A5084897854- Liver Disease Diagnosis and Treatment
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Evolutionary Psychology and Human Behavior
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Liver physiology and pathology
- Advanced biosensing and bioanalysis techniques
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Peptidase Inhibition and Analysis
- Tryptophan and brain disorders
- Advanced Multi-Objective Optimization Algorithms
- Liver Diseases and Immunity
- Metaheuristic Optimization Algorithms Research
- Birth, Development, and Health
- Neurotransmitter Receptor Influence on Behavior
- vaccines and immunoinformatics approaches
- Chronic Lymphocytic Leukemia Research
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Immune cells in cancer
Gansu Agricultural University
2024-2025
Shanghai Jiao Tong University
2020-2024
Guangzhou Medical University
2024
Jilin University
2017-2024
Jinzhou Medical University
2024
Mayo Clinic
2017-2024
WinnMed
2017-2024
Shanghai First People's Hospital
2024
Zhejiang University of Technology
2024
Jilin Province Science and Technology Department
2023
The functional status of innate immune cells is a considerable determinant effective antitumor response. However, the triple-negative breast cancer tumor microenvironment with high lactic acid metabolism and antioxidant levels limits cell survival, differentiation, function. Here, we determine that microenvironment-responsive nano-ultrasonic contrast agent Pt(IV)/CQ/PFH NPs-DPPA-1 boosts ratio mature dendritic (mDCs) proinflammatory macrophages by reprogramming immature DCs (iDCs)...
Monocyte homing to the liver and adhesion sinusoidal endothelial cells (LSECs) are key elements in nonalcoholic steatohepatitis (NASH) pathogenesis. We reported previously that VCAM-1 mediates monocyte LSECs. However, pathogenic role of NASH is unclear. Herein, we report was a top upregulated molecule mouse transcriptome. Open chromatin landscape profiling combined with genome-wide transcriptome analysis showed robust transcriptional upregulation LSEC murine NASH. Moreover, expression...
Background During liver injury, sinusoidal endothelial cells (LSECs) dysfunction and capillarization promote fibrosis. We have previously reported that the LSEC vascular cell adhesion molecule 1 (VCAM1) plays a key role in inflammation nonalcoholic steatohepatitis (NASH) we now aim to uncover its Methods Wild-type C57BL/6J mice were fed either chow or high fat, fructose cholesterol diet induce NASH treated with anti-VCAM1 neutralizing antibody control isotype antibody. Inducible...
Early adverse experiences often have devastating consequences. However, whether preweaning paternal deprivation (PD) affects emotional and social behaviors their underlying neural mechanisms remain unexplored. Using monogamous mandarin voles, we found that PD increased anxiety-like behavior attenuated preference in adulthood. also decreased the number of oxytocin (OT)-positive neurons projecting from paraventricular nucleus (PVN) reduced levels medial prefrontal cortex OT receptor protein...
Summary Tertiary lymphoid structure (TLS) provides a local and critical microenvironment for both cellular humoral immunity supports effective antigen presentation lymphocyte activation. However, the gene expression profile prognostic significance of TLS in oral cancer remain largely unrevealed. In this study, we found presence intratumoral peritumoral TLSs series 65 patients with treated by surgical resection, positive detection rates 33.8 75.4%, respectively. The TLSs, but not was...
Abstract Cancer vaccines are promising to treat malignancy by delivering antigens and adjuvants elicit host immunity. Beyond aluminum adjuvants, liposomes show efficient adjuvant effects through regulating the accumulation, internalization release of payloads. However, it remains unknown that whether liposome will perform intrinsic in absence adjuvants. Herein, a library antigen/adjuvant‐free with variable surface charges has been developed found highly anionic for boosting immune responses....
Introduction Listeria monocytogenes causes zoonotic listeriosis with a high mortality rate, which is frequently detected in slaughterhouse processing environments and animal-based food. To enable the specific, rapid, cost-effective detection of L. food, we developed double-antibody sandwich quantitative ELISA (DAS-qELISA) method. Methods The method based on monoclonal antibodies targeting internalin G (InlG), surface protein demonstrated immunogenicity. antibody pair 1D2-2H10 was selected...
The tumor microenvironment (TME) provides necessary nutrition for growth and recruits immunosuppressive factors including regulatory T cells myeloid-derived suppressor (MDSCs) to inhibit the anti-tumor immune response induced by immunotherapy. As a main TME component, cancer associated fibroblasts (CAFs) can restrain cell infiltration activity through extracellular matrix remodeling. Vaccines targeting fibroblast-activating protein α (FAPα), which is mainly expressed on CAF surface,...
Drug resistance becomes a formidable challenge against effective cancer therapy. Defective apoptosis in cells is key factor responsible for chemoresistance or radioresistance. Promoting an important method to sensitize the resistant cells, thereby achieving successful treatment MDR cancer. We present strategy of codelivery apoptotic AVPI peptide and p53 DNA as apoptosis-induction adjuvant therapy combating breast tetrapeptide poorly cell-permeable, with very limited value therapeutic use....
With the increase in obesity worldwide, its associated comorbidities, including nonalcoholic steatohepatitis (NASH), have become a public health problem that still lacks effective therapy. We previously reported mixed-lineage kinase 3-deficient (MLK3-deficient) mice are protected against diet-induced NASH. Given critical need to identify new therapeutic agents, we sought examine whether small-molecule MLK3 inhibitor URMC099 would be reversing murine C57BL/6J were fed either diet high...
Abstract Background Consolation is a type of empathy-like behavior that has recently been observed in some socially living rodents. Despite the growing body literature suggesting stress affects empathy, relationship between and consolation remains understudied at preclinical level. Here, we examined effects chronic emotional or physical exposure on behaviors by using monogamous mandarin vole (Microtus mandarinus) both males females. Method/Results Physical voles were exposed to 14-day social...
The gastrointestinal mucosa is the primary site where human immunodeficiency virus type 1 (HIV-1) invades, amplifies, and becomes persistently established, cell-to-cell transmission of HIV-1 plays a pivotal role in mucosal viral dissemination. Mast cells are widely distributed tract early targets for invasive pathogens, they have been shown to increased density genital HIV-infected women. Intestinal mast express numerous pathogen-associated molecular patterns (PAMPs) combat various viral,...