A5018653096- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Pancreatic and Hepatic Oncology Research
- Nitric Oxide and Endothelin Effects
- Inflammatory Bowel Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Clostridium difficile and Clostridium perfringens research
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Digestive system and related health
- Cancer Research and Treatments
- Eosinophilic Disorders and Syndromes
- Gastrointestinal Tumor Research and Treatment
Akita University
2016-2025
Akita University Hospital
2023-2025
Tohoku University Hospital
2012-2023
Iwate Medical University
2020-2023
Hirosaki University
2023
Aomori Prefectural Central Hospital
2023
Sendai Medical Center
2023
National Hospital Organization
2023
Fukushima Medical University
2023
Yamagata University
2023
<h3>Objective</h3> A multicentre cohort follow-up study of a large number patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma was conducted to elucidate the long-term outcome disease after <i>Helicobacter pylori</i> eradication. <h3>Methods</h3> 420 low-grade MALT who had undergone successful <i>H eradication and been followed up for at least 3 years were registered from 21 participating institutes. Responders treatment defined as whose post-treatment biopsies showed...
The long non-coding RNA HOTAIR has been reported to be a poor prognostic biomarker in variety of malignant tumors. However, little is known about the association with gastric cancer. We examined expression 68 cancer samples using quantitative real-time RT-PCR and analyzed its correlation clinical parameters. functional role was by generating human cell lines increased or suppressed expression. anchorage -independent growth assessed soft agar assay. expressing cells were injected into tail...
An international meeting was organised to develop consensus on (1) the landmarks define gastro-oesophageal junction (GOJ), (2) occurrence and pathophysiological significance of cardiac gland, (3) definition junctional zone (GOJZ) (4) causes inflammation, metaplasia neoplasia occurring in GOJZ.
Although it is widely accepted that Helicobacter pylori (H. pylori) infection an important cause of atrophic gastritis, few studies have examined the relationship between H. pylori-induced gastritis and occurrence reflux esophagitis. The present study was aimed to examine infection, esophagitis in Japan.A total 175 patients with were compared sex- age-matched control subjects. Diagnosis made by gastric mucosal biopsy, rapid urease test, serum IgG antibodies. Severity assessed histology...
Abstract Chronic infection with the bacterial Helicobacter pylori is a major cause of gastric and duodenal ulcer disease, mucosal atrophy, cancer. H. pylori–induced expression intestinal epithelial–specific transcription factor caudal-related homeobox 2 (Cdx2) contributes to metaplasia, precursor event Given role for pattern recognition molecule nucleotide-binding oligomerization domain 1 (NOD1) in innate immune response infection, we investigated mechanisms used by NOD1 regulate its...
There is limited information regarding the benefits of Lenvatinib-transcatheter arterial chemoembolization (LEN-TACE) sequential therapy for unresectable hepatocellular carcinoma (u-HCC). We compared efficacy and safety LEN-TACE to LEN monotherapy investigated factors contributing deep response.We enrolled a multicenter cohort 247 patients with u-HCC treated between 2018 2020. Propensity score matching identified 63 pairs well-balanced characteristics. retrospectively clinical outcomes,...
It remains controversial whether or not Helicobacter pylori infection causes altered gastric acid secretion. A novel test for evaluating secretion (endoscopic gastrin test; EGT) has recently been developed.To investigate by EGT the effects of H eradication on state in patients with peptic ulcer.Twenty six duodenal ulcer and 33 ulcer, all whom had documented, were studied EGT, histological examination mucosa, measurement plasma levels before one seven months after eradication.In mean value...
Summary Background : The acid suppressive effect of lansoprazole is influenced by the P450 2C19 (CYP2C19) polymorphism. Aim To investigate whether CYP2C19 genotype related to healing erosive reflux oesophagitis during treatment with lansoprazole. Methods Eighty‐eight Japanese patients were treated a daily oral dose 30 mg for 8 weeks. genotype, Helicobacter pylori infection status and serum pepsinogen I/II ratio assessed before treatment. At 4 weeks, was evaluated endoscopically. Results...
AIM:To study the value of serum biomarker tests to differentiate between patients with healthy or diseased stomach mucosa: i.e. those Helicobacter pylori (H pylori) gastritis atrophic gastritis, who have a high risk gastric cancer peptic ulcer diseases.
<h3>Objective</h3> There is a strong male predominance of oesophageal adenocarcinoma, which might be related to the higher prevalence precursor lesions such as erosive reflux oesophagitis in men compared with women. This experiment investigated gender difference model rats and explored potential role oestrogen controlling tissue damage. <h3>Design</h3> An acid-reflux was surgically produced female rats, ascorbic acid diet sodium nitrite drinking water were administered half either group...
Acetaldehyde (ACH) associated with alcoholic beverages is Group 1 carcinogen to humans (IARC/WHO). Aldehyde dehydrogenase (ALDH2), a major ACH eliminating enzyme, genetically deficient in 30–50% of Eastern Asians. In alcohol drinkers, ALDH2-deficiency well-known risk factor for upper aerodigestive tract cancers, i.e., head and neck cancer esophageal cancer. However, there only limited evidence stomach this study we demonstrated the first time that ALDH2 deficiency results markedly increased...
Few studies have simultaneously evaluated the long-term outcomes of endoscopic resection (ER) for squamous cell carcinoma (SCC) and adenocarcinoma (AC) esophagus in Japan. The objective this study was to evaluate ER superficial esophageal cancer consecutive patients.This a retrospective from single institution. From April 2001 June 2012, 204 patients with SCC 26 AC were included total 355 who treated by at Tohoku University Hospital. Patients submucosal invasion deeper than 200 μm...
<b>Background:</b> Saliva has a high nitrite concentration, derived from the enterosalivary recirculation of dietary nitrate, and is main source entering acidic stomach. Acidification in presence secondary amines or amides generates potentially carcinogenic <i>N</i>-nitroso compounds. The reaction inhibited by ascorbic acid catalysed thiocyanate. <b>Aim:</b> To determine whether there intragastric regional variation chemical conditions promoting luminal nitrosation following nitrate...
Background: The role of acid secretion in reflux oesophagitis which may develop after H. pylori eradication is not well known. Aim: To investigate the participation altered gastric and presence hiatal hernia development therapy for . Subjects Methods: A total 105 patients with infection, but without at time therapy, were followed prospectively 7 months clearance this microorganism. Gastric was assessed by endoscopic gastrin test, endoscopy. Results: Reflux developed 11 out (10.5%) when...
High luminal concentrations of nitric oxide are generated at the human gastro-oesophaegal junction and within Barrett's oesophagus due to reduction salivary nitrite by acidic gastric juice. Salivary is derived from entero-salivary recirculation dietary nitrate. Our aim was determine whether lumen will exert nitrosative stress on adjacent epithelium. A benchtop model constructed reproducing chemistry occurring upper gastrointestinal tract where saliva encounters It incorporated an epithelial...
The acidity of the refluxate into esophagus is a key factor for pathogenesis gastroesophageal reflux disease. Helicobacter pylori (H. pylori) infection can influence gastric acid secretion. We have reported that H. prevents esophagitis by decreasing secretion in Japanese patients, but role this organism Barrett's unclear. aim study was to investigate prevalence and patients with or without esophagus.We enrolled 112 who were examined status study. They divided three groups, according presence...
We have previously developed a rapid, simple endoscopic method for evaluating gastrin-stimulated maximal acid output (the gastrin test, EGT). In EGT, gastric fluid newly secreted over 10 min after stimulation is collected under direct visualization. this study, employing the we evaluated effect of rebamipide, cytoprotective anti-ulcer drug, on mucus secretion. ten Helicobacter pylori-negative healthy volunteers, juice was by EGT prior to and 4-week administration rebamipide. The subjected...
Atrophic gastritis (AG) is a well-recognized high-risk condition for developing gastric cancer (GC). Gastrin 17 (G17), hormone secreted from antral G cells, regulates acid secretion, and its serum level possible indicator of atrophy. Serum pepsinogen well established as the AG involving corpus. Here we investigated whether PG G17 levels would be useful determining topographic pattern estimating risk GC. Enrolled were 122 Japanese patients with early GC (114 well- to moderate-differentiated...