A5015247832- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cell Adhesion Molecules Research
- Pediatric Hepatobiliary Diseases and Treatments
- Renal Diseases and Glomerulopathies
- Cancer Genomics and Diagnostics
Dokkyo Medical University
2018-2024
Social Insurance Saitama Chuo Hospital
2018-2024
Dokkyo Medical University Saitama Medical Center
2015-2024
Mitsui (Japan)
2020
Saiseikai Fukuoka General Hospital
2010-2016
Aichi Cancer Center
2011
Saitama Medical University
2001-2010
Tohoku University Hospital
2009
Saitama International Medical Center
2008-2009
Hokkaido University
2007-2008
<h3>Objective</h3> The clinicopathological significance of four morphological types intraductal papillary mucinous neoplasms the pancreas (IPMNs; gastric, intestinal, pancreatobiliary and oncocytic) was assessed. <h3>Design</h3> Retrospective multicentre analysis 283 surgically resected IPMNs. <h3>Results</h3> Of IPMNs, 139 were gastric type, 101 19 24 oncocytic. These significantly associated with factors including sex (p=0.0032), age (p=0.00924), ectatic duct size (p=0.0245), detection...
Pancreatic ductal adenocarcinoma (PDAC) may derive from an intraductal papillary mucinous neoplasm (IPMN) of the pancreas or develop in pancreatic duct apart IPMN. The purpose this study was to define clinicopathological features these 2 entities and compare them with those ordinary PDAC.Of 765 patients who had surgical resection for IPMN, 122 were diagnosed as having PDAC derived IPMN 31 concomitant In addition, 7605 registered Japan Pancreas Society cancer registry compared above...
We have encountered cases of unusual intraductal pancreatic neoplasms with predominant tubulopapillary growth. collected data on 10 similar “intraductal (ITPNs)” and analyzed their clinicopathologic molecular features. Tumor specimens were obtained from 5 men women a mean age 58 years. ITPNs solid nodular tumors obstructing dilated ducts did not contain any visible mucin. The tumor cells formed tubulopapillae contained little cytoplasmic exhibited uniform high-grade atypia. Necrotic foci...
Intraductal papillary mucinous neoplasm (IPMN) is a unique pancreatic developing in the ductal system. Two major histologic subtypes have been reported, that gastric type and intestinal type. However, their histopathologic features, especially those of type, not fully described. To evaluate features these two types refine differences, we analyzed 80 IPMNs including 50 cases 30 with mucin immunohistochemistry. By defining main duct-type lesion as predominantly involving duct or without branch...
Endoscopic mucosal resection (EMR), which is advocated for the treatment of early (superficial) gastroesophageal neoplasms, has also been alluded to represent a superior diagnostic and staging modality. We compared concordance preceding biopsies with EMR specimens in 31 gastric 10 esophageal EMRs consisting 6 low-grade 12 high-grade dysplasias, 21 intramucosal adenocarcinomas, 2 submucosal invasive adenocarcinomas. Discrepancies were considered as either major or minor if histologic grades...
Intraductal tubulopapillary neoplasm (ITPN) is a recently recognized rare variant of intraductal neoplasms the pancreas. Molecular aberrations underlying remain unknown. We investigated somatic mutations in PIK3CA, PTEN, AKT1, KRAS, and BRAF. also aberrant expressions phosphorylated AKT, phosphatase tensin homolog (PTEN), tumor protein 53 (TP53), SMAD4, CTNNB1 11 cases ITPNs compared these data with those 50 papillary mucinous (IPMN), another distinct pancreatic neoplasms. Mutations PIK3CA...
The restoration of squamous epithelium after photodynamic therapy (PDT) for Barrett esophagus (BE) and its related neoplasms has been noted. It may result in the development buried and/or BE underneath restored which maintain their potential malignant transformation. purpose this study was to evaluate prevalence, endoscopic, histologic characteristics also response further treatment neoplastic developing PDT. Fifty-two patients with high-grade dysplasia (n=19), intramucosal adenocarcinoma...
Abstract Background Stricture formation is one of the major complications after endoscopic removal large superficial squamous cell neoplasms esophagus, and local steroid injections have been adopted to prevent it. However, fundamental pathological alterations related them not well analyzed so far. The aim this study was analyze time course healing process esophageal mucosal defects resulting in stricture its modification by injection, using an animal model. Methods Esophageal circumferential...
Very well-differentiated gastric adenocarcinoma of intestinal type is a rare variant cancer characterized by low-grade nuclear atypia, and for which the diagnostic criteria clinical behavior are not fully established. This study presents detailed histologic, immunohistochemical, analysis 21 cases. Nuclear atypia was mild in all Characteristic architectural features this were pit glandular anastomosis, spiky glands, distended discohesive cells, abortive outgrowth. At least three these present...
The efficacy of photodynamic therapy (PDT) is currently evaluated for the treatment superficial neoplasms arising in Barrett's esophagus (BE). An accurate assessment this technique requires evaluation biopsies before and after treatment. However, despite importance pathology, only a limited number studies have systematically assessed mucosal changes PDT. To evaluate PDT, pathologic variables that may impact on success therapy, we analyzed pre- post-PDT cohort patients treated by modality....
Maternal smoking during pregnancy can result in both complications and reduced size of the fetus neonate. Among women who smoke, genetic susceptibility to tobacco smoke also is a likely causative factor adverse outcomes. A prospective cohort study was conducted among 460 pregnant delivered live singletons Sapporo, Japan, from 2002 2005. Multiple linear regression models were used estimate associations maternal polymorphisms two genes encoding N-nitrosamine-metabolizing enzymes—NAD(P)H:...
The etiology of hypospadias is regarded as a complex disorder with both genetic and environmental contributions. Although alterations in androgen activity have been associated hypospadias, few associations estrogen documented. Here, we assessed polymorphisms receptor genes their association hypospadias.Using case-control study 59 cases 286 controls, examined the following polymorphisms: PvuII XbaI ESR1, 2681-4A>G ESR2.For cases, found negative G allele containing variants ESR1 (OR = 0.52, P...
In this study, we have shown that intravenously administered antisense oligodeoxynucleotide (ODN) was demonstrated to be taken up by tubular epithelium, after which it blocked mRNA expression of target genes in normal and nephritic rats. Therefore, injected osteopontin (OPN) ODN Goodpasture syndrome (GPS) rats every second day between days 27 35, the time when renal OPN increased interstitial monocyte infiltration aggravated. parallel blockade expression, treatment significantly attenuated...
Background and Aim: Presently, the differential diagnosis of gastric adenoma well-differentiated adenocarcinoma by endoscopy is very difficult. We carried out magnifying with narrow band imaging (NBI) in lesions that required discrimination between adenocarcinoma, prospectively evaluated whether tumor typing we propose useful for their diagnosis. Methods: The materials were 93 among epithelial tumors which endoscopic treatment was planned at three facilities during 14 months November 2008...
Abstract Background and Aim The cytokeratin ( CK )7 − / 20 + immunoprofile is characteristic of colorectal carcinoma CRC ), although 7 or phenotypes are occasionally encountered, particularly in histologically variant s. We analyzed 7/ profiles s association with clinicopathologic parameters prognosis. Methods expression well‐ moderately differentiated adenocarcinoma WMDA ) n = 63), poorly PDA 91), mucinous MUA 81), signet‐ring cell SRCC 15), undifferentiated UDC 12), adenosquamous 2) was...
We reviewed the clinicopathological findings of eight cases sessile serrated adenoma/polyps ( SSA / P s) with carcinoma, largest diameter which was 10 mm or less. All lesions were polyps located in right side colon. Four showed submucosal invasion and one lesion invaded proper muscle layer. The depth invasion, however, did not seem to be related carcinoma area size. Most carcinomas well moderately differentiated tubular adenocarcinomas focally showing some appearances, predominant component...
APC and transforming growth factor‐β type II receptor (TGF‐β RII) gene mutations, microsatcllitc instability have been found in sporadic colorectal carcinomas. To clarify further the early alterations carcinogenesis, we investigated these genetic changes 23 protruding‐ 24 superficial‐type mucosal TGF‐β RII mutations microsatellite were rarely lesions. Nevertheless, was mutated 16 of 47 (34.0%) carcinomas significantly more frequently (I) superficial elevated‐type (Ila) (14/32,43.8%) than...