A5101803893- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Cholesterol and Lipid Metabolism
- Cardiovascular Function and Risk Factors
- Drug Transport and Resistance Mechanisms
- Adipose Tissue and Metabolism
- S100 Proteins and Annexins
- Protease and Inhibitor Mechanisms
- Cancer, Lipids, and Metabolism
- Urticaria and Related Conditions
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Liver Diseases and Immunity
- Autoimmune Bullous Skin Diseases
- Hormonal Regulation and Hypertension
- Macrophage Migration Inhibitory Factor
- Peptidase Inhibition and Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Phenothiazines and Benzothiazines Synthesis and Activities
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Cardiomyopathy and Myosin Studies
- Clusterin in disease pathology
Kumamoto University
2016-2024
Kyushu University
2024
Matsumoto University
2023
Saiseikai Kumamoto Hospital
2022
Kumamoto Medical Center
2020
Jichi Medical University
2003-2015
Shizuoka Institute of Science and Technology
2014
Kagawa University
2008
Osaka International Cancer Institute
2006
Shizuoka General Hospital
2000-2004
Sirt (Sirtuin) 7, the most recently identified mammalian sirtuin, has been shown to contribute appropriate wound healing processes after acute cardiovascular insult. However, its role in development of cardiac remodeling pressure overload is unclear. Cardiomyocyte-specific Sirt7-knockout and control mice were subjected induced by transverse aortic constriction. Cardiac hypertrophy functions then examined these mice. Sirt7 protein expression was increased myocardial tissue overload....
S100 protein A8 and A9 naturally form a stable heterocomplex. Recently, we have proved that S100A9 overexpression in various adenocarcinomas is associated with poor tumor differentiation. In this study, examined the relationship between expression of each pathological parameters reflect aggressiveness carcinoma, invasive ductal carcinoma (IDC) breast. Serial paraffin-embedded tissue sections from 101 IDC cases were immunostained respective monoclonal antibodies, results as follows: 1) A...
Abstract Aims The focus on wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is increasing because of novel treatment options. There currently no report a large number Japanese patients with ATTRwt‐CM. study aimed to examine the characteristics and prognosis ATTRwt‐CM in Japan. Methods results Consecutive (78.5 ± 6.4 years old at diagnosis) diagnosed Kumamoto University Hospital between December 2002 2019 were retrospectively reviewed. Data, including demographic characteristics,...
We characterized a microbial strain that was isolated from hot spring at geothermal area in Hakone, Japan. This isolate, whose lobed-shaped cells were about 1.0 μ diameter, facultative chemolithoautotroph required aerobic conditions for growth. The optimum pH 3.0 (pH range, to 4.0), and the temperature 70°C (temperature 50 80°C). Lithotrophically, this grew on elemental sulfur reduced compounds. G+C content of genomic DNA 38.4 mol%. organism contained calditoglycerocaldarchaeol, which is...
Influenza virus is rich in variation and mutations. It would be very convenient for detection isolation to histochemically detect viral infection regardless of Here, we established a histochemical imaging assay influenza sialidase activity living cells by using new fluorescent substrate, 2-(benzothiazol-2-yl)-4-bromophenyl 5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosidonic acid (BTP3-Neu5Ac). The BTP3-Neu5Ac visualized virus-infected hosts subtypes. neuraminidase-expressed...
Background Cardiac fibrosis plays a crucial role in the pathogenesis of dilated cardiomyopathy (DCM). HE4 (human epididymis protein 4) is secretory expressed activated fibroblasts that exacerbates tissue fibrosis. In present study, we investigated clinical utility measurement patients with DCM and its pathophysiological preclinical experiments vivo vitro. Methods Results We measured serum levels 87 DCM. Endomyocardial biopsy severe only high group ( P <0.0001). Echocardiography showed...
Abstract Aims This study was performed to investigate whether left atrial (LA) strain by echocardiography provides prognostic information in patients with wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM). Methods and results Among 129 who were diagnosed ATTRwt‐CM at Kumamoto University Hospital from December 2002 2019, 113 had enough for two‐dimensional speckle tracking enrolled this study. During a median follow‐up of 668 days, 28 cardiovascular deaths occurred. Compared the...
It has been reported that a staging system combining N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T (hs-cTnT) or estimated glomerular filtration rate (eGFR) is useful in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). However, these studies were mainly conducted Western countries, their usefulness for the Japanese population unclear. We examined validated using hs-cTnT, eGFR, B-type (BNP) ATTRwt-CM.We retrospectively evaluated 176...
Krill, which morphologically resembles small shrimp, represents ocean crustaceans and has been used for human consumption in Japan some other countries. The major allergen reported to be tropomyosin, but the allergenicity of krill tropomyosin remains uncertain.Amino acid sequences two species (Euphausia superba E. pacifica) were deduced. Recombinant tropomyosins produced Escherichia coli using a pCold IV vector system, cross-reactivity shrimp allergy-related IgE recombinant several animal...
β-Blocker (BB) use is a mainstay for the treatment of heart failure (HF) with reduced ejection fraction (HFrEF), whereas its efficacy preserved (HFpEF) remains controversial. Women outnumber men in HFpEF, women HFrEF. Plasma B-type natriuretic peptide (BNP) established as biomarker HF. We examined whether BB associated plasma BNP levels differently and HFpEF. The study subjects comprised 721 patients HFpEF [left ventricular (LVEF) ≥ 50%] (184 men, mean age 78.2 ± 9.2 yr 537 women, 83.1 8.8...
In an effort to develop new types of antiulcer agents, a series novel 3(2H)-pyridazinone derivatives and related analogues was synthesized. Substituted 3(2H)-pyridazinones their 4,5-dihydro were alkylated by omega-haloalkyl cyanides at the N-2 position under phase-transfer catalytic reaction, nitrile group converted thio amide treatment with hydrogen sulfide alone or appropriate primary secondary amines. Various substituents introduced on nitrogen amide, carbon in side chains, ring. The...
Coronary plaques in patients with coronary vasospastic angina have been characterized by diffuse intima-media thickening homogeneous fibrous tissue, without confluent necrotic tissue. However, vasospasm can trigger thrombosis, and may play an important role the pathogenesis of acute syndromes, though precise morphological mechanisms underlying this process remain unclear.A 43-year-old man a history multivessel had treated long-acting diltiazem fluvastatin since 2004. Eleven years later,...
An aqueous two-phase partitioning study of partially purified nuclear thyroid hormone receptor from rat liver was performed. Stability 3,5,3'-tri-iodo-L-thyronine (T3)-receptor complex and T3-binding activity in the presence dextran or polyethylene glycol were assessed order to determine amount occupied unoccupied receptors each phase. Partition coefficients calculated as ratio concentration upper glycol-rich phase H2O that lower dextran-rich H2O. The partition coefficient a sensitive...