A5089776213- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Heart Failure Treatment and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Parathyroid Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
- Peripheral Artery Disease Management
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Chemotherapy-induced cardiotoxicity and mitigation
- Atherosclerosis and Cardiovascular Diseases
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Cardiac Arrhythmias and Treatments
- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Potassium and Related Disorders
- Acute Ischemic Stroke Management
- Climate Change and Health Impacts
Kumamoto University
2015-2024
Kumamoto University Hospital
2017-2023
Weatherford College
2019-2021
Miyazaki Prefectural Hospital
2021
Suzuki (Japan)
2019
Yokohama City University
2013
Yamaguchi University Hospital
2013
Yokohama City University Medical Center
2013
Background: Dipeptidyl peptidase 4 (DPP4) inhibitors are used for treatment of diabetes mellitus (DM). We hypothesized that sitagliptin, a DPP4-inhibitor, could improve endothelial dysfunction in DM patients with coronary artery disease (CAD). Methods and Results: The 40 CAD uncontrolled DM, aged 68.7±9.4 years (mean±standard deviation) (50% males, hemoglobin A1c [HbA1c] 7.4±1.0%) were assigned to either additional sitagliptin (50mg/day, n=20) or aggressive conventional (control, 6 months....
Background Endothelial dysfunction is a key component of vascular vulnerability. Reactive hyperemia index ( RHI ), as assessed by the peripheral arterial tonometry, can noninvasively evaluate endothelial function. This study was designed to determine additional prognostic value function Synergy Between PCI With Taxus and Cardiac Surgery Score SYNTAX sc) Framingham Risk FRS ) in predicting cardiovascular events high‐risk patients. Methods Results We undertook two‐center prospective 528 stable...
Several studies have reported that colchicine attenuated the infarct size and inflammation in acute myocardial infarction (MI). However, sustained benefit of administration on survival cardiac function after MI is unknown. It was hypothesized short-term treatment with could improve during recovery phase MI.Methods Results:MI induced mice by permanent ligation left anterior descending coronary artery. Mice were then orally administered 0.1 mg/kg/day or vehicle from 1 h to day 7 MI. Colchicine...
LCZ696 (sacubitril/valsartan) can lower the risk of cardiovascular events in chronic heart failure. However, it is unclear whether improve prognosis patients with acute myocardial infarction (MI). The present study shows that prevent cardiac rupture after MI, probably due to suppression pro-inflammatory cytokines, matrix metalloproteinase-9 activity and aldosterone production, enhancement natriuretic peptides mice. These findings suggest mechanistic insight cardioprotective effects against...
Abstract Background The H2FPEF score is recognized as a simple method to diagnose heart failure (HF) with preserved left ventricular ejection fraction (HFpEF). We investigated the value of in predicting subsequent cardiovascular events HFpEF patients. Methods This study was retrospective, single-center, observational study. calculated scores for 404 consecutive Subjects were subdivided into low- (0–3), intermediate- (4–6), and high-score (7–9) groups followed 50 months. primary secondary...
With the advancement in successfully treating different types of cancers, there is an immediate and increased need to focus on risk complexity cardiovascular events cancer survivors. This has led emergence onco-cardiology/cardio-oncology field. We examined varying incidence after percutaneous coronary intervention (PCI) patients with or without cancer.Participants were divided into a non-malignant group malignant group, consisting who receiving had ever received treatment. The primary...
Current guidelines recommend several direct oral anticoagulant agents (DOACs) equally for managing cancer-associated venous thromboembolism (VTE). The aim of this study was to assess the efficacy and safety DOACs in patients with active cancer. Literature searches were conducted PubMed, Embase, Cochrane Central November 2022. Randomized controlled trials investigating anticoagulation strategies (vitamin K antagonists, parenteral [eg, low-molecular weight heparin], DOACs) VTE cancer...
Abstract Aims Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is often accompanied by atrial fibrillation (AF), flutter (AFL), and tachycardia (AT), which are difficult to control because beta-blockers antiarrhythmic drugs can worsen heart failure (HF). This study aimed investigate the outcomes of catheter ablation (CA) for AF/AFL/AT in patients with ATTRwt-CM propose a treatment strategy CA. Methods results A cohort was conducted on 233 diagnosed ATTRwt-CM, including 54 who...
Background:Endothelial dysfunction plays a crucial role in heart failure (HF), but the association between peripheral microvascular endothelial function assessed by reactive hyperemia arterial tonometry (RH-PAT) and prognosis remains unknown HF with reduced left ventricular (LV) ejection fraction (HFREF). We prospectively investigated HF-related near-future cardiovascular outcomes HFREF patients.Methods Results:The 362 patients (LVEF <50%) were followed for events (composite of death...
Abstract Aims The focus on wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is increasing because of novel treatment options. There currently no report a large number Japanese patients with ATTRwt‐CM. study aimed to examine the characteristics and prognosis ATTRwt‐CM in Japan. Methods results Consecutive (78.5 ± 6.4 years old at diagnosis) diagnosed Kumamoto University Hospital between December 2002 2019 were retrospectively reviewed. Data, including demographic characteristics,...
BACKGROUND. A super-resolution deep learning reconstruction (SR-DLR) algorithm may provide better image sharpness than earlier algorithms and thereby improve coronary stent assessment on CTA. OBJECTIVE. The purpose of our study was to compare SR-DLR other in terms quality measures related evaluation patients undergoing METHODS. This retrospective included with at least one artery who underwent CTA between January 2020 December 2020. Examinations were performed using a 320-row...
from collapsing homes.The incidence of cardiovascular disease (hypertension, 3 acute myocardial infarction, 4 heart failure, pulmonary thromboembolism [PTE] 5,6 and deep vein thrombosis [DVT], 5 other diseases 3,7-9 ), stroke, respiratory infections 10 increases in evacuees after disasters.These concepts have been comprehensively reviewed. 11The unsanitary environment evacuation centers, sympathetic K umamoto Prefecture Japan was struck by a series earthquakes (2016 Kumamoto 1,2 including...
Background: Simple office-based counseling for diet and exercise does not appear to positively affect success rates in metabolic syndrome (MetS) patients. The utility of the lifestyle modification self-assessment score (Self-AS) improvement endothelial function by patients with MetS was investigated. Methods Results: Patients (n=207) age- sex-matched individuals without (n=124) were enrolled this cross-sectional study. Endothelial assessed using reactive hyperemia-peripheral arterial...
Reactive oxygen species (ROS) are associated with development of coronary artery disease (CAD). However, there's no useful biomarker ROS in CAD.We recruited 395 consecutive CAD patients who were performed angiography (262 male and 133 female, age 70.2±10), we measured serum derivatives reactive oxidative metabolites (DROM) measured. Two hundred twenty-seven non-CAD also enrolled. We follow-up study these case-control after risk factor 1:1 pair matching (both, n=163). As subgroup analysis,...
Objective: Recent studies have shown that inter-arm blood pressure differences (IAD) may be a risk factor for cardiovascular events; however, none addressed them in patients with coronary artery disease (CAD). Methods: We measured bilaterally the ankle brachial index (ABI) 657 suspected CAD and assessed presence of by angiography, severity atherosclerosis Gensini score. Results: Mean IADs were significantly greater matched than those without it (P = 0.01), whereas scores high IAD (≥10 mmHg)...
Abstract Although there is accumulating evidence for the usefulness of imaging-guided percutaneous coronary intervention (PCI), are few studies acute syndrome (ACS), and impact frequency use has not been well addressed. From Kumamoto Intervention Conference Study; a Japanese registry comprising 17 institutions, consecutive patients undergoing successful PCI from April 2008 through March 2014 were enrolled. Subjects divided into two groups: angiography-guided PCI. Clinical outcome was...
The prediction of future heart failure (HF) in stable outpatients is often difficult for general practitioners and cardiologists. Recently, the H2 FPEF score (0-9 points) has been proposed discrimination HF with preserved ejection fraction from non-cardiac causes dyspnoea. six clinical echocardiographic variables that constitute include following: (i) obesity (H); (ii) use ≥2 antihypertensive drugs (iii) atrial fibrillation (F); (iv) pulmonary hypertension (P); (v) an age > 60 years (E);...
Pentraxin 3 (PTX3) is a novel inflammatory marker produced by various cell types including those of the vasculature and heart. The relationship between markers prognosis patients with heart failure normal ejection fraction (HFNEF) remains unknown. We investigated whether plasma PTX3 levels can predict future cardiovascular events in HFNEF.Plasma PTX3, high-sensitivity C-reactive protein, B-type natriuretic peptide were measured prospectively 360 stable HFNEF. subsequent incidence events,...