A5065250946- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- MicroRNA in disease regulation
- Liver physiology and pathology
- Extracellular vesicles in disease
- Child Nutrition and Feeding Issues
- Eating Disorders and Behaviors
- Animal Genetics and Reproduction
- Drug Transport and Resistance Mechanisms
- Cancer Research and Treatments
- Phagocytosis and Immune Regulation
- Cancer Mechanisms and Therapy
- Endoplasmic Reticulum Stress and Disease
- Alcoholism and Thiamine Deficiency
- Nutrition and Health in Aging
- Vascular anomalies and interventions
- Bone and Dental Protein Studies
- Abdominal vascular conditions and treatments
Yamagata University
2014-2025
Yamagata University Hospital
2022
Mayo Clinic in Arizona
2020-2021
Japan Agency for Medical Research and Development
2021
Mayo Clinic
2019-2020
WinnMed
2020
Institute of Neurobiology
2020
There is limited information regarding the benefits of Lenvatinib-transcatheter arterial chemoembolization (LEN-TACE) sequential therapy for unresectable hepatocellular carcinoma (u-HCC). We compared efficacy and safety LEN-TACE to LEN monotherapy investigated factors contributing deep response.We enrolled a multicenter cohort 247 patients with u-HCC treated between 2018 2020. Propensity score matching identified 63 pairs well-balanced characteristics. retrospectively clinical outcomes,...
Abstract Objectives While esophageal varices (EVs) are typically treated endoscopically, other options such as interventional radiology or surgical treatment considered when endoscopic is challenging. Pipeline EVs difficult to treat endoscopically due their large diameter, and currently, no specific guidelines have been established. Methods We reviewed cases of pipeline at our hospital analyzed previously reported collect evidence for the formulation guidelines. Additionally, we created EV...
Milax gagates, native to the western Mediterranean region, has been introduced many countries including Japan. Despite need for an anatomical examination its accurate identification, records of this species in Japan have based on brief lists 20th century and recent distribution remains unclear. In study, we rediscovered slugs M. gagates from Tokyo, Japan, identified them by examining traits a mitochondrial cytochrome c oxidase subunit I (COI) haplotype. This is believed be established study...
In recent years, the development of diagnostics using artificial intelligence (AI) has been remarkable. AI algorithms can go beyond human reasoning and build diagnostic models from a number complex combinations. Using next-generation sequencing technology, we identified hepatitis C virus (HCV) variants resistant to directing-acting antivirals (DAA) by whole genome full-length HCV genomes, applied these various machine-learning evaluate preliminary predictive model. genomic RNA was extracted...
Our research elucidated that the composition of basolateral EVs from biliary epithelial cells changed under bile acid exposure and contained novel inflammation-inducing proteins NPM, NCL, MK fibrosis-inducing protein LECT2. We report these new results are possible to lead potential therapeutic target cholestatic liver diseases in future.
The number of Japanese patients with anorexia nervosa (AN) is increasing as society changes. Mild liver injury a complication AN in around 30% cases. In some rare instances, present severe similar to acute failure. However, there are numerous uncertainties over the clinical characteristics this condition. objective study was clarify complicated by and investigate factors related hepatic complications.Thirty-seven hospitalized at our institution diagnosis were enrolled subjects. used data...
In cholestatic liver diseases, ductular reactive (DR) cells extend into the hepatic parenchyma and promote inflammation fibrosis. We have previously observed that multidrug-resistant 2 (Mdr2-/- ) double knockout (DKO) mice lacking tumor necrosis factor-related apoptosis-inducing ligand receptor (Tr-/- display a more extensive reaction fibrosis compared to Mdr2-/- mice. This observation suggests magnitude of DR-cell population may be regulated by apoptosis.To examine this concept, we cultured...
Abstract Sarcopenia is associated with poor prognosis of patients hepatocellular carcinoma (HCC). We investigated the association skeletal muscle volume (SMV) and its change in HCC taking lenvatinib. In 130 patients, psoas mass index (PMI) was calculated as left–right sum major × minor axis at third lumbar vertebra, divided by height squared. Patients were classified into two groups (low normal PMI) based on indices < 6.0 cm 2 /m for man 3.4 women. Change PMI per month during lenvatinib...
In mouse models of biliary tract diseases, macrophages are recruited to the periductal milieu and promote injury cholestasis. Although cell necrosis with release biomolecules termed damage-associated molecular patterns (DAMPs) promotes recruitment activation macrophages, was not observed in these studies. Because extracellular vesicles (EVs) important cell-to-cell communication, we postulated that activated cholangiocytes may EVs containing DAMPs as cargo. Both human (NHC) cholangiocyte...
We have previously reported that epiregulin is a growth factor seems to act on liver progenitor cells (LPCs) during regeneration. However, the relationship between and LPCs has remained unclear. The aim of present study was clarify role serum levels in patients with acute failure were examined. A injury model developed using mice fed diet containing 0.1% 3.5-diethoxycarbonyl-1.4-dihydrocollidine (DDC) induce LPCs. then evaluated expression these mice. proliferation epithelial cell adhesion...
AIM:To clarify the characteristics of metabolite profiles in virus-related hepatocellular carcinoma (HCC) patients using serum metabolome analysis. METHODS:The levels low-molecular-weight metabolites 68 with HCC were quantified capillary electrophoresis chromatography and mass spectrometry.Thirty 38 suffered from hepatitis B (HCC-B) C (HCC-C), respectively. RESULTS:The main characteristic those associated glutathione metabolism, notably 13 γ-glutamyl peptides, which are by-products...
Multiple factors are involved in the pathogenesis of primary biliary cholangitis (PBC), a chronic cholestatic liver disease, characterized by intrahepatic cholangiopathy. In particular, studies have suggested that environmental such as presence granulomas portal vein region important for development PBC. This study aimed to comprehensively analyze and identify foreign-derived antigens PBC tissue confirm their involvement pathogenesis.
Hepatic steatosis is often seen in patients with chronic hepatitis C (CH-C). It still unclear whether these have an impaired mitochondrial β-oxidation. In this study we assessed β-oxidation CH-C by investigating ketogenesis during fasting. This consisted of thirty CH-C. Serum levels insulin and virus (HCV) core protein were measured chemiluminescence enzyme immunoassay. The subjects then fasted, venous blood samples drawn 12 h 15 after the start ketone bodies enzymatic cycling method. rate...
Abstract Hepatitis B virus (HBV) genotypes (HBV/B) and C (HBV/C) are the most prevalent among Japanese patients with hepatitis. Reportedly, HBV/C infection has been associated more severe disease progression, manifesting as developing cirrhosis hepatocellular carcinoma (HCC), than HBV/B infection. However, no long‐term studies have examined development of HCC in HBV/B‐infected Japan. The aims our study were to compare incidence HBV/B‐ or HBV/C‐infected patients. A total 241 followed up 295...
Autonomic nerve fibers in the liver are distributed along portal tract, being involved regulation of blood flow, bile secretion and hepatic metabolism, thus contributing to systemic homeostasis. The present study investigated changes biopsy specimens from patients with normal liver, viral hepatitis non-alcoholic steatohepatitis, relation clinical background. areal ratio total area was automatically calculated for each sample. fiber ratios (NFAR) sympathetic were significantly lower affected...
Alcohol-associated liver disease (ALD) has been recognized as the most common cause of advanced worldwide, though mechanisms pathogenesis remain incompletely understood. The X-linked inhibitor apoptosis (XIAP) protein was originally described an anti-apoptotic that directly binds and inhibits caspases-3, 7, 9. Here, we investigated function XIAP in hepatocytes vitro using gain loss-of-function approaches. We noted XIAP-dependent increase caspase activation well increased inflammatory markers...