A5023367894- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Pancreatic function and diabetes
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Pediatric Hepatobiliary Diseases and Treatments
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- IgG4-Related and Inflammatory Diseases
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Circular RNAs in diseases
- HER2/EGFR in Cancer Research
- Cancer Research and Treatments
- RNA Research and Splicing
- TGF-β signaling in diseases
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Galectins and Cancer Biology
Tohoku Medical and Pharmaceutical University Hospital
2019-2025
Tohoku Medical and Pharmaceutical University
2019-2023
Miyagi Prefectural Hospital Organization
2012-2021
Tochigi Cancer Center
2012-2020
Komatsu (Japan)
2019
Tohoku University
2006-2017
Stanford University
2013
National Institute of Advanced Industrial Science and Technology
2011
Tokyo Women's Medical University
2011
University Gastroenterology
2006
The long non-coding RNA HOTAIR has been reported to be a poor prognostic biomarker in variety of malignant tumors. However, little is known about the association with gastric cancer. We examined expression 68 cancer samples using quantitative real-time RT-PCR and analyzed its correlation clinical parameters. functional role was by generating human cell lines increased or suppressed expression. anchorage -independent growth assessed soft agar assay. expressing cells were injected into tail...
The feasibility of neoadjuvant chemoradiation therapy for cholangiocarcinoma, followed by conventional resection, has not been determined yet. Here, a phase I study therapy, named NACRAC, was performed to determine the maximum tolerated dose (MTD) and recommended (RD) gemcitabine when combined with external beam radiation resectable cholangiocarcinoma.From August 2007 June 2008, 12 patients provided informed consent. Preoperative administered in 1.8Gy daily fractions up total 45Gy....
BACKGROUND Survivin is a new member of the inhibitor apoptosis family antiapoptotic proteins. This protein was expressed selectively in all most common human carcinomas but not normal adult tissues. To our knowledge, relation between survivin expression and or tumorigenesis has yet been studied pancreatic neoplasms. METHODS The authors investigated 4 carcinoma cell lines 56 tissues (5 cases normal, 12 chronic pancreatitis [CP], 26 duct adenocarcinoma [PDC], 16 lesions 13 intraductal...
Pancreatic cancer is characterized by excessive desmoplastic reaction and a hypoxic microenvironment within the solid tumor mass. Chronic pancreatitis also fibrosis hypoxia. Fibroblasts in area of these pathological settings are now recognized as activated pancreatic stellate cells (PSCs). Recent studies have suggested that environment concomitantly exists not only but surrounding PSCs. This study aimed to clarify whether hypoxia affected cell functions Human PSCs were isolated cultured...
We have encountered cases of unusual intraductal pancreatic neoplasms with predominant tubulopapillary growth. collected data on 10 similar “intraductal (ITPNs)” and analyzed their clinicopathologic molecular features. Tumor specimens were obtained from 5 men women a mean age 58 years. ITPNs solid nodular tumors obstructing dilated ducts did not contain any visible mucin. The tumor cells formed tubulopapillae contained little cytoplasmic exhibited uniform high-grade atypia. Necrotic foci...
p62/SQSTM1 is a selective substrate of autophagy, and aberrant accumulation p62 has been observed in various pathological conditions. To understand the roles plays non-small-cell lung cancer (NSCLC), we carried out immunohistochemical analyses expression cohort patients with annotated clinicopathological data. As murine human hepatocellular carcinomas suggested correlation between Nrf2 accumulations, also examined NRF2 same cohort. The was by methods 109 NSCLC cases, which included...
Several recent studies have revealed that microRNAs (miRNAs) a role in carcinogenesis and cancer development, it is stably detectable plasma/serum. The aim of this study was to test whether miR‑483-3p as well miR‑21 could be plasma biomarkers for PDAC. samples were obtained from three groups including 32 pancreatic ductal adenocarcinoma (PDAC) patients, 12 patients with intraductal papillary mucinous neoplasm (IPMN) 30 healthy controls (HC). We evaluated the expression level by quantitative...
Abstract The epithelial-mesenchymal transition (EMT) is a critical step for pancreatic cancer cells as an entry of metastatic disease. Wide variety cytokines and signaling pathways are involved in this complex process while the entire picture still cryptic. Recently, miRNA was found to regulate cellular function including EMT by targeting multiple mRNAs. We conducted comprehensive analysis expression profiles invasive ductal adenocarcinoma (IDA), intraductal papillary mucinous adenoma,...
Objectives: A nationwide epidemiological survey was conducted to estimate the number of patients treated for acute pancreatitis (AP) in 2007 Japan and clarify clinicoepidemiological features AP. Methods: In first survey, a simple questionnaire used inquire about with AP who visited hospital year 2007. This directly mailed heads 3027 facilities. The second forwarded those facilities from which were reported on questionnaire. Results: estimated total 57,560 (95% confidence interval,...
Abstract Periostin is a secretory protein that has been suggested to function as cell adhesion molecule and promote the invasiveness or growth rate of tumors. However, little known about association its expression epithelial mesenchymal transition (EMT), which considered play crucial role in cancer metastasis. Thus, authors investigated whether periostin could be involved process EMT this gene pancreatic development. The was observed mainly stromal cells but very by immunohistochemistry...
Activated pancreatic stellate cells (PSCs) play an important role in fibrosis and inflammation, where oxidative stress is implicated the pathogenesis. NADPH oxidase might be a source of reactive oxygen species (ROS) injured pancreas. This study aimed to clarify expression regulation cell functions by PSCs. PSCs were isolated from rat human pancreas tissues. Expression was assessed reverse transcription-PCR immunostaining. Intracellular ROS production using 2′,7′-dichlorofluorescin diacetate....
<h3>Objective:</h3> Fibroblasts in the area of fibrosis chronic pancreatitis and desmoplastic reaction associated with pancreatic cancer are now recognised as activated stellate cells (PSCs). Recent studies have shown strong expression fibrinogen, central protein haemostasis pathway, stromal tissues pancreatitis, suggesting that PSCs embedded exposed to abundant fibrinogen these pathological settings. The effects on cell functions were examined here. <h3>Methods:</h3> isolated from human...
Invasive ductal adenocarcinoma (IDA) of the pancreas manifests poor prognosis due to early invasion and distant metastasis. In contrast, intraductal papillary mucinous adenoma or carcinoma (IPMA IPMC) reveals better clinical outcomes. Various molecular mechanisms contribute these differences but entire picture is still unclear. Recent researches emphasized important role miRNA in biological processes including cancer We previously described that miR-126 down-regulated IDA compared with IPMA...
Intraductal tubulopapillary neoplasm (ITPN) is a recently recognized rare variant of intraductal neoplasms the pancreas. Molecular aberrations underlying remain unknown. We investigated somatic mutations in PIK3CA, PTEN, AKT1, KRAS, and BRAF. also aberrant expressions phosphorylated AKT, phosphatase tensin homolog (PTEN), tumor protein 53 (TP53), SMAD4, CTNNB1 11 cases ITPNs compared these data with those 50 papillary mucinous (IPMN), another distinct pancreatic neoplasms. Mutations PIK3CA...
Abstract Endosomal sorting required for transport (ESCRT) complexes orchestrate endo-lysosomal of ubiquitinated proteins, multivesicular body formation and autophagic degradation. Defects in the ESCRT pathway have been implicated many neurodegenerative diseases, but underlying molecular mechanisms that link them to neurodegeneration remain unknown. In this study, we showed forebrain-specific ablation ESCRT-0/Hrs induced marked hippocampal neuronal cell loss accompanied by accumulation...
Abstract Some patients with ulcerative colitis (UC) suffer from complicated UC-associated upper gastrointestinal lesions. However, the trigger of these lesions has not been clarified. Herein, we present a 28-year-old man relapsed pan-colonic UC accompanied by gastroduodenal immediately after contracting coronavirus disease 2019 (COVID-19). In this patient, approximately 7 days COVID-19 onset, despite being in remission for 3 years. The patient also developed symptoms such as epigastric pain...
Intraductal mucin-hypersecreting neoplasm of the pancreas (IMHN) is a unique tumor that composed cells with different cell atypia. K-ras and p53 alterations have been shown to occur in pancreatic duct carcinoma (PDC), but they not well documented individual lesion IMHN. The aim this study was examine relation genetic IMHN tumorigenesis pancreas. In 32 microscopically dissected lesions seven cases IMHN, mutation investigated by primer-mediated, mutant-enriched, polymerase chain...
Abstract Activated pancreatic stellate cells (PSCs) play a pivotal role in the pathogenesis of fibrosis and inflammation. Inhibition activation cell functions PSCs is potential target for treatment The polyphenol compound curcumin yellow pigment curry, has anti‐inflammatory anti‐fibrotic properties. We here evaluated effects on PSCs. were isolated from rat pancreas tissue used their culture‐activated, myofibroblast‐like phenotype unless otherwise stated. proliferation, α‐smooth muscle actin...