices
- Quasicrystal Structures and Properties
- Advanced Memory and Neural Computing
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet, Metabolism, and Disease
- Hepatitis C virus research
- Phytoestrogen effects and research
- Photonic and Optical Devices
- Systemic Lupus Erythematosus Research
- Autoimmune Neurological Disorders and Treatments
- Intermetallics and Advanced Alloy Properties
- High-Velocity Impact and Material Behavior
- HIV-related health complications and treatments
- Cytomegalovirus and herpesvirus research
- Microstructure and mechanical properties
- Computational Fluid Dynamics and Aerodynamics
- Hepatitis B Virus Studies
- Gastrointestinal disorders and treatments
Fukushima Medical University
2015-2024
Semiconductor Energy Laboratory (Japan)
2004-2024
Hirosaki University Hospital
2022-2024
Osaka International Cancer Institute
2023
Weatherford College
2022
Tochigi Medical Center
2022
Honda (Japan)
2003-2020
University Gastroenterology
2020
The gut microbiota has recently been recognized to play a role in the pathogenesis of autoimmune liver disease (AILD), mainly primary biliary cholangitis (PBC) and hepatitis (AIH). This study aimed analyze compare composition oral 56 patients with AILD 15 healthy controls (HCs) evaluate its association salivary immunological biomarkers microbiota. subjects included 39 PBC 17 AIH diagnosed at our hospital. control population comprised matched HCs. Salivary fecal samples were collected for...
BACKGROUND: The optimal duration of anticoagulation therapy for isolated distal deep vein thrombosis in patients with cancer is clinically relevant, but the evidence lacking. prolonged could have a potential benefit prevention thrombotic events; however, it also increase risk bleeding. METHODS: In multicenter, open-label, adjudicator-blinded, randomized clinical trial at 60 institutions Japan, we randomly assigned thrombosis, 1-to-1 ratio, to receive either 12-month or 3-month edoxaban...
Aim Sarcopenia has a negative impact on the prognosis of patients with hepatocellular carcinoma (HCC). We investigated significance skeletal muscle volume and its changes in HCC receiving transarterial chemoembolization (TACE). Methods retrospectively analyzed 179 TACE from 2006 to 2017. Skeletal mass index was calculated as left–right sum major × minor axis psoas at third lumbar vertebra, divided by height squared (psoas [PMI]). Patients were classified into two groups (low normal PMI)...
Abstract This study developed an organic light‐emitting diode display featuring c‐axis‐aligned crystalline oxide semiconductor (CAAC‐OS) field‐effect transistors (FETs) monolithically stacked over silicon (Si) FETs. achieved a definition of 5,009 ppi and luminance 10,000 cd/m 2 . Below the pixels incorporating CAAC‐OS FETs, both source scan drivers central processing unit (CPU; Cortex‐M0) were integrated using Si FETs without widening bezel. The findings indicate that built‐in CPU enables...
In this study, we proposed scalable trench-gate-self-aligned (TGSA) c-axis aligned crystalline In-Ga-Zn-Oxide field effect transistors (CAAC-IGZO FETs) formed by only three masks. We demonstrated that the 20-nm-node FETs with 11-nm-EOT exhibit good short-channel properties, high frequency, and low off-state current. The TGSA can be candidates for key devices to realize super power large-scale integration technology such as Internet of Things.
Sarcopenia and osteoporosis are important complications in chronic liver disease (CLD). The aim of this study was to investigate the relationship between sarcopenia patients with CLD.We retrospectively investigated 112 CLD (57 men 55 women), including 40 cirrhotic (36%), by measuring appendicular skeletal muscle mass index (ASMI) using bio-impedance analysis. Bone mineral density (BMD) measured dual-energy X-ray absorptiometry.The rate 13% (14/112), osteopenia rates were 17% (19/112) 65%...
The present study aimed to investigate the incidence of hepatocellular carcinoma (HCC) and factors related HCC occurrence after direct-acting antiviral (DAA) treatment in Fukushima Liver Academic Group (FLAG). We conducted a multicenter retrospective cohort 1068 patients without cirrhosis (NC) or with compensated liver (LC) who achieved sustained virologic response (SVR). First, we compared cumulative survival rates NC (n = 880) LC 188) history treatment. Second, performed multivariate...
Patients with non-alcoholic fatty liver disease (NAFLD) have impaired health-related quality of life including physical and mental state. Near-infrared spectroscopy (NIRS) is a useful tool for evaluation brain activity depressive This study aimed to determine the female NAFLD patients using NIRS. Cerebral oxygenated hemoglobin (oxy-Hb) concentration during verbal fluency task (VFT) was measured NIRS in 24 15 healthy controls. The Center Epidemiologic Studies Depression Scale (CES-D)...
Abstract Sarcopenia is associated with poor prognosis of patients hepatocellular carcinoma (HCC). We investigated the association skeletal muscle volume (SMV) and its change in HCC taking lenvatinib. In 130 patients, psoas mass index (PMI) was calculated as left–right sum major × minor axis at third lumbar vertebra, divided by height squared. Patients were classified into two groups (low normal PMI) based on indices < 6.0 cm 2 /m for man 3.4 women. Change PMI per month during lenvatinib...
Background The effects of sleep quality on the risk developing non-alcoholic fatty liver disease (NAFLD) remain uncertain. purpose this study was to clarify association between and NAFLD. Methods data 4828 participants who underwent health check-ups at four hospitals were analysed. Sleep evaluated by Pittsburgh Quality Index (PSQI), which comprised seven elements scored from 0 3. global PSQI score for each element compared NAFLD non-NAFLD groups separately sex. Logistic regression analysis...
Endpoint artificial intelligence (Al) requires high flexibility in Al processes under strict cost and power limitations. This work aims to achieve a chip capable of executing at low while periodically switching the context multiple neural networks (NNs) small area. Transistors fabricated using crystalline oxide semiconductor (OS) such as indium-gallium-zinc exhibit an extremely offstate current. Such transistors have compatibility with Si CMOS OS transistor layers can be stacked [1]. A...
Objective Hyponatremia is closely associated with the pathophysiology of cirrhosis. However, association between serum sodium level and response to tolvaptan unclear. This study evaluated factors related prognosis in cirrhosis patients ascites hyponatremia. Methods We retrospectively reviewed clinical records hospitalized for treatment tolvaptan. The associations patient baseline characteristics after one week one-month were analyzed. Results analyzed 83 ascites, including 34 rates <130...
Abstract The low‐power display technology of liquid crystal (LCD) including crystalline IGZO by variable frame frequency has been previously reported. Application the to controller and processor unit as well LCD driver(s) proposes a method for saving power whole system.
We report 2 cases of endogenous endophthalmitis associated with pyogenic liver abscess caused by Klebsiella pneumoniae. Case 1 involved a 70-year-old woman and case 50-year-old man who were admitted to our hospital diagnoses endophthalmitis, respectively. The resolved antibiotics percutaneous transhepatic drainage in alone 2. Even though both underwent ophthalmic surgery, they discharged from without the recovery their eyesight. An earlier diagnosis treatment are needed improve prognosis...
Autoimmune hepatitis (AIH) is an immune disorder characterized by hypergammaglobulinemia, autoantibodies, and chronic active on liver histology. However, cell population characteristics in AIH patients remain poorly understood. This study was designed to analyze peripheral blood mononuclear (PBMC) through single-cell RNA sequencing (scRNA-seq) explore potential AIH-related molecular mechanisms. We generated 3690 3511 transcriptomes of PBMCs pooled from 4 healthy controls (HCs) patients,...
Objective A short sleep duration is associated with non-alcoholic fatty liver disease (NAFLD). However, the causal relationship between a and onset of NAFLD remains unknown because lack any longitudinal studies. Therefore, we evaluated association NAFLD. Methods We health checkup data for 1,862 NAFLD-free Japanese adults aged 33-86 years at baseline followed those individuals median 41 months. Hepatic steatosis was examined using ultrasonography (US). The Cox proportional hazards model used...
A CPU using a high performance poly-silicon TFT is successfully fabricated on plastic film substrate by transfer technology onto we developed. No degradation the process was observed, and confirmed operation at frequency of more than 10MHz with power source voltage 33V.
25-Hydroxyvitamin D [25(OH)D] has been reported to be associated with several chronic liver diseases. The relationship between 25(OH)D and autoimmune hepatitis (AIH) pathogenesis is incompletely understood. We investigated the association of serum total free levels necroinflammatory activity cytokine in 66 patients AIH diagnosed our hospital. median age at diagnosis was 57 years, male:female ratio 7:59. level therapy-naïve 14.2 ng/mL (interquartile range [IQR], 11.4–17.9 ng/mL). Of AIH, 36...
Equol, which is an active metabolite of isoflavone, has a beneficial impact on metabolic diseases such as dyslipidemia and hyperglycemia. However, the effect equol obesity remains uncertain. This study was performed to determine association between in postmenopausal women.We evaluated 386 women their 50s-60s who underwent health check-ups from February 2018 January 2019 at Watari Hospital Health Center Fukushima, Japan. Overweight visceral were defined body mass index ≥25 kg/m2 waist...
Abstract Aseptic meningitis sometimes occurs as a consequence of central nervous system (CNS) involvement in patients with primary Sjögren’s syndrome (SS), even paediatric-onset cases. However, little information is available regarding the pathological role CSF anti-Ro/SSA and anti-La/SSB antibodies CNS SS. We experienced an 18-year-old adolescent female 7-year history suspicion subclinical SS who subsequently developed aseptic initial presentation probable Her exhibited marked elevation...
On the basis of fabrication a CPU on glass as digital circuit presented in B. Lee et al. (2003) and T. Ikeda (2004), well flexible using TFT transfer technology Takayama we have succeeded development world's first RFCPUs (8bit, passive type) by adding to an antenna, analog circuit, encryption function RFID function, which operate RF signal with frequency 13.56MHz
A non-invasive biomarker for patients with primary biliary cholangitis (PBC) is needed. The association between leucine-rich α2 glycoprotein (LRG) and PBC has not been investigated. We aimed to assess the predictive value of LRG development cirrhosis-related conditions in PBC.We retrospectively reviewed clinical data 129 individuals biopsy-confirmed PBC. Leucine-rich was analyzed by enzyme-linked immunosorbent assays using stored sera at biopsy (n = 129) after treatment 80).Levels decreased...
We have prototyped a microcontroller (MCU) that employs crystalline In-Ga-Zn oxide transistors having an extremely low off current below 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-21</sup> A. The IGZO-based MCU can retain data during power gating in both of its processing unit and memory, there is integrated voltage regulator store the reference voltage. with combination 60-nm IGZO (in BEOL) 110-nm Si CMOS processes. It has standby 880...